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The most evidence-backed way to boost cellular NAD is with the precursor nicotinamide riboside (NR), not with oral NAD or NMN supplements Compounds with phosphate groups, like NAD and NMN, do not efficiently cross cell membranes and must be broken down before transport NR lacks that phosphate and can...

139,435 просмотров • 6 месяцев назад •via X (Twitter)

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NAD is the molecule behind energy, recovery, and aging. But most people still can’t explain what it actually does or what it means to “raise” it. In this episode, Dr. Charles Brenner (Charles Brenner, PhD), the scientist who discovered nicotinamide riboside, walks through NAD biology to explain how it's part of the “wiring” that moves energy through living systems, powering ATP production, building new tissue, and fueling repair. We dig into why NAD matters for DNA repair, how inflammation and metabolic disease put the NAD system “under attack,” and why blood NAD levels don’t always tell you what’s happening inside tissues like liver, muscle, or brain. We also discuss the real differences between NR and NMN, conditions where NAD boosting shows promise, such as inflammation, peripheral artery disease, respiratory infections, cognitive impairment, and fertility, and important safety concerns, including sourcing, product quality, and cancer. If you’ve ever wondered whether NAD boosters are legit, what they’re actually doing in the body, and how to leverage them for health and longevity, this is the episode. Dr. Charles Brenner is a true pioneer in NAD science. Links to the episode on all platforms in the comments below. Timestamps: 0:00 - Introduction 1:58 - Why disease states disrupt NAD 6:42 - How coronavirus infection affects NAD 9:55 - Inflating NAD with diet & supplements 11:49 - Why blood NAD can mislead 13:20 - Can obesity drain NAD resources? 16:01 - Does poor sleep reduce NAD? 16:53 - Anti-inflammatory effects of NR 21:38 - Can one lifestyle change fix NAD? 24:22 - NAD precursors & cognitive benefits 27:58 - Should you measure NAD levels? 30:59 - Exercise for boosting NAD 33:01 - NR for exercise recovery 35:35 - How acute sleep loss affects NAD 37:07 - NR during pregnancy 43:48 - Does NR benefit fertility? 44:58 - NAD precursors for jet lag & shift work 47:41 - Best time to take NR? 50:41 - NAD supplements vs. precursors 54:28 - NAD IV drips 55:36 - Oral vs. IV nicotinamide riboside 57:06 - Do oral NAD supplements work? 58:58 - NMN vs. NR 1:02:06 - Gut microbiome & NAD levels 1:04:44 - NR supplements & immune function 1:08:02 - NR for peripheral artery disease 1:12:26 - Can NR reduce liver fat? 1:17:33 - Recovery benefits 1:19:18 - Safe dosage for nicotinamide riboside 1:21:21 - Resveratrol & pterostilbene 1:22:57 - NAD precursors—why sourcing matters 1:25:09 - NAD supplements & cancer risk 1:30:55 - Should healthy people take NR? 1:33:43 - Charles Brenner’s NAD journey 1:38:13 - NAD’s role in energy & repair 1:45:00 - Why NAD fuels DNA repair 1:46:50 - How PARP enzymes consume NAD 1:49:29 - NAD’s role in gene regulation 1:51:49 - Why NAD shortages hit the brain hardest

Dr. Rhonda Patrick

145,717 просмотров • 6 месяцев назад