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We very much welcome a postdoc who is interested in single-nucleosome imaging/analysis to reveal how chromatin behaves in living human cells! NIG offers Postdoctoral Fellowship:

Kazuhiro Maeshima

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86,244 次观看 • 3 年前 •via X (Twitter)

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Kazuhiro Maeshima 的头像

Kazuhiro Maeshima3 年前

Left video, oblique illumination or HILO (image series from epi to TIR) with @nikonsolutions TIRF unit. Right, single-nucleosome video with @hama_photon_pr sCMOS camera. Each dot represents a single nucleosome. They are swaying in living human cells!

Aakeel Ahmad 的头像

Aakeel Ahmad3 年前

Looks exciting!

Kazuhiro Maeshima 的头像

Kazuhiro Maeshima3 年前

Thank you!

Evangelos Gatzogiannis 的头像

Evangelos Gatzogiannis3 年前

Oblique (HiLo) microscopy is the tool for this kind of imaging. Nice side-by-side

Kazuhiro Maeshima 的头像

Kazuhiro Maeshima3 年前

Thank you! Indeed, oblique (HILO) illumination is a great way to see the movements of molecules in living cells.

Alex hego 的头像

Alex hego3 年前

@Nicolas26538817 What do you think about lattice lightsheet? 🤔

Kazuhiro Maeshima 的头像

Kazuhiro Maeshima3 年前

@ogehxela @Nicolas26538817 The lattice light sheet is more sophisticated. Oblique illumination, or HILO, is convenient for getting light-sheet illumination.

Victor Leyton 的头像

Victor Leyton3 年前

Any interest in applying this amazing technology to study NLS nuclear transport???

Kazuhiro Maeshima 的头像

Kazuhiro Maeshima3 年前

Great point! You can see how the molecules with NLS bind to NPCs and go through them. Originally oblique illumination or HILO was invented for such a study. Please see:

Dan 的头像

Dan3 年前

@DrBrianStrahl

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