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Proof that Life is Intelligently Designed: Proteins. They do everything in your cells that keeps you alive. These microscopic molecules must have been created. Here is why: Proteins are the building blocks of all the little nano-machines that make up your cells. They do all the major work in... your body - from creating energy to recycling waste. Proteins are made from amino acids connected into a specific sequence and then folded into a functional shape. You can think of a protein like a paragraph, and amino acids as the individual letters that spell out the words. Here is where it gets interesting... There are just 20 amino acids used in all of Life. Just 20 amino acids. Responsible for ~200 million unique proteins making up tens of thousands of cell types across Life. And scientists are constantly finding new ones. Scientists categorize proteins into Families. Protein Families are groups of proteins that share amino acid sequence similarities. There are ~22,000 Protein Families. Here's the part that screams they are designed... Protein Families have no evolutionary history. Even evolutionist scientists agree - they are absolutely unique. It's been said that proteins are like stars in a galaxy, and families are like galaxies, with vast empty space between them. Evolution is supposed to build by tweaking things that already exist. But no evolutionary history connects fundamentally distinct protein families. Experiments have been done to intentionally evolve one protein family into another. They fail every time. One protein family cannot be evolved into another. They cannot arise through evolution. But the math really makes it impossible... The odds of evolution finding even a single functional protein family is 1 chance in 10^77 possible amino acid sequences. That's a 1 with 77 zeroes. The odds of evolution finding 22,000 distinct protein families? Roughly 1 chance in 10^1,694,000. You don't need to be a mathematician to understand that this is impossible. Evolution works by random mutations tweaking what's already there. But protein families can't evolve from one another. And the math makes it absolutely absurd to believe. Monkeys banging on keyboards will never type out Shakespeare. And random mutations in sequences of amino acids could never create a single functional protein family. There is only one thing we know of that creates functionally specified sequences: Intelligence. Now here is the final cherry on top: Proteins are built by other proteins, assembled into a complex machine to do a job in cells. The assembly instructions for those proteins and the machines are found in DNA. But DNA requires protein machines for replication & repair. So DNA is required to make Proteins... ...but Proteins are required to make DNA and more Proteins. You can't have one without the other. They rely on each other. Which means one couldn't have evolved and then waited for the other. They couldn't do anything without each other. They had to be created at the same time to function together. Life was Divinely Designed. Proteins prove it.show more

Divinely Designed

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This is how DNA turns raw data into functional proteins - the building blocks of all your cells. This system requires a minimum of 3 key players working together: DNA: the master blueprint with the instructions RNA Polymerase: reads the DNA and makes a temporary copy called mRNA which carries the instructions to the Ribosome for how to create the Protein Ribosome: the tiny factory that reads the mRNA and strings amino acids together in a specific sequence to create a protein Without all three molecules working together, Proteins cannot be created, cells don't function, and Life ends. Everything needs to fit together, precisely & perfectly, or it all falls apart. In other words: this system cannot evolve, one step at a time. DNA relies other machines made of proteins to create those very proteins - but those proteins can't be made without the information in the DNA. And on top of that, this whole system relies on OTHER systems! You need other things like ATP Synthase that makes energy to power everything, tRNA to carry the amino acids to the Ribosome, other helper proteins, processing enzymes, etc. It's an extremely complex, interdependent network of parts & systems that all rely on each other. The cell is an astounding level of complexity that surpasses anything in human engineering. It's obvious this is intelligently designed. To deny that is absurd.

This is how DNA turns raw data into functional proteins - the building blocks of all your cells. This system requires a minimum of 3 key players working together: DNA: the master blueprint with the instructions RNA Polymerase: reads the DNA and makes a temporary copy called mRNA which carries the instructions to the Ribosome for how to create the Protein Ribosome: the tiny factory that reads the mRNA and strings amino acids together in a specific sequence to create a protein Without all three molecules working together, Proteins cannot be created, cells don't function, and Life ends. Everything needs to fit together, precisely & perfectly, or it all falls apart. In other words: this system cannot evolve, one step at a time. DNA relies other machines made of proteins to create those very proteins - but those proteins can't be made without the information in the DNA. And on top of that, this whole system relies on OTHER systems! You need other things like ATP Synthase that makes energy to power everything, tRNA to carry the amino acids to the Ribosome, other helper proteins, processing enzymes, etc. It's an extremely complex, interdependent network of parts & systems that all rely on each other. The cell is an astounding level of complexity that surpasses anything in human engineering. It's obvious this is intelligently designed. To deny that is absurd.

Divinely Designed

22,903 views • 5 months ago

This is how DNA turns coded information into functional proteins - the building blocks of the nanomachines that keep the cells in your body alive. This complex process highlights the sophisticated interconnected systems of Life which must all exist together from the beginning, or Life doesn't happen. First, an RNA molecule is copied from a short segment of DNA. Without the specifically ordered DNA information, RNA cannot form, proteins cannot be built, cells stop working, and life ceases to exist. Life is information first. Once the RNA Molecule is created, it gets ejected from the Polymerase where it was built, and it travels through a complex molecular machine called a Nuclear Pore Complex (NPC), which is an information recognition device that controls the flow of information in and out of a cell's nucleus. The NPC is highly complex - composed of about 500-1,000 protein subunits, derived from a set of about 35 distinct proteins. Without this molecular machine, there is no regulation for what goes in and out of the cell's nucleus, which would lead to catastrophic death for the cell. It must exist for cells to exist. Once the RNA Molecule passes through the NPC, it travels to the Ribosome, a 2-part chemical factory which reads the information on RNA and uses it to construct functional proteins using a specifically sequenced chain of amino acids. Once complete, this protein will then be sent to the section of the cell it belongs to integrate into another molecular machine and do its job. The Ribosome is another highly complex molecular machine - consisting of between 56-80 proteins. Without this molecular machines, proteins cannot be built. Proteins are the building blocks of every cell in every organism on Earth. Without Ribosomes, Life doesn't exist. If you're paying attention, you'll start to realize that Life relies on a highly sophisticated interdependent network of complex machines, which all rely on each other for the function of the system. DNA requires the cell for stability, but the cell requires the proteins for its structure and function, but those proteins require DNA and RNA to be built - it's a circle of necessary interdependence. Systems like this cannot be built by evolutionary processes, which requires that each piece of the process is built by gradual incremental means over lots of time. Without all the pieces there, from the beginning, none of it works. There is only one known source of complex & interdependent informational systems like those we find in life: and that is from Intelligence. Molecular Biology is the best and most obvious evidence of the Intelligent Design in Life.

This is how DNA turns coded information into functional proteins - the building blocks of the nanomachines that keep the cells in your body alive. This complex process highlights the sophisticated interconnected systems of Life which must all exist together from the beginning, or Life doesn't happen. First, an RNA molecule is copied from a short segment of DNA. Without the specifically ordered DNA information, RNA cannot form, proteins cannot be built, cells stop working, and life ceases to exist. Life is information first. Once the RNA Molecule is created, it gets ejected from the Polymerase where it was built, and it travels through a complex molecular machine called a Nuclear Pore Complex (NPC), which is an information recognition device that controls the flow of information in and out of a cell's nucleus. The NPC is highly complex - composed of about 500-1,000 protein subunits, derived from a set of about 35 distinct proteins. Without this molecular machine, there is no regulation for what goes in and out of the cell's nucleus, which would lead to catastrophic death for the cell. It must exist for cells to exist. Once the RNA Molecule passes through the NPC, it travels to the Ribosome, a 2-part chemical factory which reads the information on RNA and uses it to construct functional proteins using a specifically sequenced chain of amino acids. Once complete, this protein will then be sent to the section of the cell it belongs to integrate into another molecular machine and do its job. The Ribosome is another highly complex molecular machine - consisting of between 56-80 proteins. Without this molecular machines, proteins cannot be built. Proteins are the building blocks of every cell in every organism on Earth. Without Ribosomes, Life doesn't exist. If you're paying attention, you'll start to realize that Life relies on a highly sophisticated interdependent network of complex machines, which all rely on each other for the function of the system. DNA requires the cell for stability, but the cell requires the proteins for its structure and function, but those proteins require DNA and RNA to be built - it's a circle of necessary interdependence. Systems like this cannot be built by evolutionary processes, which requires that each piece of the process is built by gradual incremental means over lots of time. Without all the pieces there, from the beginning, none of it works. There is only one known source of complex & interdependent informational systems like those we find in life: and that is from Intelligence. Molecular Biology is the best and most obvious evidence of the Intelligent Design in Life.

Divinely Designed

62,517 views • 5 months ago

This is a Kinesin Molecule. These little molecular machines are commonly referred to as the "workhorse" of the cell, hauling important cargo like organelles, proteins and other cellular structures to their proper location within the cell. Kinesins are very clear & undeniable evidence of the intelligent design in Life. Kinesins are complex molecular machines, made up of 4 total proteins, each between 500-1,300 amino acids in length. If these aa sequences are not perfectly aligned from the beginning, Kinesin never forms, and cellular life would be unable to survive. Here is how they work: When a new protein, organelle, or other cellular structure is created in the Cytosol of the cell, they are constructed with built-in "binding tags," which are like shipping labels that bind to other protein molecules called Adaptor or Scaffold Proteins. These Adaptor/Scaffold Proteins then attach to the Kinesin's tail, which activates them, and then the Kinesin is guided along the microtubule track to its to its final destination. Kinesin walk on self-assembling tracks of other proteins, called microtubules, moving cargo from the inner area of the cell where they are constructed to the outer edges where they function. This is a complex & sophisticated interdependent network of molecular machines, all relying on one another to function properly for the health of the cell. This Intracellular Transportation system MUST be fully functional from the beginning - with all these working parts, or all of it fails, and the cell dies. Without this entire functioning system, Life could not exist. And the Kinesin is the centerpiece to all of it. Experiments have shown that disrupting Kinesin activity has catastrophic consequences. This type of nano-precision is an obvious example of designed engineering. Blind, unguided evolutionary processes cannot plan ahead and create complex informational highways for precision transportation. The proposed evolutionary explanation is simply "co-option." A nebulous term which basically amounts to, "We don't know how it evolved, but it must have evolved from some other thing that was similar in the past." No observational data supports evolutionary co-option. It's absurd to believe any part of this was built by blind chance. Everything in the cell points to Intelligent Design.

This is a Kinesin Molecule. These little molecular machines are commonly referred to as the "workhorse" of the cell, hauling important cargo like organelles, proteins and other cellular structures to their proper location within the cell. Kinesins are very clear & undeniable evidence of the intelligent design in Life. Kinesins are complex molecular machines, made up of 4 total proteins, each between 500-1,300 amino acids in length. If these aa sequences are not perfectly aligned from the beginning, Kinesin never forms, and cellular life would be unable to survive. Here is how they work: When a new protein, organelle, or other cellular structure is created in the Cytosol of the cell, they are constructed with built-in "binding tags," which are like shipping labels that bind to other protein molecules called Adaptor or Scaffold Proteins. These Adaptor/Scaffold Proteins then attach to the Kinesin's tail, which activates them, and then the Kinesin is guided along the microtubule track to its to its final destination. Kinesin walk on self-assembling tracks of other proteins, called microtubules, moving cargo from the inner area of the cell where they are constructed to the outer edges where they function. This is a complex & sophisticated interdependent network of molecular machines, all relying on one another to function properly for the health of the cell. This Intracellular Transportation system MUST be fully functional from the beginning - with all these working parts, or all of it fails, and the cell dies. Without this entire functioning system, Life could not exist. And the Kinesin is the centerpiece to all of it. Experiments have shown that disrupting Kinesin activity has catastrophic consequences. This type of nano-precision is an obvious example of designed engineering. Blind, unguided evolutionary processes cannot plan ahead and create complex informational highways for precision transportation. The proposed evolutionary explanation is simply "co-option." A nebulous term which basically amounts to, "We don't know how it evolved, but it must have evolved from some other thing that was similar in the past." No observational data supports evolutionary co-option. It's absurd to believe any part of this was built by blind chance. Everything in the cell points to Intelligent Design.

Divinely Designed

15,877 views • 5 months ago

This is how cells make energy - the production of ATP. All life requires ATP for energy. Without it, cells cannot function, and Life cannot survive. That means ATP Synthase is required from the very start of Life. Evolution cannot build ATP, because evolutionary processes require ATP to even function - creating a massive chicken-or-the-egg paradox. You can't have life without ATP, but you can't get ATP until you have life. Evidence it was intelligently designed. ATP Synthase is also incredibly complex. In simpler prokaryotic organisms (bacteria, etc), the molecule has 8 unique proteins organized into 22 subunits, all working together in a coordinated system. In higher level eukaryotes (humans, mammals, etc), the molecule has 18 unique proteins organized into 29 coordinated subunits making up the system. The simpler versions still require a minimal set of specified proteins, totaling more than 3,500 amino acids, sequenced perfectly in line to create all the proteins, all engineered to perfection. The odds of something like this coming together by chance are incomprehensibly small, it's effectively impossible. This system is a clear and obvious sign of design.

This is how cells make energy - the production of ATP. All life requires ATP for energy. Without it, cells cannot function, and Life cannot survive. That means ATP Synthase is required from the very start of Life. Evolution cannot build ATP, because evolutionary processes require ATP to even function - creating a massive chicken-or-the-egg paradox. You can't have life without ATP, but you can't get ATP until you have life. Evidence it was intelligently designed. ATP Synthase is also incredibly complex. In simpler prokaryotic organisms (bacteria, etc), the molecule has 8 unique proteins organized into 22 subunits, all working together in a coordinated system. In higher level eukaryotes (humans, mammals, etc), the molecule has 18 unique proteins organized into 29 coordinated subunits making up the system. The simpler versions still require a minimal set of specified proteins, totaling more than 3,500 amino acids, sequenced perfectly in line to create all the proteins, all engineered to perfection. The odds of something like this coming together by chance are incomprehensibly small, it's effectively impossible. This system is a clear and obvious sign of design.

Divinely Designed

61,036 views • 4 months ago

This is mind ATP Synthase The energy pump that powers every cell in every lifeform on Earth, slowed down by over 1,000x. Without ATP Synthase, life cannot exist. This little nano-machine is made up of a minimum of 8 distinct proteins, all designed perfectly to fit together and operate in a coordinated system that takes in ADP and turns it into ATP, which the cell uses to power metabolic processes. It's designed to only allow certain molecules in & out. Any mistakes, and it could flood the cell with toxic waste in a matter of seconds, killing everything. Each protein building block must fit perfectly together, much like all the pieces inside your phone. Without all the proteins fit & working together from the start, ATP Synthase cannot function, and Life cannot exist. But making things even more complex, ATP Synthase doesn't operate alone. It's located inside the cell membrane, where it actively works with other molecules to ensure the ATP it creates gets to the right place. It's a whole integrated network of energy movement within each cell, without which, Life could not exist. All these pieces must exist together, from the beginning, for Life to be possible. Which means it can't arise piece by piece through evolution - because the very process of evolution requires the whole system. Life requires this system in order to produce the energy it needs to replicate & evolve - but replication & evolution is supposed to have created it. You can't have one without the other. There are no simpler versions - it's literally all or nothing. This is clear evidence of an intelligently designed system. What more evidence do you need?

This is mind ATP Synthase The energy pump that powers every cell in every lifeform on Earth, slowed down by over 1,000x. Without ATP Synthase, life cannot exist. This little nano-machine is made up of a minimum of 8 distinct proteins, all designed perfectly to fit together and operate in a coordinated system that takes in ADP and turns it into ATP, which the cell uses to power metabolic processes. It's designed to only allow certain molecules in & out. Any mistakes, and it could flood the cell with toxic waste in a matter of seconds, killing everything. Each protein building block must fit perfectly together, much like all the pieces inside your phone. Without all the proteins fit & working together from the start, ATP Synthase cannot function, and Life cannot exist. But making things even more complex, ATP Synthase doesn't operate alone. It's located inside the cell membrane, where it actively works with other molecules to ensure the ATP it creates gets to the right place. It's a whole integrated network of energy movement within each cell, without which, Life could not exist. All these pieces must exist together, from the beginning, for Life to be possible. Which means it can't arise piece by piece through evolution - because the very process of evolution requires the whole system. Life requires this system in order to produce the energy it needs to replicate & evolve - but replication & evolution is supposed to have created it. You can't have one without the other. There are no simpler versions - it's literally all or nothing. This is clear evidence of an intelligently designed system. What more evidence do you need?

Divinely Designed

28,434 views • 1 month ago

4/ Myth: All Protein Sources Are Equal Truth: Plant-based protein sources have a much weaker effect in the body due to their unbalanced amino acid profiles. Animal proteins, especially eggs, are utilized far better in the body for producing muscle, bone, hormones, and neurotransmitters.

4/ Myth: All Protein Sources Are Equal Truth: Plant-based protein sources have a much weaker effect in the body due to their unbalanced amino acid profiles. Animal proteins, especially eggs, are utilized far better in the body for producing muscle, bone, hormones, and neurotransmitters.

Craig Brockie

728,934 views • 1 year ago

We're thrilled to present ESM3 in Science Magazine. ESM3 is a generative language model that reasons over the three fundamental properties of proteins: sequence, structure, and function. Today we're making ESM3 available free to researchers worldwide via the public beta of an API for biological intelligence. Trained with over a trillion teraflops of compute, this is the first time a model of this scale has been trained for biology, pushing the frontier of AI for biological discovery and engineering. ESM3 learns to represent the immense complexity of protein biology, learning from billions of natural proteins. From this training it developed the capability to design proteins, responding to complex prompts combining atomic level details and high level instructions to generate new proteins. ESM3 can explore protein space far beyond natural evolution. We prompted ESM3 to generate a fluorescent protein at a far distance from any known fluorescent proteins, searching an unknown region of protein space, to discover a new fluorescent protein. We estimate this is equivalent to simulating five hundred million years of evolution.

We're thrilled to present ESM3 in Science Magazine. ESM3 is a generative language model that reasons over the three fundamental properties of proteins: sequence, structure, and function. Today we're making ESM3 available free to researchers worldwide via the public beta of an API for biological intelligence. Trained with over a trillion teraflops of compute, this is the first time a model of this scale has been trained for biology, pushing the frontier of AI for biological discovery and engineering. ESM3 learns to represent the immense complexity of protein biology, learning from billions of natural proteins. From this training it developed the capability to design proteins, responding to complex prompts combining atomic level details and high level instructions to generate new proteins. ESM3 can explore protein space far beyond natural evolution. We prompted ESM3 to generate a fluorescent protein at a far distance from any known fluorescent proteins, searching an unknown region of protein space, to discover a new fluorescent protein. We estimate this is equivalent to simulating five hundred million years of evolution.

Alex Rives

227,195 views • 1 year ago

Proteins are the machinery of life. Scientists have cataloged billions of protein sequences—but their biology is still mostly unknown. Today we're releasing a world model of protein biology: a scientific engine for prediction, design, and discovery that consists of ESMFold2, ESMC, and ESM Atlas. Together, they're helping to open up a new way for researchers to design proteins and speed up scientific discovery. Our mission is to cure or prevent disease. To do that, we need to accelerate science. That's why we're releasing all three openly.

Proteins are the machinery of life. Scientists have cataloged billions of protein sequences—but their biology is still mostly unknown. Today we're releasing a world model of protein biology: a scientific engine for prediction, design, and discovery that consists of ESMFold2, ESMC, and ESM Atlas. Together, they're helping to open up a new way for researchers to design proteins and speed up scientific discovery. Our mission is to cure or prevent disease. To do that, we need to accelerate science. That's why we're releasing all three openly.

biohub

76,644 views • 1 month ago

There is not enough time in the history of the entire universe for random mutations + natural selection to construct even a single novel protein - let alone the hundreds needed for even the simplest life. The simplest cell ever created by scientists in a lab (JCVI-Syn3.0) required 438 unique proteins, totaling over 77,000 total proteins, to keep it alive. This gives us a scientifically observed and confirmed minimal cellular requirement. It's absurd to believe Life arose by chance natural processes.

There is not enough time in the history of the entire universe for random mutations + natural selection to construct even a single novel protein - let alone the hundreds needed for even the simplest life. The simplest cell ever created by scientists in a lab (JCVI-Syn3.0) required 438 unique proteins, totaling over 77,000 total proteins, to keep it alive. This gives us a scientifically observed and confirmed minimal cellular requirement. It's absurd to believe Life arose by chance natural processes.

Divinely Designed

168,741 views • 5 months ago

Bryan Johnson reveals the best way to use a sauna and its health benefits “The primary benefit of a sauna is when your core body temperature gets to about 102 degrees Fahrenheit, it triggers the release of heat shock proteins. They are like little protein machines that get spun up and go around fixing your body. They fix broken proteins and misfolded proteins. They are flooding your body and doing good stuff, but it only triggers when your body hits a certain level” “Basically just do a dry sauna somewhere between 174-212 degrees Fahrenheit for 20 minutes. It's a good starting point, and don't forget ice on the boys”

Bryan Johnson reveals the best way to use a sauna and its health benefits “The primary benefit of a sauna is when your core body temperature gets to about 102 degrees Fahrenheit, it triggers the release of heat shock proteins. They are like little protein machines that get spun up and go around fixing your body. They fix broken proteins and misfolded proteins. They are flooding your body and doing good stuff, but it only triggers when your body hits a certain level” “Basically just do a dry sauna somewhere between 174-212 degrees Fahrenheit for 20 minutes. It's a good starting point, and don't forget ice on the boys”

Mikli

261,286 views • 3 months ago

This is crazy! This is some of the complex systems working inside your cells. God's Design inside every single cell in your body. Cells cannot arise through evolution. The minimum viable cell requires: - Around ~500,000 lines of coded information (DNA) - Close to ~500 unique protein products (the building blocks of all those cellular machines and systems) - Total of ~20k-50k total proteins all working perfectly together - Around ~30-40 regulatory systems guiding all those interactions The cell requires all those parts & systems, or it doesn't function. If we do the math, there are about ~10^70,000 possible interactions in this cell. Interactions are things like: - energy production - waste removal - protein creation - system repair The odds are incomprehensible. Evolutionists will argue the odds are misleading, because it evolves gradually via step-by-step trial & error. But the cell REQUIRES a minimum set of parts & systems to function - without all of these in place, together, from the beginning, it dies. Therefore, the cell cannot evolve through step-by-step evolutionary processes, because there is no reproduction + mutation to drive evolutionary change until the cell is complete. Cells are a massive problem for Evolutionism, because they are such obvious signs of Intelligent Design. Even the famous atheist Richard Dawkins admitted that, "Biology is the study of complicated things that have the appearance of having been designed with a purpose." Biology seems designed because it IS designed. God's Divine Design becomes more obvious, the closer we look.

This is crazy! This is some of the complex systems working inside your cells. God's Design inside every single cell in your body. Cells cannot arise through evolution. The minimum viable cell requires: - Around ~500,000 lines of coded information (DNA) - Close to ~500 unique protein products (the building blocks of all those cellular machines and systems) - Total of ~20k-50k total proteins all working perfectly together - Around ~30-40 regulatory systems guiding all those interactions The cell requires all those parts & systems, or it doesn't function. If we do the math, there are about ~10^70,000 possible interactions in this cell. Interactions are things like: - energy production - waste removal - protein creation - system repair The odds are incomprehensible. Evolutionists will argue the odds are misleading, because it evolves gradually via step-by-step trial & error. But the cell REQUIRES a minimum set of parts & systems to function - without all of these in place, together, from the beginning, it dies. Therefore, the cell cannot evolve through step-by-step evolutionary processes, because there is no reproduction + mutation to drive evolutionary change until the cell is complete. Cells are a massive problem for Evolutionism, because they are such obvious signs of Intelligent Design. Even the famous atheist Richard Dawkins admitted that, "Biology is the study of complicated things that have the appearance of having been designed with a purpose." Biology seems designed because it IS designed. God's Divine Design becomes more obvious, the closer we look.

Divinely Designed

32,233 views • 3 months ago

"Frankenstein Proteins" The technology underpinning every mRNA 'vaccine' is creating strange "Frankenstein proteins" in the body and "no one knows what those proteins are doing". Pseudouridine was given a Nobel Prize before peer reviewed research from Cambridge found strange proteins circulating in the body of the vaccinated. Dr Ryan Cole discusses with Dr Kelly Victory: "This means is you're also coding for Frankenstein proteins, which may be functional, which may be triggering autoimmune reactions." "You're making proteins in addition to, you know the supposed spike protein, you're making unintended but potentially consequential proteins, that can cause the immune system also to go haywire." "So this was found out a couple years into the rollout of the shots and these very esteemed researchers said 'Houston we have a problem'. " Yet Paul Offit and the AAP wants this injected into healthy 2 year olds and children. Who has the moral high ground here?

"Frankenstein Proteins" The technology underpinning every mRNA 'vaccine' is creating strange "Frankenstein proteins" in the body and "no one knows what those proteins are doing". Pseudouridine was given a Nobel Prize before peer reviewed research from Cambridge found strange proteins circulating in the body of the vaccinated. Dr Ryan Cole discusses with Dr Kelly Victory: "This means is you're also coding for Frankenstein proteins, which may be functional, which may be triggering autoimmune reactions." "You're making proteins in addition to, you know the supposed spike protein, you're making unintended but potentially consequential proteins, that can cause the immune system also to go haywire." "So this was found out a couple years into the rollout of the shots and these very esteemed researchers said 'Houston we have a problem'. " Yet Paul Offit and the AAP wants this injected into healthy 2 year olds and children. Who has the moral high ground here?

Humanspective

15,413 views • 10 months ago

What seemed like an intractable problem is now possible: To design proteins with a specified nonlinear mechanical response, capturing complex folding and unfolding mechanisms in singe and few-shot computations. We present ForceGen, an end-to-end algorithm for de novo protein generation based on nonlinear mechanical unfolding responses. Rooted in the physics of protein mechanics, this generative strategy provides a powerful way to design new proteins rapidly, including exquisite and rapid predictions about their dynamical behavior. Proteins, like any other mechanical object, respond to forces in peculiar ways. Think of the different response you'd get from pulling on a steel cable versus pulling on a rubber band, or the difference between honey and glass. Now, we can design proteins with a set of desirable mechanical characteristics, with applications from health to sustainable plastics. The key to solving this problem was to integrate a protein language model with denoising diffusion methods, and using accurate atomistic-level physical simulation data to endow the model a first-principles understanding. ForceGen can solve both forward and inverse tasks: In the forward task, we can predict how stable a protein is, how it will unfold and what the forces involved are, all given just the sequence of amino acids. In the inverse task, we can design new proteins that meet complex nonlinear mechanical signature targets. Read the paper, led by LAMM@MIT postdoc Bo Ni, published in Science Advances: Why do we care about the mechanics of proteins? The mechanics of proteins are critical elements of many living systems - as evidenced in many studies of mechanobiology. Through evolution, nature has presented a set of remarkable protein materials with unique mechanical functions like elastins, silks, keratins or collagens that play crucial roles in biology. However, going beyond natural designs to discover proteins that meet specified mechanical properties remains challenging. So far, the only way to do this was to use existing evolutionary concepts or to manually alter proteins. With our new generative model we can directly design proteins to meet complex nonlinear mechanical property-design objectives. ForceGen leverages deep knowledge on protein sequences from a pretrained protein language model and maps mechanical unfolding responses to create proteins. Via full-atom molecular simulations for direct validation from physical and chemical principles, we demonstrate that the designed proteins are de novo, and fulfill the targeted mechanical properties, including unfolding energy and mechanical strength, and a detailed unfolding force-separation curves. ForceGen offers rapid pathways to explore the enormous mechanobiological protein sequence space unconstrained by biological synthesis, to enable the discovery of new protein materials with superior mechanical properties. B. Ni, D.L. Kaplan, M.J. Buehler, ForceGen: End-to-end de novo protein generation based on nonlinear mechanical unfolding responses using a language diffusion model. Sci. Adv. 10, eadl4000 (2024). DOI: 10.1126/sciadv.adl4000 Codes and model weights available Hugging Face: David Kaplan

What seemed like an intractable problem is now possible: To design proteins with a specified nonlinear mechanical response, capturing complex folding and unfolding mechanisms in singe and few-shot computations. We present ForceGen, an end-to-end algorithm for de novo protein generation based on nonlinear mechanical unfolding responses. Rooted in the physics of protein mechanics, this generative strategy provides a powerful way to design new proteins rapidly, including exquisite and rapid predictions about their dynamical behavior. Proteins, like any other mechanical object, respond to forces in peculiar ways. Think of the different response you'd get from pulling on a steel cable versus pulling on a rubber band, or the difference between honey and glass. Now, we can design proteins with a set of desirable mechanical characteristics, with applications from health to sustainable plastics. The key to solving this problem was to integrate a protein language model with denoising diffusion methods, and using accurate atomistic-level physical simulation data to endow the model a first-principles understanding. ForceGen can solve both forward and inverse tasks: In the forward task, we can predict how stable a protein is, how it will unfold and what the forces involved are, all given just the sequence of amino acids. In the inverse task, we can design new proteins that meet complex nonlinear mechanical signature targets. Read the paper, led by LAMM@MIT postdoc Bo Ni, published in Science Advances: Why do we care about the mechanics of proteins? The mechanics of proteins are critical elements of many living systems - as evidenced in many studies of mechanobiology. Through evolution, nature has presented a set of remarkable protein materials with unique mechanical functions like elastins, silks, keratins or collagens that play crucial roles in biology. However, going beyond natural designs to discover proteins that meet specified mechanical properties remains challenging. So far, the only way to do this was to use existing evolutionary concepts or to manually alter proteins. With our new generative model we can directly design proteins to meet complex nonlinear mechanical property-design objectives. ForceGen leverages deep knowledge on protein sequences from a pretrained protein language model and maps mechanical unfolding responses to create proteins. Via full-atom molecular simulations for direct validation from physical and chemical principles, we demonstrate that the designed proteins are de novo, and fulfill the targeted mechanical properties, including unfolding energy and mechanical strength, and a detailed unfolding force-separation curves. ForceGen offers rapid pathways to explore the enormous mechanobiological protein sequence space unconstrained by biological synthesis, to enable the discovery of new protein materials with superior mechanical properties. B. Ni, D.L. Kaplan, M.J. Buehler, ForceGen: End-to-end de novo protein generation based on nonlinear mechanical unfolding responses using a language diffusion model. Sci. Adv. 10, eadl4000 (2024). DOI: 10.1126/sciadv.adl4000 Codes and model weights available Hugging Face: David Kaplan

Markus J. Buehler

47,242 views • 2 years ago

"The industry has been plagued with the problem, that these formulations are toxic". NEW World Premiere. "Inside mRNA Vaccines". Robert Malone MD addresses the technology underpinning every single "safe and effective" mRNA injection. Pseudouridine. It was given a Nobel Prize, before a peer reviewed paper from Cambridge found strange proteins in the blood of vaccinated people and "no one knows what those proteins are doing". Professor Robert Clancy said of the same Cambridge research in another separate interview: "the Nobel Prize in 2023 was given to two people for putting pseudouridine in a messenger RNA, to make it work better" "Within three months, a group in Cambridge found that 20% of readouts, and about 10% of people, had strange proteins circulating in their bodies, some of which have the capacity to form amyloid, which can cause dementia [and] they found this within weeks and months of people being vaccinated" "They worked out that the mechanism was because the pseudouridine [was producing]—instead of a spike protein—something completely strange and different" "No one knows what those proteins are doing"

"The industry has been plagued with the problem, that these formulations are toxic". NEW World Premiere. "Inside mRNA Vaccines". Robert Malone MD addresses the technology underpinning every single "safe and effective" mRNA injection. Pseudouridine. It was given a Nobel Prize, before a peer reviewed paper from Cambridge found strange proteins in the blood of vaccinated people and "no one knows what those proteins are doing". Professor Robert Clancy said of the same Cambridge research in another separate interview: "the Nobel Prize in 2023 was given to two people for putting pseudouridine in a messenger RNA, to make it work better" "Within three months, a group in Cambridge found that 20% of readouts, and about 10% of people, had strange proteins circulating in their bodies, some of which have the capacity to form amyloid, which can cause dementia [and] they found this within weeks and months of people being vaccinated" "They worked out that the mechanism was because the pseudouridine [was producing]—instead of a spike protein—something completely strange and different" "No one knows what those proteins are doing"

Humanspective

10,202 views • 10 months ago

There is not enough time in the entire history of the universe for random mutations and natural selection to assemble even a single novel, functional protein—let alone the hundreds required for even the simplest form of life. The simplest living cell ever created in a laboratory, JCVI-Syn3.0, requires 438 unique proteins, amounting to over 77,000 total protein molecules, just to survive and reproduce. This is not speculation—it is an experimentally observed, scientifically confirmed minimum for cellular life. The idea that life came into existence purely by blind natural processes no longer makes sense in light of what modern science has discovered.

There is not enough time in the entire history of the universe for random mutations and natural selection to assemble even a single novel, functional protein—let alone the hundreds required for even the simplest form of life. The simplest living cell ever created in a laboratory, JCVI-Syn3.0, requires 438 unique proteins, amounting to over 77,000 total protein molecules, just to survive and reproduce. This is not speculation—it is an experimentally observed, scientifically confirmed minimum for cellular life. The idea that life came into existence purely by blind natural processes no longer makes sense in light of what modern science has discovered.

Night Sky Now

61,111 views • 5 months ago

Great explanation by Bret Weinstein: "The mRNA platform solves a problem. It is a gene therapy technology, and it allows you to deliver an mRNA message. mRNA means messenger RNA. Usually messenger RNA is produced in the nucleus of your cells. It moves to the cytoplasm, and then something called a ribosome translates it into protein." "Protein does the work of the cell. It creates most of the structures of the cell. So what they innovated was a mechanism for getting RNA messages that they controlled, that they dictated into cells so that your cells would produce a vaccine-like substance. So instead of a vaccine factory, they had a factory that produces a injectable that turns your cell into a factory." "I mean, it's a brilliant idea at one level Not ready to be injected into a human being and frankly There is a fundamental flaw in it that cannot be solved with present technology. This is where the rubber meets the road. When you get sick with a virus, that virus hijacks your cells. Your cells are covered in protein that you yourself produce." "By a complex process in utero, your immune system learns to ignore every protein that you yourself make. So the way immunity works is you learn to ignore your own proteins and then anytime you see something that you don't recognize. You fight it as a pathogen. When a virus invades your cells it hijacks them and they produce more virus. They do that they produce proteins that your immune system does not recognize." "So your immune system has a capacity to surveil all your cells and when it encounters a cell that is putting out proteins that you yourself make but also proteins. It doesn't recognize it regards those cells as virally infected and it destroys them because no matter how important the cell in question is right? There's no way to get the virus out of it. So killing it is a better plan than leaving it in place." "So now these folks who made the mRNA vaccines inject them into people and they tell us that the vaccine will stay in the deltoid. Well, no, it's not going to stay in the deltoid. You're injecting a fluid into a space that doesn't have room for it's going to leak out and in many cases, the needle itself will just by accident have landed in a vein and that injection will actually go in a concentrated way into the bloodstream." "There is no targeting mechanism at all on the lipid nanoparticles the fats that are used to transport these mRNA messages into the body. You may remember from chemistry that like dissolves like. Fats are what these mRNAs are coated in every cell in your body has a fat layer on the outside. Those fats join the mRNA message goes into the cell the cell starts producing this foreign protein your immune system Sees that foreign protein." "This is actually part of the design. Your immune system is supposed to see it That's where the immunity is supposed to come from But your immune system in recognizing these foreign proteins on your own cells will assume they are virally infected and it will destroy them." "If that happens in your deltoid, not a huge deal. If it happens in your liver, probably not a huge deal if it happens in your heart It's a huge deal, especially if you've got a big concentrated glob of it. So a bunch of cells in your heart were producing these foreign proteins and got attacked by your immune system because your heart, a is very well protected." "So it doesn't usually suffer from insults. B it has very low capacity for repair. In fact, mostly it doesn't repair it's scars. Hmm. So if you've got a concentrated dose of this in your heart a bunch of your heart cells got transfected. Your immune system will kill those cells that leaves you with a wound." "It's a wound you don't even know you have because your heart is not innervated for you to be able to feel that damage. There's no benefit to it because such damage would be very unusual so you've got a damaged heart. It's never gonna be the same." "At best months will pass and it will scar over but at worst maybe you're on the soccer field and you're going to score the big goal and your blood pressure goes up to a level that hasn't been in months and that wound does arbitrary things. Maybe you collapse. So the key the punchline to this story is none of those things have anything to do with the content of the message that was encoded into these things." "That just has to do with the platform. The platform has this defect built into it, and anything, any disease you attempted to remedy with this mechanism would cause the same problem. So that's a dire failure. I would also point out, there are many other flaws with this technology. The way the mRNA molecules were stabilized was irresponsible." "It made for a process that cannot be terminated and is not naturally terminated by biological biological pathways. It also caused the ribosomes to incorrectly translate into protein so that you get arbitrary products that have arbitrary consequences. The manufacturing of these injectables was piss poor the quality control was garbage." "There are all kinds of impurities contaminants including DNA from SV40 which has potentially cancer inducing properties so these shots were an absolute horror show design failure after design failure manufacturing flaw after manufacturing flaw and the idea that anybody injected healthy people with them is needs to be explained."

Great explanation by Bret Weinstein: "The mRNA platform solves a problem. It is a gene therapy technology, and it allows you to deliver an mRNA message. mRNA means messenger RNA. Usually messenger RNA is produced in the nucleus of your cells. It moves to the cytoplasm, and then something called a ribosome translates it into protein." "Protein does the work of the cell. It creates most of the structures of the cell. So what they innovated was a mechanism for getting RNA messages that they controlled, that they dictated into cells so that your cells would produce a vaccine-like substance. So instead of a vaccine factory, they had a factory that produces a injectable that turns your cell into a factory." "I mean, it's a brilliant idea at one level Not ready to be injected into a human being and frankly There is a fundamental flaw in it that cannot be solved with present technology. This is where the rubber meets the road. When you get sick with a virus, that virus hijacks your cells. Your cells are covered in protein that you yourself produce." "By a complex process in utero, your immune system learns to ignore every protein that you yourself make. So the way immunity works is you learn to ignore your own proteins and then anytime you see something that you don't recognize. You fight it as a pathogen. When a virus invades your cells it hijacks them and they produce more virus. They do that they produce proteins that your immune system does not recognize." "So your immune system has a capacity to surveil all your cells and when it encounters a cell that is putting out proteins that you yourself make but also proteins. It doesn't recognize it regards those cells as virally infected and it destroys them because no matter how important the cell in question is right? There's no way to get the virus out of it. So killing it is a better plan than leaving it in place." "So now these folks who made the mRNA vaccines inject them into people and they tell us that the vaccine will stay in the deltoid. Well, no, it's not going to stay in the deltoid. You're injecting a fluid into a space that doesn't have room for it's going to leak out and in many cases, the needle itself will just by accident have landed in a vein and that injection will actually go in a concentrated way into the bloodstream." "There is no targeting mechanism at all on the lipid nanoparticles the fats that are used to transport these mRNA messages into the body. You may remember from chemistry that like dissolves like. Fats are what these mRNAs are coated in every cell in your body has a fat layer on the outside. Those fats join the mRNA message goes into the cell the cell starts producing this foreign protein your immune system Sees that foreign protein." "This is actually part of the design. Your immune system is supposed to see it That's where the immunity is supposed to come from But your immune system in recognizing these foreign proteins on your own cells will assume they are virally infected and it will destroy them." "If that happens in your deltoid, not a huge deal. If it happens in your liver, probably not a huge deal if it happens in your heart It's a huge deal, especially if you've got a big concentrated glob of it. So a bunch of cells in your heart were producing these foreign proteins and got attacked by your immune system because your heart, a is very well protected." "So it doesn't usually suffer from insults. B it has very low capacity for repair. In fact, mostly it doesn't repair it's scars. Hmm. So if you've got a concentrated dose of this in your heart a bunch of your heart cells got transfected. Your immune system will kill those cells that leaves you with a wound." "It's a wound you don't even know you have because your heart is not innervated for you to be able to feel that damage. There's no benefit to it because such damage would be very unusual so you've got a damaged heart. It's never gonna be the same." "At best months will pass and it will scar over but at worst maybe you're on the soccer field and you're going to score the big goal and your blood pressure goes up to a level that hasn't been in months and that wound does arbitrary things. Maybe you collapse. So the key the punchline to this story is none of those things have anything to do with the content of the message that was encoded into these things." "That just has to do with the platform. The platform has this defect built into it, and anything, any disease you attempted to remedy with this mechanism would cause the same problem. So that's a dire failure. I would also point out, there are many other flaws with this technology. The way the mRNA molecules were stabilized was irresponsible." "It made for a process that cannot be terminated and is not naturally terminated by biological biological pathways. It also caused the ribosomes to incorrectly translate into protein so that you get arbitrary products that have arbitrary consequences. The manufacturing of these injectables was piss poor the quality control was garbage." "There are all kinds of impurities contaminants including DNA from SV40 which has potentially cancer inducing properties so these shots were an absolute horror show design failure after design failure manufacturing flaw after manufacturing flaw and the idea that anybody injected healthy people with them is needs to be explained."

Camus

607,223 views • 1 year ago

Most people don’t truly understand how mRNA vaccines work. Unlike traditional vaccines, where a factory produces the antigen and injects it into the body, mRNA vaccines turn YOUR OWN CELLS into the factory. Here’s how it works: Inside every one of your cells, there are ribosomes—tiny protein-making machines. Normally, these ribosomes get instructions from your cell’s nucleus (the brain of the cell) to produce proteins that build muscle, fight infections, and keep your body functioning. mRNA vaccines hijack this natural process by delivering a blueprint that instructs your ribosomes to produce a specific protein—like the spike protein of a virus. Your immune system then recognizes this protein as foreign, triggering a defense response and preparing your body to fight off future infections. Why does this matter? 1️⃣ Faster production – No need for external manufacturing of viral proteins, cutting vaccine development time. 2️⃣ Adaptability – The technology can be rapidly adjusted for new viruses and mutations. 3️⃣ No live virus – Unlike traditional vaccines, mRNA vaccines don’t use weakened or dead viruses, reducing risk. But here’s the big question: Are we playing with fire, or is this the future of medicine? We’re bypassing nature’s traditional immune response by directly programming our cells to make viral proteins. Dr. Mink Chawla and I break it all down in this episode. WATCH HERE:

Most people don’t truly understand how mRNA vaccines work. Unlike traditional vaccines, where a factory produces the antigen and injects it into the body, mRNA vaccines turn YOUR OWN CELLS into the factory. Here’s how it works: Inside every one of your cells, there are ribosomes—tiny protein-making machines. Normally, these ribosomes get instructions from your cell’s nucleus (the brain of the cell) to produce proteins that build muscle, fight infections, and keep your body functioning. mRNA vaccines hijack this natural process by delivering a blueprint that instructs your ribosomes to produce a specific protein—like the spike protein of a virus. Your immune system then recognizes this protein as foreign, triggering a defense response and preparing your body to fight off future infections. Why does this matter? 1️⃣ Faster production – No need for external manufacturing of viral proteins, cutting vaccine development time. 2️⃣ Adaptability – The technology can be rapidly adjusted for new viruses and mutations. 3️⃣ No live virus – Unlike traditional vaccines, mRNA vaccines don’t use weakened or dead viruses, reducing risk. But here’s the big question: Are we playing with fire, or is this the future of medicine? We’re bypassing nature’s traditional immune response by directly programming our cells to make viral proteins. Dr. Mink Chawla and I break it all down in this episode. WATCH HERE:

Gary Brecka

51,737 views • 1 year ago

NEW EPISODE of HARD DRUGS! AlphaFold, ProteinMPNN and other AI tools are transforming biology and drug design. But how do they work? What can’t they do (yet)? And can we use them to make a vaccine against Strep A for the very first time? In this episode, Jacob and I talk about hacking proteins with AI. 03:21 What makes proteins cool 05:29 Can we make a vaccine against Strep A? 10:12 Proteins in nature aren’t enough, and we can improve them with AI 21:12 ProteinMPNN and AlphaFold are transforming drug design 29:52 A short history of protein structure prediction from physical models to deep learning 34:48 Using AI to design a Strep A vaccine 39:27 Validating an AI-designed Strep A vaccine 43:09 Recent AI protein breakthroughs 49:30 Why we don’t already have a Strep A vaccine and the future of optimizing protein drugs

NEW EPISODE of HARD DRUGS! AlphaFold, ProteinMPNN and other AI tools are transforming biology and drug design. But how do they work? What can’t they do (yet)? And can we use them to make a vaccine against Strep A for the very first time? In this episode, Jacob and I talk about hacking proteins with AI. 03:21 What makes proteins cool 05:29 Can we make a vaccine against Strep A? 10:12 Proteins in nature aren’t enough, and we can improve them with AI 21:12 ProteinMPNN and AlphaFold are transforming drug design 29:52 A short history of protein structure prediction from physical models to deep learning 34:48 Using AI to design a Strep A vaccine 39:27 Validating an AI-designed Strep A vaccine 43:09 Recent AI protein breakthroughs 49:30 Why we don’t already have a Strep A vaccine and the future of optimizing protein drugs

Saloni

72,561 views • 8 months ago

“Proteins sticking to other proteins is what makes life exist.” 🧬 We explain the science behind AlphaProteo: our AI system for designing protein binders that holds huge potential for biology. ▶️ Hear from Jue Wang, co-lead of the protein design team, David La, research scientist, and Harshnira Patani, wet lab lead here at Google DeepMind. ↓

“Proteins sticking to other proteins is what makes life exist.” 🧬 We explain the science behind AlphaProteo: our AI system for designing protein binders that holds huge potential for biology. ▶️ Hear from Jue Wang, co-lead of the protein design team, David La, research scientist, and Harshnira Patani, wet lab lead here at Google DeepMind. ↓

Google DeepMind

67,493 views • 1 year ago