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RFdiffusion2 now available! Atomic-level scaffolding for complex active sites Available on Tamarind Bio now. RFdiffusion2 shows state-of-the-art atomic-level scaffolding that generalizes to complex, multi-island active sites, and it reliably yields active enzymes with modest screening, though activities are still below the best native enzymes and should improve with richer...

18,492 просмотров • 11 месяцев назад •via X (Twitter)

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Karpathy's Agentic Engineering finally has proper tooling! (built by Google) Karpathy defined agentic engineering as the discipline that separates production agent work from vibe coding. The core skills he listed were spec design, eval loops, and security oversight. The problem has been that practicing this still requires a different tool for every phase: - editor for code - a terminal for scaffolding - a browser for testing - a cloud console for deployment - and a separate framework for evals. Every transition is a context switch. The solution to production-grade Agentic Engineering is now actually implemented in Google’s Agents CLI. It covers the entire workflow in one place for scaffolding, evaluating, and deploying ADK agents. One setup command injects 7 ADK-specific skills into a coding agent's context, which lets it handle scaffolding, evals, deployment, and enterprise registration through natural language. I tested this end-to-end by building a RAG agent from scratch using Claude Code. It scaffolded the full project from the ADK agentic_rag template, generated 20 eval scenarios with LLM-as-judge scoring, and returned a quantitative scorecard. Finally, it also deployed everything to Agent Runtime and registered the agent to Gemini Enterprise, so the entire org can discover and use it. The video below shows this in action, and I worked with the Google Cloud team to put this together. Agents CLI GitHub repo → (don't forget to star it ⭐ ) I wrote up the full build covering all six steps from install to enterprise registration. It includes the eval scorecard, the instruction loophole the eval caught before deployment, and what the deployment process actually looks like end-to-end. Read it below.

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🚨 SCIENTISTS FINALLY FIGURED OUT WHY GOLD NEVER TARNISHES AND IT’S ALL ABOUT ATOM GEOMETRY. Gold stays perfectly shiny for centuries while silver dulls, copper turns green, and iron rusts. For decades, no one could explain exactly why. Now researchers at Tulane University have cracked it using quantum simulations. When gold is cut, its surface atoms don’t stay still. They rearrange into a stable hexagonal pattern. This specific geometry makes it extremely difficult for oxygen molecules to split and react with the metal requiring far more energy than other arrangements. Why this matters: • Gold’s famous inertness is not just chemical it’s geometric • The hexagonal “reconstruction” of atoms creates a protective barrier at the atomic level • This explains why gold is so resistant to tarnishing and corrosion • It also shows why gold is normally a poor catalyst but could become an excellent one if we force atoms into different patterns The deeper implication is enormous: We are learning that the behavior of materials at the atomic scale is controlled by geometry as much as chemistry. By understanding and controlling this atomic rearrangement, scientists could finally make gold a powerful catalyst for clean chemistry while keeping its legendary shine for jewelry and electronics. What other “eternal” properties of materials might actually come down to tiny patterns of atoms? Follow for more frontier physics and materials science.

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