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🚨 No slogans. No ideology. Only structure. Dr. Sandeep Pathak exposes the 2047 dream with hard data. ₹20k today. ₹60–70k in 20 years. Developed nations: ₹3–4 lakh. Discretion over rules. Weak institutions. 0.6% R&D. Budgets don’t build nations. Systems do. 🎯

Mr Sharma

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🚨 RUBIO DROPS THE HAMMER ON NGOS – “NO MORE OPEN-ENDED TAXPAYER CASH” Marco Rubio is absolutely right—taxpayer money should help nations build their own institutions, not empower unaccountable NGOs that undermine them. For years, Western NGOs have operated as shadow governments, bypassing elected leaders and steering policy in countries they do not answer to. That era must end. True partnership means working with sovereign governments, strengthening local systems, and respecting national decision-making — not creating parallel structures that profit from dependency. This is long overdue. A genuinely historic correction.

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Data labelling is a fricking hard market and there are some core questions. 1. Why does no player want to be called a talent marketplace? 2. Is the proclaimed “revenue” real revenue or GMV? 3. What are the margins given the GMV structure of the business? 4. Are the players not concerned by the concentration of revenue with 2 customers being over 50% of revenue for every player in market? 5.If synthetic data continues to improve, WTF happens to their core business? We do not pull punches in this discussion with Top 5 takeaways below 👇 Spotify 👉 Youtube 👉 Apple Podcasts 👉 Timestamps: 00:00 Intro 00:51 Redefining “Talent Marketplaces” Today 03:46 Data, Compute, Algorithms: What is Most Abundant? 16:59 The Biggest Challenges Enterprises Have with AI Adoption 20:57 Why Will 99% of Knowledge Work Will be Gone in 10 Years 28:53 How Will Data-Driven Feedback Loops Replace Technology as the Moat 34:20 Is Revenue BS in Data Labelling? Are Players Calling GMV Revenue? 43:43 Are We in an AI Bubble? 52:22 Why is SaaS Dead in a World of AI? 01:00:32 Will the Phone be the Primary User Interface to an AI World? 01:07:46 Quick-Fire Round

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🚨 BREAKING — TRUMP PUTS HIS FOOT DOWN: Slaps 50% tariffs on ALL Canadian cars, trucks, auto parts and STEEL effective Jan. 1 2027 "Canada will be treated like a STATE NO LONGER!" 🔥 FAFO is playing out! "On Trade, and in other ways, also, they are among the worst Nations in the World to deal with. They feel entitled, and yet, WE DON’T NEED CANADA, THEY NEED US!" "They do 95% of their business with the U.S., with us, the exact opposite!" "Canada has been ripping off the United States of America for years. Their ridiculously high tariffs on our Farmers and farm products has made life impossible for these great American Patriots, and has long created a 60 Billion Dollar Deficit between our two Countries. Not sustainable, and NOT ANYMORE! On January First, 2027, Tariffs on all Cars, Trucks, both large and small, Automotive Parts, and Steel, will be increased to 50%. Build in the U.S. and there are ZERO TARIFFS." This is why you never mess with Trump.

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🚨 3I/ATLAS: The Colossus from Interstellar Space Dr. Avi Loeb confirms new data shows this object is at least 33 billion tons, over 100,000 times more massive than Oumuamua. Its minimum size is 5 km across, possibly up to 46 km, bigger than Manhattan. It glows green, shedding nickel with no iron (seen only in industrial alloys). It is perfectly aligned with the planetary plane, odds of that by chance are 1 in 500. It has an anti-tail glow toward the Sun instead of away, and is moving at 60 km/s (600× faster than a NASCAR). On Oct 3, Mars Reconnaissance Orbiter will image it with 30 km resolution per pixel, our first real look at the object. Harvard’s Avi Loeb now puts 3I/ATLAS at Level 4 on the Loeb Scale (0 = natural rock, 10 = hostile tech). This is only the third interstellar object ever detected, and it’s the strangest by far. If it’s artificial, history changes overnight. Eyes on October! Source: #3IATLAS #Oumuamua #Interstellar #LoebScale #SpaceMystery #AlienTech

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NEW: President Trump touts the CDC announcement today reducing the number of jabs for children from 72 to 11 vaccinations. “This Schedule is rooted in the Gold Standard of Science, and widely agreed upon by Scientists and Experts all over the World.” Trump wrote on Truth Social: “Today, the Trump Administration is proud to announce the United States of America’s updated Childhood Vaccination Schedule. This Schedule is rooted in the Gold Standard of Science, and widely agreed upon by Scientists and Experts all over the World. Effective today, America will no longer require 72 ‘jabs’ for our beautiful, healthy children. We are moving to a far more reasonable Schedule, where all children will only be recommended to receive Vaccinations for 11 of the most serious and dangerous diseases.” “Parents can still choose to give their children all of the Vaccinations, if they wish, and they will still be covered by insurance. However, this updated Schedule finally aligns the United States with other Developed Nations around the World. Congratulations to HHS Secretary Bobby Kennedy, CDC Acting Director Jim O’Neil, FDA Commissioner Marty Makary, CMS Administrator Dr. Oz, NIH Director Jay Bhattacharya, and all of the Medical Experts and Professionals who worked very hard to make this happen. Many Americans, especially the ‘MAHA Moms,’ have been praying for these COMMON SENSE reforms for many years. Thank you for your attention to this matter!”

NEW: President Trump touts the CDC announcement today reducing the number of jabs for children from 72 to 11 vaccinations. “This Schedule is rooted in the Gold Standard of Science, and widely agreed upon by Scientists and Experts all over the World.” Trump wrote on Truth Social: “Today, the Trump Administration is proud to announce the United States of America’s updated Childhood Vaccination Schedule. This Schedule is rooted in the Gold Standard of Science, and widely agreed upon by Scientists and Experts all over the World. Effective today, America will no longer require 72 ‘jabs’ for our beautiful, healthy children. We are moving to a far more reasonable Schedule, where all children will only be recommended to receive Vaccinations for 11 of the most serious and dangerous diseases.” “Parents can still choose to give their children all of the Vaccinations, if they wish, and they will still be covered by insurance. However, this updated Schedule finally aligns the United States with other Developed Nations around the World. Congratulations to HHS Secretary Bobby Kennedy, CDC Acting Director Jim O’Neil, FDA Commissioner Marty Makary, CMS Administrator Dr. Oz, NIH Director Jay Bhattacharya, and all of the Medical Experts and Professionals who worked very hard to make this happen. Many Americans, especially the ‘MAHA Moms,’ have been praying for these COMMON SENSE reforms for many years. Thank you for your attention to this matter!”

RedWave Press

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Wait a minute…🚨 So this man allegedly stayed in America illegally for over 30 years… opened businesses… made money… raised children… had prior criminal history… and allegedly even kept a firearm in the restaurant… …and NOW we’re supposed to be emotionally manipulated into believing HE is the victim? No Democrats … not today. This is the part nobody wants to talk about. Millions of legal immigrants respected this country enough to follow the law. They waited… paid fees… filled out paperwork… went through interviews… and earned citizenship the right way. Meanwhile others allegedly learned they could simply stay long enough… build roots… ignore the system… and eventually the media would pressure Americans into feeling guilty for enforcing the very laws that define citizenship itself. That is not compassion. That is emotional coercion. And the craziest part? This story doesn’t expose how weak America is. It exposes how unbelievably generous and opportunity rich America is. Because only in America could someone allegedly remain unlawfully for decades and STILL build wealth, restaurants, and a life most people around the world dream about. Watch this carefully… because this story says far more about America than the media wants to admit. #SilentMajoritySpeaks #AStoneGroove

Wait a minute…🚨 So this man allegedly stayed in America illegally for over 30 years… opened businesses… made money… raised children… had prior criminal history… and allegedly even kept a firearm in the restaurant… …and NOW we’re supposed to be emotionally manipulated into believing HE is the victim? No Democrats … not today. This is the part nobody wants to talk about. Millions of legal immigrants respected this country enough to follow the law. They waited… paid fees… filled out paperwork… went through interviews… and earned citizenship the right way. Meanwhile others allegedly learned they could simply stay long enough… build roots… ignore the system… and eventually the media would pressure Americans into feeling guilty for enforcing the very laws that define citizenship itself. That is not compassion. That is emotional coercion. And the craziest part? This story doesn’t expose how weak America is. It exposes how unbelievably generous and opportunity rich America is. Because only in America could someone allegedly remain unlawfully for decades and STILL build wealth, restaurants, and a life most people around the world dream about. Watch this carefully… because this story says far more about America than the media wants to admit. #SilentMajoritySpeaks #AStoneGroove

A Gene Robinson

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today we are celebrating 4 years of Cal.com 🤯 how time flies from an ugly open source repository to over 7M appointments scheduled and a profitable team of ~24 full-timers we're looking back on 3 amazing company retreats in iceland 🇮🇸, tenerife 🇪🇸 and slovenia 🇸🇮 and an exciting 4th one coming up very soon! 🤫 i’m incredibly proud of what the team has build and the trust they have in me and bailey out of 38 total hires, 24 top performers are still with us and only a single person has decided to quit. many team members are approaching their 4th year as we are heading into a new era of the company from millions to billions. from a fun side-project to scheduling infrastructure that powers government institutions, hundreds of hospitals and the best performing startups such as deel, Mercury and more. while the team worked hard, we could not have achieved this without you, the community and customers of constantly pushing us to do better 🙏 it has been an honour so far and i’m looking forward towards the next 4 years! peer

today we are celebrating 4 years of Cal.com 🤯 how time flies from an ugly open source repository to over 7M appointments scheduled and a profitable team of ~24 full-timers we're looking back on 3 amazing company retreats in iceland 🇮🇸, tenerife 🇪🇸 and slovenia 🇸🇮 and an exciting 4th one coming up very soon! 🤫 i’m incredibly proud of what the team has build and the trust they have in me and bailey out of 38 total hires, 24 top performers are still with us and only a single person has decided to quit. many team members are approaching their 4th year as we are heading into a new era of the company from millions to billions. from a fun side-project to scheduling infrastructure that powers government institutions, hundreds of hospitals and the best performing startups such as deel, Mercury and more. while the team worked hard, we could not have achieved this without you, the community and customers of constantly pushing us to do better 🙏 it has been an honour so far and i’m looking forward towards the next 4 years! peer

Peer Richelsen

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Here we go again 😅 “Sir, your protein powder alarmed the systems.” I’ve heard it before. no biggie. Go ahead and give me a little pat down, swab some things, and send me on my way. After the routine though, i heard a new one: “Sir your PANTS are now alarming the systems - We need to do a more thorough pat down.” 😂 First of all, please don’t be scared to travel with your powders (protein, creatine, electrolytes, etc). I’ve been doing it for 20 years and this has happened maybe 4 times total. 2 RULES FOR GOING THROUGH SECURITY WITH POWDERS: Here’s the easiest way to cruise through security (and they’ll appreciate it too). 1 - Simply take them out and put them in a separate container when going through the x-ray machines. 2 - TSA will swab them and give them right back to you. Finally…please be nice to the TSA agents. This crew was amazing and had a great sense of humor about it. They have strict rules to follow and they’re just doing their job - to keep us all safe! And hey, you just might get a total body massage to start the day. 😜 Video cred: the one and only @realrachelpaul!! Has this happened to you???

Here we go again 😅 “Sir, your protein powder alarmed the systems.” I’ve heard it before. no biggie. Go ahead and give me a little pat down, swab some things, and send me on my way. After the routine though, i heard a new one: “Sir your PANTS are now alarming the systems - We need to do a more thorough pat down.” 😂 First of all, please don’t be scared to travel with your powders (protein, creatine, electrolytes, etc). I’ve been doing it for 20 years and this has happened maybe 4 times total. 2 RULES FOR GOING THROUGH SECURITY WITH POWDERS: Here’s the easiest way to cruise through security (and they’ll appreciate it too). 1 - Simply take them out and put them in a separate container when going through the x-ray machines. 2 - TSA will swab them and give them right back to you. Finally…please be nice to the TSA agents. This crew was amazing and had a great sense of humor about it. They have strict rules to follow and they’re just doing their job - to keep us all safe! And hey, you just might get a total body massage to start the day. 😜 Video cred: the one and only @realrachelpaul!! Has this happened to you???

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This week, we have had a lot of discussions around artificial intelligence, inspired by the Global AI Summit in Kigali, Rwanda. Many African countries are doing great things to motivate young people to take advantage of AI because it represents the future in problem solving. Unfortunately, Zimbabwe’s ICT Minister Tatenda Mavetera and her permanent secretary did not attend, showing how these things are not taken seriously by our government. Zimbabwe’s richest man, Strive Masiyiwa, who has not been to Zimbabwe for decades, made it clear at the summit, which he co-chaired, that investment will not go where the environment is not conducive. Our government talks about anything topical without delivering anything meaningful—they are doing the same with AI. The majority of schools have no computers. Zimbabweans receive electricity for only four hours a day. As the Under-Secretary-General and Executive Secretary of the United Nations Economic Commission for Africa, Claver Gatete, explains, a country needs electricity for AI data centres to work. Yet only 600 million out of 1.5 billion people in Africa have access to electricity, not even energy. Yet energy is an integral part of AI development. Energy is an essential component for the successful development and implementation of AI in a country because AI systems require massive amounts of data to function effectively. This data must be stored and processed in data centres and servers, which depend on electricity to power both the hardware and the cooling systems. You cannot achieve this in a country that delivers only four hours of electricity a day to its citizens like Zimbabwe. AI applications require continuous and uninterrupted access to data and computing resources to deliver accurate and timely results. Electricity is also crucial for powering research institutions, universities, and Research and Development centres that drive AI advancement. Without reliable access to electricity, these institutions will struggle to conduct research, develop new algorithms, or train AI models. The tragedy of Zimbabwe is that the Vice-President of Google responsible for AI, Dr James Manyika, is Zimbabwean; one of the key presenters at the summit, Prof Arthur Mutambara, who has just released a book on AI, is Zimbabwean; Strive Masiyiwa, who has partnered with Nvidia to bring supercomputer technology to the continent by building Africa’s first artificial intelligence factory in South Africa with data centres in Kenya and Egypt, is Zimbabwean. Yet, none of them are working in or with Zimbabwe. Our political leaders have let us down on all these fronts, yet they keep yapping about AI when there is nothing on the ground! Instead of slogans and dancing at rallies, they should see how other countries are doing it. A country that doesn’t focus on technology for development will be a dusty village in 25 years, and its people will not be able to compete at all, rendering it just a dot on the global map. Too much political yada yada without anything delivered, and with people like Tatenda Mavetera, who forge qualifications, in the driving seat, Zimbabwe’s fortunes will continue to dwindle! Add to that the historic looting of public funds meant for building power plants to give us electricity, future generations will curse on our graves!

Hopewell Chin’ono

33,671 Aufrufe • vor 1 Jahr

📣BREAKING TEXAS BREAKING: Williamson County Elections Administrator Wilco TX Elections Caught Destroying Evidence of Surveillance Gaps A digital clock in the Early Voting Ballot Board room exposed 2+ HOURS of missing surveillance video on 2/20/26. What did EA Bridgette Escobedo do? She unplugged the clock. 🧵 1/ Dr. Laura Pressley was monitoring the legally required surveillance feed (Tex. Elec. Code §127.1232(b)) and noticed the clock on the EVBB table jumped from 5:18pm→6:24pm, then again from 6:47pm→7:47pm. Over 2 hours of video — gone. 2/ AFTER those 2+ hours of missing footage, Escobedo personally delivered 4 early voting ballot boxes to the vault — alone. No Republican designee. No watchers. No chain of custody. Then at 8:28pm she unplugged the clock. 3/ The clock stayed off for nearly 5 DAYS — eliminating the only independent timestamp that could expose future video gaps. 4/ TODAY at noon, the Republican Presiding Judge plugged the clock back in. At 4:53pm, Escobedo marched into the EVBB room, shook the clock at the judge, and physically REMOVED it from the room. It's all on video. The ballot board members laughed at her after she left. 5/ Why would an elections administrator remove a clock from a room with legally required 24/7 surveillance? Because that clock is the only way the public can verify the video feed hasn't been spliced. Williamson County, Texas. March 2026 Republican Primary. This is happening RIGHT NOW.

📣BREAKING TEXAS BREAKING: Williamson County Elections Administrator Wilco TX Elections Caught Destroying Evidence of Surveillance Gaps A digital clock in the Early Voting Ballot Board room exposed 2+ HOURS of missing surveillance video on 2/20/26. What did EA Bridgette Escobedo do? She unplugged the clock. 🧵 1/ Dr. Laura Pressley was monitoring the legally required surveillance feed (Tex. Elec. Code §127.1232(b)) and noticed the clock on the EVBB table jumped from 5:18pm→6:24pm, then again from 6:47pm→7:47pm. Over 2 hours of video — gone. 2/ AFTER those 2+ hours of missing footage, Escobedo personally delivered 4 early voting ballot boxes to the vault — alone. No Republican designee. No watchers. No chain of custody. Then at 8:28pm she unplugged the clock. 3/ The clock stayed off for nearly 5 DAYS — eliminating the only independent timestamp that could expose future video gaps. 4/ TODAY at noon, the Republican Presiding Judge plugged the clock back in. At 4:53pm, Escobedo marched into the EVBB room, shook the clock at the judge, and physically REMOVED it from the room. It's all on video. The ballot board members laughed at her after she left. 5/ Why would an elections administrator remove a clock from a room with legally required 24/7 surveillance? Because that clock is the only way the public can verify the video feed hasn't been spliced. Williamson County, Texas. March 2026 Republican Primary. This is happening RIGHT NOW.

Lori Gallagher

46,795,754 Aufrufe • vor 6 Monaten

Why the West keeps smearing China (and why it won’t work this time) by Kishore Mahbubani *Eng/中文 subtitles • Many in the West still act like their job is to deliver the “gift” of democracy to China. Are we unable to see that there is more than one way to effectively and humanely govern a country? • When China was weak and defenseless, nobody offered democracy. In 1842 the West forced opium into China in exchange for tea. That was the lesson Chinese people absorbed: when you are weak, the West takes advantage of you. • Now that China is strong and its people have had the best 40 years of economic and social development in their modern history, the same voices switch to constant demonization. Anglo-Saxon media paints an “evil communist regime.” The goal of the Communist Party is not to revive communism. It is to revive Chinese civilization. • The real competition is not with the Communist Party of China. It is with a civilization that, for most of human history, performed as well as the West. The last 200 years of relative decline (China and India both) was the historical abnormality, not the normal state. • Year 2000: EU combined GNP was 7 times China’s. Today: roughly the same size. 2050 projection: EU will be about half the size of China. Structural shifts this large do not happen often. • Despite that reality, EU leaders still speak with open condescension. The hypocrisy is staggering. Kaja Kallas recently framed the China challenge in “cancer” language. The deeper root that almost no one wants to discuss is the old fear of the Yellow Peril. Good ole Sinophobia, fear, bigotry, and prejudice. 130 years ago the US Congress passed the Chinese Racial Exclusion Act for exactly that reason. • Three realistic paths for the next 20–30 years: ~20% chance the US and the West double down on maximum pressure to stop China’s rise. Unlike the Cold War containment of the Soviet Union, the rest of the world is not going to join this time. ~60% chance the world muddles through the usual way. • Short-term pragmatic handling (including recent US approach toward China) can keep things relatively stable. ~20% chance the West finally becomes enlightened: admits it can no longer dominate, forms real partnerships with other civilizations, treats them with respect, and accepts they will never become copies of the West. -Kishore Mahbubani PPA is a Singaporean diplomat and geopolitical consultant who served as Singapore Permanent Representative to the United Nations between 1984 and 1989, and again between 1998 and 2004, and President of the United Nations Security Council between 2001 and 2002.

Why the West keeps smearing China (and why it won’t work this time) by Kishore Mahbubani *Eng/中文 subtitles • Many in the West still act like their job is to deliver the “gift” of democracy to China. Are we unable to see that there is more than one way to effectively and humanely govern a country? • When China was weak and defenseless, nobody offered democracy. In 1842 the West forced opium into China in exchange for tea. That was the lesson Chinese people absorbed: when you are weak, the West takes advantage of you. • Now that China is strong and its people have had the best 40 years of economic and social development in their modern history, the same voices switch to constant demonization. Anglo-Saxon media paints an “evil communist regime.” The goal of the Communist Party is not to revive communism. It is to revive Chinese civilization. • The real competition is not with the Communist Party of China. It is with a civilization that, for most of human history, performed as well as the West. The last 200 years of relative decline (China and India both) was the historical abnormality, not the normal state. • Year 2000: EU combined GNP was 7 times China’s. Today: roughly the same size. 2050 projection: EU will be about half the size of China. Structural shifts this large do not happen often. • Despite that reality, EU leaders still speak with open condescension. The hypocrisy is staggering. Kaja Kallas recently framed the China challenge in “cancer” language. The deeper root that almost no one wants to discuss is the old fear of the Yellow Peril. Good ole Sinophobia, fear, bigotry, and prejudice. 130 years ago the US Congress passed the Chinese Racial Exclusion Act for exactly that reason. • Three realistic paths for the next 20–30 years: ~20% chance the US and the West double down on maximum pressure to stop China’s rise. Unlike the Cold War containment of the Soviet Union, the rest of the world is not going to join this time. ~60% chance the world muddles through the usual way. • Short-term pragmatic handling (including recent US approach toward China) can keep things relatively stable. ~20% chance the West finally becomes enlightened: admits it can no longer dominate, forms real partnerships with other civilizations, treats them with respect, and accepts they will never become copies of the West. -Kishore Mahbubani PPA is a Singaporean diplomat and geopolitical consultant who served as Singapore Permanent Representative to the United Nations between 1984 and 1989, and again between 1998 and 2004, and President of the United Nations Security Council between 2001 and 2002.

Larry 長祥

10,992 Aufrufe • vor 24 Tagen

$🚨🚨10-Year Longitudinal Data On Ketogenic Diet Adverse Events, Bone Mineral Density, Thyroid Function, and Kidney Function: PART 2🚨🚨 NEW DATA OUT TODAY: We (Joseph C. Watso, PhD/ Austin Robinson/ Samuel Klein) just published our PART 2 paper looking at long-term safety and clinical efficacy of ketogenic diet on: ☠️Adverse Events 🦴Bone Mineral Density 🔥Thyroid Function 🫘Kidney Function ...in part 1 we measured advanced cardiovascular health profile in an adult with elevated cardiovascular risk (type 1 diabetes) who followed a ketogenic diet for 10 years and sustained euglycemia (10-Year HbA1c 5.5%). See paper here: PART 2: What did we find? 👉PLEASE WATCH 📷 VIDEO ABSTRACT here ( 180mg/dL). Patient also presented with intact hypoglycemic awareness. 🦴2) Bone Mineral Density: Prior data suggests that short term ketogenic diet may impair markers of bone modeling/remodeling. However, most of these report are short in nature. People with type 1 diabetes are at HIGH risk for lower bone mineral density and fracture (hyperglycemia is risk factor). Here, we observed no negative impact on bone mineral density (using GOLD STANDARD DXA) on a ketogenic diet, despite 10 years of aging with type 1 diabetes. 🔥3) Thyroid Function: Concerns have been raised on how reducing carbohydrates may shift thyroid hormone status and metabolism. However, most of these studies are </=7 days in length. Following a ketogenic diet over a 10-year period, here we observe no negative impact on thyroid function with a 10-year ketogenic diet. 🫘4) Kidney Function: Microvascular disease is a very common complication of type 1 diabetes as hyperglycemia damages the small blood vessel in the kidneys. Adverse structural kidney changes are observed in children with type 1 diabetes as early as 1.5-5 years post diagnosis with eGFR declining over time. We did not observe any deterioration of kidney function in patient with type 1 diabetes over a 10-year period while achieving 10-Year 5.5% HbA1c following a ketogenic diet. 🚨⚠️9) LIMITATIONS: Reminder on limitations. This is an individual case. The importance of this data is in the sheer absence of short or long-term data, hypothesized risk of a KD, and popularity and use of KD which we hope help generate future research questions. 🗒️CONCLUSIONS: In the longest known longitudinal report of a ketogenic diet in a patient with type 1 diabetes, we observed no severe adverse events or negative impacts on bone, kidney, or thyroid health. We in our PART 1 paper, we observed above average cardiovascular disease health. These initial findings should provoke further research into interventions like ketogenic diets to reduce the long-term health risks faced by those living with T1D while closely monitoring both traditional and advanced cardiovascular risk markers. Especially considering that currently available therapies do no reliably allow patients to achieve <7% HbA1c, let alone <5.7% HbA1c. Joseph C. Watso, PhD Cardiovascular & Applied Physiology Lab Studying how health behaviors (e.g., diet, exercise, etc.) affect cardiovascular health and physiology Sansum Diabetes Research Institute Studying how lifestyle, tools, and medicine affect people with diabetes. @fsucehhs FSU Research FSU ISSM AJP-Cell Physiology The diaTribe Foundation Beyond Type 1 Michael Riddell, PhD Nick Norwitz MD PhD Metabolic Mind Dominic D'Agostino Benjamin Bikman$

🚨🚨10-Year Longitudinal Data On Ketogenic Diet Adverse Events, Bone Mineral Density, Thyroid Function, and Kidney Function: PART 2🚨🚨 NEW DATA OUT TODAY: We (Joseph C. Watso, PhD/ Austin Robinson/ Samuel Klein) just published our PART 2 paper looking at long-term safety and clinical efficacy of ketogenic diet on: ☠️Adverse Events 🦴Bone Mineral Density 🔥Thyroid Function 🫘Kidney Function ...in part 1 we measured advanced cardiovascular health profile in an adult with elevated cardiovascular risk (type 1 diabetes) who followed a ketogenic diet for 10 years and sustained euglycemia (10-Year HbA1c 5.5%). See paper here: PART 2: What did we find? 👉PLEASE WATCH 📷 VIDEO ABSTRACT here ( 180mg/dL). Patient also presented with intact hypoglycemic awareness. 🦴2) Bone Mineral Density: Prior data suggests that short term ketogenic diet may impair markers of bone modeling/remodeling. However, most of these report are short in nature. People with type 1 diabetes are at HIGH risk for lower bone mineral density and fracture (hyperglycemia is risk factor). Here, we observed no negative impact on bone mineral density (using GOLD STANDARD DXA) on a ketogenic diet, despite 10 years of aging with type 1 diabetes. 🔥3) Thyroid Function: Concerns have been raised on how reducing carbohydrates may shift thyroid hormone status and metabolism. However, most of these studies are </=7 days in length. Following a ketogenic diet over a 10-year period, here we observe no negative impact on thyroid function with a 10-year ketogenic diet. 🫘4) Kidney Function: Microvascular disease is a very common complication of type 1 diabetes as hyperglycemia damages the small blood vessel in the kidneys. Adverse structural kidney changes are observed in children with type 1 diabetes as early as 1.5-5 years post diagnosis with eGFR declining over time. We did not observe any deterioration of kidney function in patient with type 1 diabetes over a 10-year period while achieving 10-Year 5.5% HbA1c following a ketogenic diet. 🚨⚠️9) LIMITATIONS: Reminder on limitations. This is an individual case. The importance of this data is in the sheer absence of short or long-term data, hypothesized risk of a KD, and popularity and use of KD which we hope help generate future research questions. 🗒️CONCLUSIONS: In the longest known longitudinal report of a ketogenic diet in a patient with type 1 diabetes, we observed no severe adverse events or negative impacts on bone, kidney, or thyroid health. We in our PART 1 paper, we observed above average cardiovascular disease health. These initial findings should provoke further research into interventions like ketogenic diets to reduce the long-term health risks faced by those living with T1D while closely monitoring both traditional and advanced cardiovascular risk markers. Especially considering that currently available therapies do no reliably allow patients to achieve <7% HbA1c, let alone <5.7% HbA1c. Joseph C. Watso, PhD Cardiovascular & Applied Physiology Lab Studying how health behaviors (e.g., diet, exercise, etc.) affect cardiovascular health and physiology Sansum Diabetes Research Institute Studying how lifestyle, tools, and medicine affect people with diabetes. @fsucehhs FSU Research FSU ISSM AJP-Cell Physiology The diaTribe Foundation Beyond Type 1 Michael Riddell, PhD Nick Norwitz MD PhD Metabolic Mind Dominic D'Agostino Benjamin Bikman

Andrew Koutnik, Ph.D.

62,167 Aufrufe • vor 2 Jahren