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Today we introduce human neural loop #assembloids created from 4 parts derived from stem cells to study the cortico-striato-midbrain-thalamo-cortical pathway and to model neurodevelopmental disease Work led by the remarkable Ji-Il Kim and Yuki Miura in the lab. Also in collaboration with the Marius Pachitariu lab at HHMI |...

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Sergiu P. Pasca

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27,406 görüntüleme • 1 yıl önce •via X (Twitter)

Sağlık & İyilikBilim & Teknoloji#assembloids
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Sergiu P. Pasca profil fotoğrafı
Sergiu P. Pasca1 yıl önce

Preprint here:

Prof Peter Hotez MD PhD profil fotoğrafı
Prof Peter Hotez MD PhD1 yıl önce

Extraordinary work, really impressive!

Sergiu P. Pasca profil fotoğrafı
Sergiu P. Pasca1 yıl önce

Thank you, Peter!

Maria Robles profil fotoğrafı
Maria Robles1 yıl önce

This is incredible. Congratulations ...the implications here are mindblowing !

Maria Robles profil fotoğrafı
Maria Robles1 yıl önce

We at Robles BioCeutics are big fans of your work !

Carolyn Bertozzi profil fotoğrafı
Carolyn Bertozzi1 yıl önce

Amazing ! 🤯

Sergiu P. Pasca profil fotoğrafı
Sergiu P. Pasca1 yıl önce

Thank you 🙏

Ella Marushchenko profil fotoğrafı
Ella Marushchenko1 yıl önce

Impressive work! Congratulations, Prof. Pasca!

Sergiu P. Pasca profil fotoğrafı
Sergiu P. Pasca1 yıl önce

Thank you

Julio Aguado profil fotoğrafı
Julio Aguado1 yıl önce

wow, exciting work indeed! 🤯

Benzer Videolar

There are now hundreds of genes associated with autism & neurodevelopmental disorders but what key processes in brain development they each disrupt remains unknown. In an article in nature today, we start tackling this question by combining forebrain #assembloids with CRISPR screens to map >400 disease genes onto stages of human cortical interneuron development. Using engineered lines, regionalized neural #organoids and over 1,000 #assembloids, we discovered a group of disease genes that interfere with GABAergic neuron generation or migration, including some surprising disease mechanisms. Check out the video below for details. This work was led by the fearless Xiangling Meng in the lab!! In collaboration with Bassik lab & Georgia Panagiotakos lab! Article here: Supported by the Stanford Brain Organogenesis Center Wu Tsai Neurosciences Institute Stanford Bio-X New York Stem Cell Foundation Research Institute Biohub
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There are now hundreds of genes associated with autism & neurodevelopmental disorders but what key processes in brain development they each disrupt remains unknown. In an article in nature today, we start tackling this question by combining forebrain #assembloids with CRISPR screens to map >400 disease genes onto stages of human cortical interneuron development. Using engineered lines, regionalized neural #organoids and over 1,000 #assembloids, we discovered a group of disease genes that interfere with GABAergic neuron generation or migration, including some surprising disease mechanisms. Check out the video below for details. This work was led by the fearless Xiangling Meng in the lab!! In collaboration with Bassik lab & Georgia Panagiotakos lab! Article here: Supported by the Stanford Brain Organogenesis Center Wu Tsai Neurosciences Institute Stanford Bio-X New York Stem Cell Foundation Research Institute Biohub

Sergiu P. Pasca

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Our latest work is out today in Science Magazine: a self-organizing system that models organizer-driven patterning and commissural axon guidance in human neural development. This was achieved with human midline #assembloids by combining floor plate and spinal cord #organoids from pluripotent stem cells. A key advance is the three-part configuration (a floor plate squeezed in between two spinal cords), which enables human axons to cross the midline (and the subsequent synchronization of activity between the two parts seen in the video below). This platform opens the door to many applications; here, we used it to screen and identify human-enriched midline crossing regulators. Work led by Massimo Onesto with Neal Amin
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Our latest work is out today in Science Magazine: a self-organizing system that models organizer-driven patterning and commissural axon guidance in human neural development. This was achieved with human midline #assembloids by combining floor plate and spinal cord #organoids from pluripotent stem cells. A key advance is the three-part configuration (a floor plate squeezed in between two spinal cords), which enables human axons to cross the midline (and the subsequent synchronization of activity between the two parts seen in the video below). This platform opens the door to many applications; here, we used it to screen and identify human-enriched midline crossing regulators. Work led by Massimo Onesto with Neal Amin

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The full video from Cortical Labs explaining how they put 200,000 brain cells onto a silicon chip and had it play Doom is wild: “When a demon appears on the left of the screen, specific electrodes stimulate the sensory area of the neural culture on the left side. The neurons react to that stimulation. We then listen to their response, the spikes, and interpret that activity as motor commands. If the neurons fire in a specific pattern, the Doom guy shoots.”

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Trump recently signed an order to accelerate the rollout of 6G. A recent study found 6G frequencies caused DNA damage in human neural stem cells. 6G is essentially 5G on steroids, utilizing TERAHERTZ frequencies HUNDREDS of times higher than conventional cellular networks.

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2:39

Agree, this is an important point from Michael Baym. A Waymo is an autonomous car even if a human is in the back seat telling it where to go. Same for an Autonomous Lab, scientists can tell it what protocols to do -- quick autonomous lab explainer in this video. It's really about solving for variable lab work, not about taking the scientist out of the loop.

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ANOTHER PANDEMIC? Investigators found thousands of vials of blood, tissue, and genetically engineered mice designed to carry COVID, HIV, Hepatitis, and Malaria. The lab was being run by a Chinese national receiving funding from the CCP. He was only hiring other Chinese nationals to work in the lab and steal American intellectual property. We need to stop letting in Chinese nationals!

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