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We’re seeing China’s booming longevity industry & its rapid evolution. Day 2|#7thTimePieLongevityForum Beyond understanding why we age, the focus is shifting toward how longevity clinics work, how to integrate with healthcare system, how longevity tech can be part of daily life.

14,801 views • 1 month ago •via X (Twitter)

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Today’s guest on the Free Radicals podcast is Michael Ringel, JD PhD, COO Life Biosciences and former Managing Director at Boston Consulting Group. Michael is a leader in longevity and pharma who spent 25+ years advising top pharma companies on their R&D strategy. He is now COO at Life Biosciences where he is bringing the first ever partial epigenetic reprogramming therapy to human clinical trials - a major milestone for the longevity industry. In this episode, we discuss Michael’s insightful paper on why aging is an optimization by evolution, why that means it’s malleable, and how to push the longevity field forward. Michael also sits on the US board of Hevolution Foundation and on the board of the AFAR. Be sure to follow me and Eric Dai to stay up to date on the latest news in longevity biotech! 0:00 Intro 2:30 Why aging is an optimization by evolution 15:10 Why scientists miss the role of evolution in aging 19:31 Evidence that aging is a regulated process 24:40 Hormesis and adaptive stress responses 28:55 The promise of partial epigenetic reprogramming in humans 35:08 Life Bio's first therapy proceeding to clinical trials 47:47 Why targeting the eye, particularly glaucoma and NION, is a strategic choice 52:03 The pharma industry's perspective on anti-aging research 56:39 The importance of public engagement for funding and policy change 1:05:42 Reasons for optimism in longevity 1:08:26 Advice on how to have an impactful and interdisciplinary career 1:11:54 The ethical case for longevity 1:17:34 Concrete steps for audience members to support longevity research

Daniel Shur

16,988 views • 7 months ago

"Aging is the process of a complex system slowly falling into its chaotic disequilibrium. And it's not like evolution necessarily even set a lifespan for us. It is merely the result of, once the system has been established, how long its intrinsic property stayed ordered before it became disordered." I’m excited to share my conversation with Jacob Kimmel of NewLimit. Every species who has ever lived has one shared certainty: we’ll age, decay, and die. Jacob and his team are among the small group of people on earth with the expertise and funding to work on this problem. We talked about why we age, whether cellular aging can actually be reversed, how evolution shaped our lifespan and our peaks, and how AI is fundamentally changing the next era of science. Recorded at New Limit’s HQ in South San Francisco. Timestamps: 00:00 Intro 01:25 Why Evolution Limits Lifespan 03:13 Evolution Tradeoffs Explained 07:44 Why Women Live Longer 10:15 Lessons from Long Lived Species 16:20 Peak Intelligence 23:26 What is Aging? 27:59 Yamanaka Factors 32:18 New Limit 33:56 AI's Role in Progress 37:28 Organ by Organ Longevity 40:28 Is Immortality Possible? 42:04 Lifespan Progress 45:44 How to Test Longevity Drugs 49:30 Placebo Mind Body Link 53:56 What longevity hacks actually work? 57:25 Peptides And Stem Cells 01:00:34 Gene Editing 01:05:10 Personalized Medicine 01:08:48 Philosophical Dilemmas of Longer Lifespans 01:14:57 Living Off Earth 01:16:55 AI And Bio Risks

Sabrina Halper

22,082 views • 4 months ago