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We very much welcome a postdoc who is interested in single-nucleosome imaging/analysis to reveal how chromatin behaves in living human cells! NIG offers Postdoctoral Fellowship:

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Kazuhiro Maeshima

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86,244 просмотров • 3 лет назад •via X (Twitter)

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Комментарии: 10

Фото профиля Kazuhiro Maeshima
Kazuhiro Maeshima3 лет назад

Left video, oblique illumination or HILO (image series from epi to TIR) with @nikonsolutions TIRF unit. Right, single-nucleosome video with @hama_photon_pr sCMOS camera. Each dot represents a single nucleosome. They are swaying in living human cells!

Фото профиля Aakeel Ahmad
Aakeel Ahmad3 лет назад

Looks exciting!

Фото профиля Kazuhiro Maeshima
Kazuhiro Maeshima3 лет назад

Thank you!

Фото профиля Evangelos Gatzogiannis
Evangelos Gatzogiannis3 лет назад

Oblique (HiLo) microscopy is the tool for this kind of imaging. Nice side-by-side

Фото профиля Kazuhiro Maeshima
Kazuhiro Maeshima3 лет назад

Thank you! Indeed, oblique (HILO) illumination is a great way to see the movements of molecules in living cells.

Фото профиля Alex hego
Alex hego3 лет назад

@Nicolas26538817 What do you think about lattice lightsheet? 🤔

Фото профиля Kazuhiro Maeshima
Kazuhiro Maeshima3 лет назад

@ogehxela @Nicolas26538817 The lattice light sheet is more sophisticated. Oblique illumination, or HILO, is convenient for getting light-sheet illumination.

Фото профиля Victor Leyton
Victor Leyton3 лет назад

Any interest in applying this amazing technology to study NLS nuclear transport???

Фото профиля Kazuhiro Maeshima
Kazuhiro Maeshima3 лет назад

Great point! You can see how the molecules with NLS bind to NPCs and go through them. Originally oblique illumination or HILO was invented for such a study. Please see:

Фото профиля Dan
Dan3 лет назад

@DrBrianStrahl

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