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Today we are sharing our most complex #assembloid to date: a 4-part model of the human ascending neural somatosensory pathway generated by functionally integrating stem cell-derived cerebral cortical, thalamic, spinal and sensory #organoids. Check out the bioRxiv and a short video of activity as these parts self-assemble Work led... show more

Sergiu P. Pasca

14,454 subscribers

39,733 次观看 • 2 年前 •via X (Twitter)

教育健康养生科学技术 #assembloid #organoids

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Cells located in the midline of the embryo play crucial roles in development. These cells often influence cell fate decisions and guide axons to establish bilateral connections. Despite their importance, studying these transient cells and their complex interactions has been challenging. Today, we introduce human midline #assembloids—3D self-organizing cellular clusters derived from stem cells by the functional integration of floor plate #organoids and spinal cord #organoids. We demonstrate that midline assembloids enable cell specification and axon guidance in human neurons. Additionally, we use these assembloids to screen and identify human-enriched factors that control these processes. Work led by the incredible Massimo Onesto & Neal Amin!! More details in the preprint 👇

Cells located in the midline of the embryo play crucial roles in development. These cells often influence cell fate decisions and guide axons to establish bilateral connections. Despite their importance, studying these transient cells and their complex interactions has been challenging. Today, we introduce human midline #assembloids—3D self-organizing cellular clusters derived from stem cells by the functional integration of floor plate #organoids and spinal cord #organoids. We demonstrate that midline assembloids enable cell specification and axon guidance in human neurons. Additionally, we use these assembloids to screen and identify human-enriched factors that control these processes. Work led by the incredible Massimo Onesto & Neal Amin!! More details in the preprint 👇

Sergiu P. Pasca

15,818 次观看 • 2 年前

🚀 Excited to share our #ICLR2025 work on planning with neural dynamics models! While our lab has developed diverse neural dynamics models for manipulating rigid, deformable, and granular objects, having the model alone doesn’t solve the problem—planning with it remains a challenge. 💡 Enter BaB-ND, led by Keyi and Jiangwei! We propose a scalable, GPU-accelerated branch-and-bound algorithm, inspired by neural network verification, to enable effective planning for diverse objects modeled with neural dynamics. 🔗 Project page (open-source + detailed docs!): 🎥 Watch the video to see T being pushed around obstacles, and check out Keyi’s thread for more details!

🚀 Excited to share our #ICLR2025 work on planning with neural dynamics models! While our lab has developed diverse neural dynamics models for manipulating rigid, deformable, and granular objects, having the model alone doesn’t solve the problem—planning with it remains a challenge. 💡 Enter BaB-ND, led by Keyi and Jiangwei! We propose a scalable, GPU-accelerated branch-and-bound algorithm, inspired by neural network verification, to enable effective planning for diverse objects modeled with neural dynamics. 🔗 Project page (open-source + detailed docs!): 🎥 Watch the video to see T being pushed around obstacles, and check out Keyi’s thread for more details!

Yunzhu Li

10,561 次观看 • 1 年前

Today, we are releasing Stable Video Diffusion, our first foundation model for generative AI video based on the image model, Stable Diffusion. As part of this research preview, the code, weights, and research paper are now available. Additionally, today you can sign up for our waitlist to access a new upcoming web experience featuring a Text-To-Video interface. To access the model & sign up for our waitlist, visit our website here:

Today, we are releasing Stable Video Diffusion, our first foundation model for generative AI video based on the image model, Stable Diffusion. As part of this research preview, the code, weights, and research paper are now available. Additionally, today you can sign up for our waitlist to access a new upcoming web experience featuring a Text-To-Video interface. To access the model & sign up for our waitlist, visit our website here:

Stability AI

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With health and good fortune, an elephant can walk the earth up to 70 years. As we nurture the orphans of today, we must think even bigger — safeguarding their future and ensuring that elephants always have a place on our planet. With #WorldElephantDay (August 12) just a week away, we will spend the coming days reflecting on the many ways we are working to secure the future of Kenya’s elephants — highlighting the everyday heroes and field conservation work made possible by donors like you. Learn more our work and become part of our story as a SWT donor or adopter: #everystepmatters

With health and good fortune, an elephant can walk the earth up to 70 years. As we nurture the orphans of today, we must think even bigger — safeguarding their future and ensuring that elephants always have a place on our planet. With #WorldElephantDay (August 12) just a week away, we will spend the coming days reflecting on the many ways we are working to secure the future of Kenya’s elephants — highlighting the everyday heroes and field conservation work made possible by donors like you. Learn more our work and become part of our story as a SWT donor or adopter: #everystepmatters

Sheldrick Wildlife Trust

24,879 次观看 • 1 年前

In our work just published in Journal of Fluid Mechanics, we show a new mode of shedding in the wake of a cylinder forced to oscillate in viscoelastic flow, that is caused entirely by fluid's viscoelasticity. These are the elongated red and blue regions in the video.

In our work just published in Journal of Fluid Mechanics, we show a new mode of shedding in the wake of a cylinder forced to oscillate in viscoelastic flow, that is caused entirely by fluid's viscoelasticity. These are the elongated red and blue regions in the video.

Yahya Modarres-Sadeghi

11,964 次观看 • 2 年前

Break-A-Scene: Extracting Multiple Concepts from a Single Image introduce the task of textual scene decomposition: given a single image of a scene that may contain several concepts, we aim to extract a distinct text token for each concept, enabling fine-grained control over the generated scenes. To this end, we propose augmenting the input image with masks that indicate the presence of target concepts. These masks can be provided by the user or generated automatically by a pre-trained segmentation model. We then present a novel two-phase customization process that optimizes a set of dedicated textual embeddings (handles), as well as the model weights, striking a delicate balance between accurately capturing the concepts and avoiding overfitting. We employ a masked diffusion loss to enable handles to generate their assigned concepts, complemented by a novel loss on cross-attention maps to prevent entanglement. We also introduce union-sampling, a training strategy aimed to improve the ability of combining multiple concepts in generated images. We use several automatic metrics to quantitatively compare our method against several baselines, and further affirm the results using a user study. Finally, we showcase several applications of our method paper page:

Break-A-Scene: Extracting Multiple Concepts from a Single Image introduce the task of textual scene decomposition: given a single image of a scene that may contain several concepts, we aim to extract a distinct text token for each concept, enabling fine-grained control over the generated scenes. To this end, we propose augmenting the input image with masks that indicate the presence of target concepts. These masks can be provided by the user or generated automatically by a pre-trained segmentation model. We then present a novel two-phase customization process that optimizes a set of dedicated textual embeddings (handles), as well as the model weights, striking a delicate balance between accurately capturing the concepts and avoiding overfitting. We employ a masked diffusion loss to enable handles to generate their assigned concepts, complemented by a novel loss on cross-attention maps to prevent entanglement. We also introduce union-sampling, a training strategy aimed to improve the ability of combining multiple concepts in generated images. We use several automatic metrics to quantitatively compare our method against several baselines, and further affirm the results using a user study. Finally, we showcase several applications of our method paper page:

AK

154,511 次观看 • 3 年前

Gemma 4 is here! Our most intelligent open models to date, are built on the same world-class research and tech as Gemini 3, and are sized to run and fine-tune efficiently on local hardware. Check out what Google Gemma 4 brings to devs: 💎 Advanced Reasoning: Deep logic tasks, complex multi-step planning, and beyond 💎 Longer context: Seamlessly analyze entire codebases with context windows of 128K tokens for our edge models and 256K tokens for our largest models 💎 Vision and audio: Rich, multimodal interactions out of the box 💎 140+ languages: Trained on 140+ languages 💎 Apache 2.0 license: industry-standard open-source license

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Google for Developers

269,912 次观看 • 4 个月前

At $HASHAI, we are committed to both delivering against our strategic and operational goals as well as providing transparency to enable trust for new and existing investors alike. We are delighted to show you a short video that demonstrates and verifies our new infrastructure, which is part of our $3 million international expansion. In this video, you will see one of our international sites, which has the benefits of gas and water cooling jackets. Our S19-XP’s are installed and running, currently being stress tested with our #AI algorithms, and a "go-live" date will be communicated within the next week. The whole team will be visiting this site very soon, and further videos will be posted for our community every step of the way.

At $HASHAI, we are committed to both delivering against our strategic and operational goals as well as providing transparency to enable trust for new and existing investors alike. We are delighted to show you a short video that demonstrates and verifies our new infrastructure, which is part of our $3 million international expansion. In this video, you will see one of our international sites, which has the benefits of gas and water cooling jackets. Our S19-XP’s are installed and running, currently being stress tested with our #AI algorithms, and a "go-live" date will be communicated within the next week. The whole team will be visiting this site very soon, and further videos will be posted for our community every step of the way.

Hash AI

247,470 次观看 • 2 年前

What is an individual? Can we accept the idea that an individual is not an isolated being, but a totality of traits, ideas, and deeds that arise within humanity, are shaped by it, and return to it? Every human being is a temporary form through which humanity expresses a part of itself. : The author redefines the individual not as an isolated entity but as a transient expression of humanity itself: a unique constellation of traits, ideas, and deeds that emerge from the collective, are molded by it, and ultimately return to enrich it. Each person serves as a temporary vessel through which humanity manifests and explores its own nature. This dissolves the illusion of absolute separateness, revealing every life as an integral thread in the living fabric of humankind. It portrays individuality as both gift and responsibility: a fleeting opportunity to contribute distinct value to the whole. The concept elevates personal existence to a sacred role in humanity’s continuous self-creation. It leads to recognition that our thoughts, actions, and choices ripple beyond the self, shaping the shared human story. Ultimately, framing every individual as both creation and co-creator of humanity’s evolving essence, bound in profound interdependence.

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Zafar Mirzo | Quotes

864,277 次观看 • 8 个月前

Congratulations Warhorse Studios on the release of Kingdom Come: Deliverance II! Fun fact: In 2016 we recorded our own version of “Kingdom Come” by Manowar, and a few months later, once the brilliant Kingdom Come: Deliverance II was released into the world of gaming, we found our cover perfectly complemented the game. Because of this, we decided to release a video featuring some awesome footage from the game. We honour this special day today by watching it! Check it out 👉

Congratulations Warhorse Studios on the release of Kingdom Come: Deliverance II! Fun fact: In 2016 we recorded our own version of “Kingdom Come” by Manowar, and a few months later, once the brilliant Kingdom Come: Deliverance II was released into the world of gaming, we found our cover perfectly complemented the game. Because of this, we decided to release a video featuring some awesome footage from the game. We honour this special day today by watching it! Check it out 👉

Sabaton

20,294 次观看 • 1 年前

Most of you know the work we do in GBV, we also do work in women empowerment. The two work in tandem. You know if you invite me to a conference, I stay behind and collect unused pens and notebooks for further use. I mean reduce, reuse and recycle. Lol. But most importantly I pick what we can use for our EMPAWA Mama program on Saturdays. I ask women who can share their skills to come to Soweto and speak to usm This Saturday we celebrated IWD and we did what we do best. Our Chama women met and were trained by one of the best Chama trainers CHAMA Champions who visited and gave great insights on how we can continue to grow VW Babes came to Soweto to participate and support our work and heh we have never seen these many VWs. The ladies stayed and also built our capacity We had a partnership with chiraz International at Jacaranda Hotel as usual we went with our Soweto mamas and there were topics like burnout, toxic relationships led by our own psychologist Njoki Maina. We also learnt first aid and self defense. And Separ will be coming to Soweto to train our ladies in first aid as well as self defense. That is how we Accelerate Action #Usikimye

Most of you know the work we do in GBV, we also do work in women empowerment. The two work in tandem. You know if you invite me to a conference, I stay behind and collect unused pens and notebooks for further use. I mean reduce, reuse and recycle. Lol. But most importantly I pick what we can use for our EMPAWA Mama program on Saturdays. I ask women who can share their skills to come to Soweto and speak to usm This Saturday we celebrated IWD and we did what we do best. Our Chama women met and were trained by one of the best Chama trainers CHAMA Champions who visited and gave great insights on how we can continue to grow VW Babes came to Soweto to participate and support our work and heh we have never seen these many VWs. The ladies stayed and also built our capacity We had a partnership with chiraz International at Jacaranda Hotel as usual we went with our Soweto mamas and there were topics like burnout, toxic relationships led by our own psychologist Njoki Maina. We also learnt first aid and self defense. And Separ will be coming to Soweto to train our ladies in first aid as well as self defense. That is how we Accelerate Action #Usikimye

Njeri Wa Migwi™

16,218 次观看 • 1 年前

Homa is excited to announce that Valentine is now a playable character in Aquarium Land, one of our most popular games. Creating a successful IP is challenging, as it requires gaining mass-market attention. This involves hundreds of millions of people acknowledging a character, following its journey, and becoming part of its community. To achieve this, Homa is investing significant resources in promoting Valentine through comics, illustrations, animations, stories, and games. By integrating Valentine into Aquarium Land, we take the first step in bridging awareness between Web2 and Web3. We aim to onboard millions of users to take part in Valentine's journey, play as her, build an emotional connection with the character, and read her stories. Aquarium Land has been downloaded more than 25 million times worldwide and has over 300,000 daily active players. As a Homa Holder, you are part of our ambitious vision: making Valentine a character that will make history by becoming part of the culture. Join us on our journey to go beyond Web3 and onboard millions of players and fans across the globe.

Homa is excited to announce that Valentine is now a playable character in Aquarium Land, one of our most popular games. Creating a successful IP is challenging, as it requires gaining mass-market attention. This involves hundreds of millions of people acknowledging a character, following its journey, and becoming part of its community. To achieve this, Homa is investing significant resources in promoting Valentine through comics, illustrations, animations, stories, and games. By integrating Valentine into Aquarium Land, we take the first step in bridging awareness between Web2 and Web3. We aim to onboard millions of users to take part in Valentine's journey, play as her, build an emotional connection with the character, and read her stories. Aquarium Land has been downloaded more than 25 million times worldwide and has over 300,000 daily active players. As a Homa Holder, you are part of our ambitious vision: making Valentine a character that will make history by becoming part of the culture. Join us on our journey to go beyond Web3 and onboard millions of players and fans across the globe.

homa

19,927 次观看 • 3 年前

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#JMPD is on the ground to tackle grime and crime in the Johannesburg Inner City! We are partnering with City departments like Pikitup to clean up our streets and ensure by-law enforcement. 🤝 This is part of our continuous effort to revitalise the city and make it safe for all residents and businesses. We appreciate the community's support and cooperation as we work towards a cleaner and safer Joburg. #NomakanjaniManjeNamhlanje #JoburgByLaws #SaferJoburg

Jo'burg Metro Police Department - JMPD

31,554 次观看 • 11 个月前

These are altar girls led by Fr. Carlos Figueiredo from Our Lady of Aparecida Church, Tapejara, State of Paraná, Brazil. The video reminds us that women should NOT: • Serve the Mass • Dance in church, especially before the altar • Have such a light and playful attitude in a sacred place where the Sacrifice of Calvary will be renewed. Most importantly: they should NOT be taught to do so by the priest. More:

These are altar girls led by Fr. Carlos Figueiredo from Our Lady of Aparecida Church, Tapejara, State of Paraná, Brazil. The video reminds us that women should NOT: • Serve the Mass • Dance in church, especially before the altar • Have such a light and playful attitude in a sacred place where the Sacrifice of Calvary will be renewed. Most importantly: they should NOT be taught to do so by the priest. More:

Tradition in Action

50,939 次观看 • 5 个月前

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“Gifts” from our Czech friends to the russians — delivered🫡 4 tanks, an unmanned ground vehicle, a buggy, and a van were destroyed by drones purchased with the support of the Czech organization Dárek pro Putina — and these are just the first results of our cooperation. Most importantly, many russians became “good” ones — because there’s no escaping a fiber-optic drone😉 We sincerely thank our Czech friends for their support. These drones continue to effectively eliminate the enemy on the hottest sections of the frontline. More to come🤝

Спільнота Стерненка

42,690 次观看 • 6 个月前

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Artificial embryo samples aboard Tiangong Space Station for life science research Space "artificial embryo" samples and other life science experiments delivered by the Tianzhou-10 cargo spacecraft have been installed into experiment modules aboard China's Tiangong space station, the Technology and Engineering Center for Space Utilization under the Chinese Academy of Sciences (CAS) said on Wednesday. The "artificial embryos" are stem cell-derived artificial human embryos. The embryos, though not true life forms and unable to develop into human babies, will help simulate the earliest stages of human development. Once the experiments are completed, the artificial embryo samples will be frozen in orbit and then returned to Earth on a future mission for side-by-side analysis with ground-based controls in laboratories on the ground. This effort is part of a broader suite of 41 space science experiments being deployed aboard Tiangong, supporting its latest round of research on the orbiting laboratory.

KABClub

23,478 次观看 • 3 个月前

We are extremely proud of this achievement that we have accomplished together. We truly risked our lives to reach this place, as it is located very close to military deployment areas, and the road was extremely dangerous at every moment. We have now started our new project to provide clean drinking water, and this truck is heading to one of the most dangerous and heavily affected areas. The work is exhausting and extremely tiring, but the need for clean water cannot wait. Displaced families are facing a severe shortage of safe drinking water, and more people are relying on this support every day. Today, we are launching water truck number 11 as part of this project, continuing despite all challenges and risks. Please share this post and follow our organization’s account to support the continuation of this life-saving work.

We are extremely proud of this achievement that we have accomplished together. We truly risked our lives to reach this place, as it is located very close to military deployment areas, and the road was extremely dangerous at every moment. We have now started our new project to provide clean drinking water, and this truck is heading to one of the most dangerous and heavily affected areas. The work is exhausting and extremely tiring, but the need for clean water cannot wait. Displaced families are facing a severe shortage of safe drinking water, and more people are relying on this support every day. Today, we are launching water truck number 11 as part of this project, continuing despite all challenges and risks. Please share this post and follow our organization’s account to support the continuation of this life-saving work.

Tamer Nahed

435,812 次观看 • 1 个月前

As per the internal assessment of Pakistani security forces, the attack was carried out by 7–8 terrorists in #Karachi With 3 neutralised, 4–5 attackers are believed to still be engaged in the firefight, and a joint security operation is currently underway. Meanwhile the Askrandu Brigade of ISPR led by Col. Shehzad Raza has released a staged propaganda video in an apparent attempt to deflect attention from the security lapses exposed by the attack.

As per the internal assessment of Pakistani security forces, the attack was carried out by 7–8 terrorists in #Karachi With 3 neutralised, 4–5 attackers are believed to still be engaged in the firefight, and a joint security operation is currently underway. Meanwhile the Askrandu Brigade of ISPR led by Col. Shehzad Raza has released a staged propaganda video in an apparent attempt to deflect attention from the security lapses exposed by the attack.

Shivank Mishra

47,872 次观看 • 1 个月前

Today, we’re sharing the history of Foundation Labs, written from our perspective as founders. What we thought, what we set out to build, and what we learned from six years on the frontier of crypto, culture, commerce, and art. We’re publishing this now while the experience is still fresh. It was important to us that a clear record exists in our own voice, rather than leaving our story to be interpreted by others over time. Our aim is to contribute to the commons. We believe there are many future chapters still to be written with this technology, and we want future founders to be able to reference and build on our experience—to start on second base. We’ll keep this online as a resource for the foreseeable future. To the artists, collectors, investors, and former teammates—thank you for being part of the journey.

Today, we’re sharing the history of Foundation Labs, written from our perspective as founders. What we thought, what we set out to build, and what we learned from six years on the frontier of crypto, culture, commerce, and art. We’re publishing this now while the experience is still fresh. It was important to us that a clear record exists in our own voice, rather than leaving our story to be interpreted by others over time. Our aim is to contribute to the commons. We believe there are many future chapters still to be written with this technology, and we want future founders to be able to reference and build on our experience—to start on second base. We’ll keep this online as a resource for the foreseeable future. To the artists, collectors, investors, and former teammates—thank you for being part of the journey.

kayvon

31,329 次观看 • 5 个月前