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This is how your immune system chases pathogens and destroyes them. It's called Phagocytosis: the immune response of Macrophage cells in this case directed to Escherichia coli bacteria which attach on the digestive system. [🎞️ Helix Animation]

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Massimo

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MrBeast reveals his immune system condition requires an IV treatment every eight weeks and it completely nukes his immune system "So I'm on what's called Remicade and so every eight weeks they just do an IV with a huge bag which essentially suppresses my immune system so that's why I get sick very easily." "Because the answer to my immune system attacking itself is just to f***ing nuke my immune system." Joe Rogan: "Oh Jesus Christ." MrBeast: "I know. So it's a little annoying. It's unfortunate. I'm stuck with it. What can you do."

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🧪 Back in the 1980s and early '90s, researchers started uncovering something suprising inside the aloe vera plant: a sugar molecule called acemannan. It wasn't just soothing burns or helping skin heal faster, it was communicating with the immune system. In lab tests and hospital settings, doctors noticed that aloe's compounds could help white blood cells "wake up" and respond more efficiently without overstimulation. 🦠One doctor working with HIV patients even saw immune markers improve after giving them the pure aloe extract. But as soon as the research gained traction, the story fizzled out. Funding dried up, pharmaceutical interests shifted focus, and the patents for acemannan extraction quietly got tucked away under corporate control. What had started as a promising immune discovery suddenly and conveniently disappeared. 🔒 Today, aloe is marketed mostly for skin care or digestion, but that's only a fraction of what it can do. Beneath its green skin lies a compound so unique that it was once granted "orphan drug status" by the FDA in 1995 for its role in supporting immune recovery in HIV patients. That should've been front page news but instead it was buried under the noise of pharmaceutical progress. 🌱 Interesting how this humble desert plant was quietly doing what billions of research dollars were still trying to replicate (helping the body remember how to heal itself but safely with no side effects, no contraindications and no toxicity levels.... ⭐️ Today only about 130 patents for proper extraction and stabilization exist, the most recent patent having the highest immune modulating 1,100 fractions in the world. This essentially means ideal compatibility for the body to recognize and use acemannan immediately upon taking. ❔ Think about how disruptive this could be if people actually started understanding how incredibly powerful their immune system was when it's function properly... -laurae_ramos

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Sound on 🔊 When a baby nurses, microscopic amounts of saliva flow back into the breast. That saliva carries biological signals about the infant’s immune system. If the baby is getting sick, the mother’s body detects it. Within hours, the milk changes. White blood cells surge. Macrophages multiply. Targeted antibodies appear. Miraculous, isn't it? This is why mother's milk is so critical. It's not just the bonding, or the colostrum. Or that it's exceptionally high in immunoglobulins, white blood cells, proteins and essential vitamins, serving as a crucial "natural vaccination" that protects the newborn's immature digestive system and boosts immunity. It can actually make sick babies well. We, with all our scientific know-how, can't do this. So it's critical that babies and mum stay together. Under the shed is this century's hedgerow. We've destroyed the hedgehog's natural habitat so these clever, adaptable little animals, these survival specialists, have learnt to use our spaces. Under a shed the temperature stays more or less constant. It's dry, protected, inaccessible to predators, and completely undisturbed. The perfect nesting spot. Right now, these spaces are being used by hibernating hedgehogs. And from the end of April they will start being used by mums and their newborns. So if you are planning on removing or replacing an old shed this year PLEASE, I beg you, remember this is a precious space. Plan your renovations in the small relatively safe windows of the first 3 weeks of April, or the month of September. This kind consideration on your part will help these gentle, endangered animals to thrive, and produce a strong and healthy new generation.

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Inside every cell, there is a transport system that determines how materials move, signals propagate, and structure is maintained. This video captures that system in motion. The glowing streaks mark the growing ends of microtubules (protein polymers that constantly assemble and disassemble through a process called dynamic instability). Rather than forming permanent tracks, microtubules are rebuilt continuously, allowing cells to reorganize their internal layout in real time. This behavior is essential for life. Cells rely on microtubule dynamics to divide accurately, migrate during development and repair, and maintain long-distance transport in neurons that may span over a meter in length. When this system is altered, the consequences are significant. Certain cancer therapies work by locking microtubules in place, preventing cell division. In contrast, failures in microtubule transport are linked to neurodegenerative conditions (like Alzheimer's) where intracellular delivery breaks down. What appears as abstract motion under a microscope is actually one of the core systems that keeps cells functional, adaptable, and alive. Video Credit: Andy Moore

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If we want healthier kids with fewer allergies, we have to allow more of this. Yes it is messy. But connecting with nature, natural light, space to explore and down regulate the nervous system, ingesting microbes from the earth are critically important to building strong, resilient, regulated immune systems.

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🦠Harness the natural healing properties of common kitchen ingredients with this simple, effective remedy. There are many benefits to these herbs, here are some of these herbs can help: 🌿Thyme: Contains thymol, a compound with antimicrobial properties, aiding in respiratory health. 🌿Sage: Is Antimicrobial Which Helps fight bacteria, viruses, and fungi. 🧄Garlic: Rich in allicin, known for its antibacterial and antiviral effects. 🫚Ginger: Offers anti-inflammatory benefits and supports digestion. 🧅Onion: Provides antioxidants that boost the immune system. 🍯 Honey- Acts as a natural cough suppressant and soothes throat irritation. ✨Recipe✨ 1. Boil a handful of fresh thyme & Sage in 2 cups of water for 10 minutes. 2. Meanwhile, finely chop 1 small onion, 3 cloves of garlic, and a 1-inch piece of ginger; place them in a mason jar. 3. Add 2 tablespoons of raw honey to the jar. 4. Strain the thyme-infused water into the jar, mixing well. How to Use It: Preventative: Take 1 tablespoon daily to boost your immune system. During illness: Take 3-4 tablespoons daily to fight off symptoms naturally.
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🦠Harness the natural healing properties of common kitchen ingredients with this simple, effective remedy. There are many benefits to these herbs, here are some of these herbs can help: 🌿Thyme: Contains thymol, a compound with antimicrobial properties, aiding in respiratory health. 🌿Sage: Is Antimicrobial Which Helps fight bacteria, viruses, and fungi. 🧄Garlic: Rich in allicin, known for its antibacterial and antiviral effects. 🫚Ginger: Offers anti-inflammatory benefits and supports digestion. 🧅Onion: Provides antioxidants that boost the immune system. 🍯 Honey- Acts as a natural cough suppressant and soothes throat irritation. ✨Recipe✨ 1. Boil a handful of fresh thyme & Sage in 2 cups of water for 10 minutes. 2. Meanwhile, finely chop 1 small onion, 3 cloves of garlic, and a 1-inch piece of ginger; place them in a mason jar. 3. Add 2 tablespoons of raw honey to the jar. 4. Strain the thyme-infused water into the jar, mixing well. How to Use It: Preventative: Take 1 tablespoon daily to boost your immune system. During illness: Take 3-4 tablespoons daily to fight off symptoms naturally.

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“Raising your frequency” is actually rooted in science. 🤓👇🏻 Everything is energy, connected through electromagnetic vibrational frequencies. Atoms, emotions, thoughts, viruses, and bacteria all operate at specific frequencies. When our frequency drops due to physiological, emotional, or environmental factors, our immune system weakens, making it easier for pathogens to thrive. 🔋Even Tesla noted that eliminating harmful external frequencies could boost disease resistance. Do we NEED to stand in a singing bowl and sing kumbaya? No, but a good start is to #GTFOutside. #singingbowl #frequency #energy

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The more I see this clip, the more I feel embarrassed of the system I work and live in. This is not a smile, this is a straight laughing at the face of system's so called justice.
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The more I see this clip, the more I feel embarrassed of the system I work and live in. This is not a smile, this is a straight laughing at the face of system's so called justice.

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What are you waiting for? #GTFOustside and get it done! The diving board of life awaits your gracefulness 😂 But for real... This is a reminder to #GFTOutside today. Whether it be for a run, a workout or an Olympic-style cool off, just do it. 😜 & In case you need more reasons… Vitamin D is CRUCIAL for calcium absorption, bone health, and supporting the immune system. Sun exposure stimulates the production of serotonin, a neurotransmitter associated with feelings of well-being and happiness! See you in the pool 😎

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A single E. coli cell, placed on a dish, will become 70 billion cells in just 12 hours. That’s exponential growth. But a new preprint shows that it's possible to engineer E. coli to grow linearly instead, where only one daughter cell continues dividing and the other stops. First, some context. In nature, there is a bacterium called Mycobacterium smegmatis (initially discovered in 1884 in ulcers scraped from syphilis patients.) M. smegmatis is weird because it divides asymmetrically. These cells grow only from one end, and all their cell wall biosynthesis machinery is located on that one end. So when the cell divides, one daughter gets this machinery and the other gets nothing. The daughter that gets the machinery can keep dividing immediately, but the other daughter has to remake all that machinery from scratch, so its growth is delayed. E. coli doesn’t grow like this. When it divides, it pinches in the middle and splits everything evenly. Enzymes, metabolites, and proteins get partitioned more or less randomly between the two daughters. For the new preprint, though, researchers engineered E. coli to behave more like M. smegmatis. Here is how they did it: First, they deleted a gene called cyaA, which encodes an enzyme (adenylate cyclase) that makes a molecule called cAMP. cAMP is SUPER IMPORTANT! It is a nutrient sensor that instructs E. coli to switch on genes that help it digest non-glucose carbon sources when glucose is scarce. Without cAMP, E. coli cells growing on alternative carbon sources will starve; they won’t know how to eat the food. Next, they added back a “split” version of the cyaA gene into the cells. In other words, they split the gene in two so that each half of the enzyme is made separately. Cells can only make cAMP, and thus eat non-glucose carbon sources, if these two halves come together. To facilitate that “coming together,” the researchers also fused the split cyaA proteins to sticky proteins that clump together, and to a fluorescent protein (to make it easy to track these molecules in the cell.) So now some interesting things start to happen if you grow E. coli on a growth medium lacking glucose. As the cell grows, its cyaA “halves” start clumping together into a giant ball. Inside the aggregate, the two enzyme halves come together and make cAMP. And when the cell gets big enough and divides, the clump of cyaA RANDOMLY goes to either daughter cell #1 or #2. The daughter that gets the aggregate (called PA+ in this paper) can keep dividing. The daughter that doesn’t (PA–) cannot. It still grows a few times — about four divisions — because it inherits some leftover cAMP from its mother. But after that, the metabolite is diluted away, and the cell stops growing. PA+ cells went through about 23 divisions on average before their aggregate decayed. And the population of cells, as a whole, grew linearly. This paper is cool because there are many applications where exponential growth is too unpredictable and, perhaps, unsafe. If you want to engineer bacteria to deliver drugs, clean up waste, or live in the gut, you don’t want them to double uncontrollably. This paper shows you can make them expand in a controlled, linear way. Alas, mutations could break this whole engineered system. A mutation that restores cyaA, for example, would give cells a new way to make cAMP. Mutations that make the aggregates split between daughters would break the asymmetry, too. But still, I really enjoy proof-of-concept engineering papers like this.
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A single E. coli cell, placed on a dish, will become 70 billion cells in just 12 hours. That’s exponential growth. But a new preprint shows that it's possible to engineer E. coli to grow linearly instead, where only one daughter cell continues dividing and the other stops. First, some context. In nature, there is a bacterium called Mycobacterium smegmatis (initially discovered in 1884 in ulcers scraped from syphilis patients.) M. smegmatis is weird because it divides asymmetrically. These cells grow only from one end, and all their cell wall biosynthesis machinery is located on that one end. So when the cell divides, one daughter gets this machinery and the other gets nothing. The daughter that gets the machinery can keep dividing immediately, but the other daughter has to remake all that machinery from scratch, so its growth is delayed. E. coli doesn’t grow like this. When it divides, it pinches in the middle and splits everything evenly. Enzymes, metabolites, and proteins get partitioned more or less randomly between the two daughters. For the new preprint, though, researchers engineered E. coli to behave more like M. smegmatis. Here is how they did it: First, they deleted a gene called cyaA, which encodes an enzyme (adenylate cyclase) that makes a molecule called cAMP. cAMP is SUPER IMPORTANT! It is a nutrient sensor that instructs E. coli to switch on genes that help it digest non-glucose carbon sources when glucose is scarce. Without cAMP, E. coli cells growing on alternative carbon sources will starve; they won’t know how to eat the food. Next, they added back a “split” version of the cyaA gene into the cells. In other words, they split the gene in two so that each half of the enzyme is made separately. Cells can only make cAMP, and thus eat non-glucose carbon sources, if these two halves come together. To facilitate that “coming together,” the researchers also fused the split cyaA proteins to sticky proteins that clump together, and to a fluorescent protein (to make it easy to track these molecules in the cell.) So now some interesting things start to happen if you grow E. coli on a growth medium lacking glucose. As the cell grows, its cyaA “halves” start clumping together into a giant ball. Inside the aggregate, the two enzyme halves come together and make cAMP. And when the cell gets big enough and divides, the clump of cyaA RANDOMLY goes to either daughter cell #1 or #2. The daughter that gets the aggregate (called PA+ in this paper) can keep dividing. The daughter that doesn’t (PA–) cannot. It still grows a few times — about four divisions — because it inherits some leftover cAMP from its mother. But after that, the metabolite is diluted away, and the cell stops growing. PA+ cells went through about 23 divisions on average before their aggregate decayed. And the population of cells, as a whole, grew linearly. This paper is cool because there are many applications where exponential growth is too unpredictable and, perhaps, unsafe. If you want to engineer bacteria to deliver drugs, clean up waste, or live in the gut, you don’t want them to double uncontrollably. This paper shows you can make them expand in a controlled, linear way. Alas, mutations could break this whole engineered system. A mutation that restores cyaA, for example, would give cells a new way to make cAMP. Mutations that make the aggregates split between daughters would break the asymmetry, too. But still, I really enjoy proof-of-concept engineering papers like this.

Niko McCarty.

58,041 Aufrufe • vor 11 Monaten

There's a bacteriophage that turns bacteria into “liquid crystals.” Specifically, Pseudomonas aeruginosa bacteria make Pf phages, which are rod-shaped, negatively-charged, and measure about 2 micrometers in length (roughly the length of an E. coli cell). These phages leave the cells and enter their surroundings. There, they mix with polymers, also secreted by the cells, to form a crystalline matrix. Surprisingly, this is good for the cells. Although the phages kill some of them, it also makes their biofilms stickier and able to withstand certain antibiotics. These bacteria + phages are prevalent in cystic fibrosis patients; they've formed a sort of symbiotic relationship. The Pf phages are made from thousands of repeating copies of a coat protein, called CoaB, which wraps around a single-stranded, circular DNA genome. These genes are integrated directly on the bacterial chromosome. The bacteria “turn on” these phage genes when placed in a viscous environment with low oxygen levels. This is like a trigger to start forming a biofilm. And the cells make a lot of phages; about 100 billion per milliliter. These liquid crystals form because of a physics principle called “depletion attraction.” If you just mix a bunch of loose or flexible polymers together (such as long carbon chains) they will not form a liquid crystal. But if you mix stiff rods (the phages) with loose polymers at a high enough concentration, the polymers will force the phages close together to create a material that flows like a liquid despite being ordered like a crystal. See the video below. These liquid crystal biofilms are hard to get rid of. The negatively-charged phages block many antibiotics (like aminoglycosides, which are positively-charged) from entering cells. Liquid crystals also retain water, so these biofilms can survive on drier surfaces. I first heard about this from Malmesbury’s excellent newsletter, called “Telescopic Turnip.”
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There's a bacteriophage that turns bacteria into “liquid crystals.” Specifically, Pseudomonas aeruginosa bacteria make Pf phages, which are rod-shaped, negatively-charged, and measure about 2 micrometers in length (roughly the length of an E. coli cell). These phages leave the cells and enter their surroundings. There, they mix with polymers, also secreted by the cells, to form a crystalline matrix. Surprisingly, this is good for the cells. Although the phages kill some of them, it also makes their biofilms stickier and able to withstand certain antibiotics. These bacteria + phages are prevalent in cystic fibrosis patients; they've formed a sort of symbiotic relationship. The Pf phages are made from thousands of repeating copies of a coat protein, called CoaB, which wraps around a single-stranded, circular DNA genome. These genes are integrated directly on the bacterial chromosome. The bacteria “turn on” these phage genes when placed in a viscous environment with low oxygen levels. This is like a trigger to start forming a biofilm. And the cells make a lot of phages; about 100 billion per milliliter. These liquid crystals form because of a physics principle called “depletion attraction.” If you just mix a bunch of loose or flexible polymers together (such as long carbon chains) they will not form a liquid crystal. But if you mix stiff rods (the phages) with loose polymers at a high enough concentration, the polymers will force the phages close together to create a material that flows like a liquid despite being ordered like a crystal. See the video below. These liquid crystal biofilms are hard to get rid of. The negatively-charged phages block many antibiotics (like aminoglycosides, which are positively-charged) from entering cells. Liquid crystals also retain water, so these biofilms can survive on drier surfaces. I first heard about this from Malmesbury’s excellent newsletter, called “Telescopic Turnip.”

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50,082 Aufrufe • vor 7 Monaten