A sneak peak of a complex and technically challenging... experiment that my lab developed: Super proud of PhD candidate Hannah Johnson for showcasing our Whole-gut spatial genomic analysis in #zebrafish. This video illustrates one landmark in the protocol after multiple rounds of sequential #HCR and 3D imaging in zebrafish larvae to reveal spatial expression of numerous mRNAs in the same specimen. Data from these imaging data sets are then computationally analyzed for spatial cell groups, spatially variable genes, and differentially expressed genes along 3D. We are leveraging this systems-level SGA to uncover unappreciated mechanistic insight at the cell and tissue levels into #ENS construction. Stay tuned for our work that exploits this pipeline within various mutant and perturbation conditions. Reach out if you are interested in trying this! #fruitypebblesshow more

Our analysis of Israel’s so-called ‘humanitarian bubbles’ indicates that... this new system of aid distribution is simply an extension of the existing architecture of spatial control. The routes established for civilian access to these aid distribution centres (in blue) are continuous with Israeli military raid routes (in red), forming a militarised network designed to facilitate forced displacement and population control.show more

Wonderland: Navigating 3D Scenes from a Single Image Contributions:... • First, we introduce a representation for controllable 3D generation by leveraging the generative priors from camera-guided video diffusion models. Unlike image models, video diffusion models are trained on extensive video datasets. This enables them to capture comprehensive spatial relationships within scenes across multiple views and embed a form of "3D awareness" in their latent space, which allows us to maintain 3D consistency in novel view synthesis. • Second, to achieve controllable novel view generation, we empower video models with precise control over specified camera motions. We introduce a novel dual-branch conditioning mechanism that effectively incorporates desired diverse camera trajectories into the video diffusion model. This enables expansion of a single image into a multi-view consistent capture of a 3D scene with precise pose control. • Third, to achieve efficient 3D reconstruction, we directly transform video latents into 3DGS. We propose a novel latent-based large reconstruction model (LaLRM) that lifts video latents to 3D in a feed-forward manner. With this design, during inference, our model directly predicts 3DGS from a single input image, effectively aligning the generation and reconstruction tasks—and bridging image space and 3D space—through the video latent space. Compared with reconstructing scenes from images, the video latent space offers a 256× spatial-temporal reduction while retaining essential and consistent 3D structural details. Such a high degree of compression is crucial, as it allows the LaLRM to handle a wider range of 3D scenes within the reconstruction framework, with the same memory constraints.show more

If you buy beef from us, you deserve to... know what you are supporting. This is the foundation of our herd, and the kind of selection that leads to cattle that perform well year after year and produce beef with consistency. Our bulls are built for rough terrain and hot weather, and they are expected to hold up when conditions are not easy, because that is real ranching and that is what our country asks of them. Great beef starts right here, and we are proud of how we raise it. 🛒Easy shopping at 🇺🇸 Delivery anywhere in the USAshow more

True, even a two DOF system can exhibit chaotic... behavior, and a single cell is an at least an ~10^7 DOF system (i.e., protein molecules per cell). I still fail to properly convey to others the insane complexity I see in our microscopes, and why successes like AlphaFold only work because of the huge number of unnatural constraints placed on the training data. Case in point (below): lysosome dynamics over 12 min across a 200 x 70 um region in the head of a developing zebrafish embryo, color-coded by depth -- just one of 20k proteins at work. Our Cell Observatory Initiative is more important than ever, but while we have petabytes of the most mind-blowing data ever, we are still hamstrung by insufficient AI talent and compute -- two resources in great demand everywhere. If anyone can help us over this hurdle, we'd be eternally grateful.show more

🎉 England’s ban on glue traps comes into force... today! 🎉 We are thrilled that, from today, it is illegal for members of the public to use glue traps to catch mice and rats in England. Our campaign to end the use of these cruel traps has played a monumental role in this success and we are incredibly proud that after years of tireless campaigning, we are now seeing this ban come into law! 🐁🐀💚 (1/3)show more

Biomni Lab lets biologists collaborate with AI agents to... finish complex tasks end-to-end. Here are 15 popular use cases, each link is a full replay so you can watch the agent work through every step: 1. Spatial transcriptomics analysis: map gene expression across tissue architecture from spatial transcriptomics data, with spatial clustering and neighborhood analysis. 2. Binder design: design de novo protein binders against a target structure using computational protein design tools. 3. Biomarker panel design: identify and optimize a multi-marker diagnostic or prognostic panel from omics data. 4. Clinical trial landscaping: search and summarize the trial landscape for a disease area, mapping phase, endpoints, and sponsor activity. 5. Survival analysis: pull clinical and expression data, fit Cox models, generate Kaplan-Meier curves, and identify prognostic markers. 6. scRNA-seq processing and annotation: from raw counts to UMAP clustering, marker gene detection, and automated cell type labeling. 7. Cell-cell communication: infer ligand-receptor interactions between cell types from single-cell data and map intercellular signaling networks. 8. Primer design for novel Cas13: analyze a putative Cas13 protein from a metagenomic screen—verify the ORF, identify HEPN domains, and design cloning primers with restriction sites and a FLAG 9. Proteomics differential expression: normalize mass spec data, run statistical tests, and visualize differentially abundant proteins. 10. Gene regulatory network inference: reconstruct transcription factor-target gene networks from expression data and identify key regulators. 11. Gene co-expression network analysis: build weighted co-expression networks, identify gene modules, and correlate them with phenotypic traits. 12. Microbiome analysis: process 16S/metagenomic sequencing data to profile microbial communities, diversity, and differential abundance. 13. Polygenic risk scores: compute and evaluate PRS from GWAS summary statistics against a target cohort. 14. Variant annotation: annotate genetic variants with functional predictions, allele frequencies, and clinical significance. 15. Fine-mapping: narrow GWAS loci to credible causal variants using statistical fine-mapping methods. Each of these would normally take days to weeks of scripting, debugging, and iteration. In Biomni Lab, the agent handles the full execution while you steer the science. Learn more:show more

The U.S. Special Presidential Envoy for Ukraine, General Keith... Kellogg Keith Kellogg, is in Kyiv today. I am grateful for a constructive meeting. We discussed various vectors of cooperation – how to achieve real peace and guarantee Ukraine’s security. These include projects within the PURL initiative for financing production and procurement of Patriot systems, strong bilateral agreements on co-production of drones and weapons that we have proposed to America. We count on a positive response from the United States. We had a substantive discussion on stepping up pressure on the Russians and what we can do together with partners in tariff and sanctions policy to enable a meeting at the leaders’ level at the earliest and bring this war to an end. A trilateral leaders’ format is undoubtedly the most effective. We also discussed the return of abducted Ukrainian children, international cooperation on this track, and the conditions in which our children are being held. I expressed condolences to the American people over the horrific murder of Charlie Kirk and thanked President Trump for his condolences and response to the brutal murder of Ukrainian citizen Iryna Zarutska in North Carolina. It is important that justice prevail every time violence seeks to take hold. We are also preparing for the 80th session of the UN General Assembly in New York. We discussed planned events, coordination between Ukraine and the U.S., and work within the Coalition of the Willing. We are working on potential meetings and various formats.show more

Here’s a sneak peek! In celebration of our fandom's... 1st anniversary, we have gathered in the beautiful Beverly Hills, Cebu. Despite the numerous challenges and chaos we've encountered along the way, what truly matters is that we have remained steadfast in our support for Kaisha and Rainah. Our dedication to them has kept us united, and we are excited to commemorate this special milestone together. It's all about Kai and Rain 💜 #KaiRainshow more

At $HASHAI, we are committed to both delivering against... our strategic and operational goals as well as providing transparency to enable trust for new and existing investors alike. We are delighted to show you a short video that demonstrates and verifies our new infrastructure, which is part of our $3 million international expansion. In this video, you will see one of our international sites, which has the benefits of gas and water cooling jackets. Our S19-XP’s are installed and running, currently being stress tested with our #AI algorithms, and a "go-live" date will be communicated within the next week. The whole team will be visiting this site very soon, and further videos will be posted for our community every step of the way.show more

Yeaah with Kartel.ai and Jesse Wellens ! So training... Lora for character on Flux and also for Wan 2.1 14B ( using dataset video ) make a Huge difference. So here you are seeing a volumetric capture of Jesse Wellens that we did in at the spatial studio of Kartel.ai We use a a World Labs gaussian splatting to create a simple environment that we put with the volumetric capture in our own webgl viewer ( out soon for everyone ). After that, We use after this output in a ComfyUI workflow with Wan Fun control ( a bit similar Vace but its working for Wan 14B) with the double loras , the first to generate the first frame with flux, and the second one to guide the generation of Wan 2.1 Control. So we keep very good consistency of character and position, and creating amazing worlds :) ! Hope you will find it cool !show more

Trick-or-Treating is not dead, just concentrated and organized. In... our neighborhood, residents are advised to buy 1500 pieces of candy. That is usually not enough, so we end up closing early. The line in this video will last for two hours, and at a strict one piece per child, will consume our 30-lb stockpile. We are the White neighborhood surrounded by non-white neighborhoods. If you want this for your neighborhood, you must make a production of it. Ask the police to barricade the street, and announce it in the newspaper.show more

BIG NEWS. The Blockworks website has evolved: yesterday we... were the home of news, today we are the home of onchain data. Head over to the site to see for yourself, but here's a little snippet of what you can expect: 1. Sector leaderboards (chains, DEXes, borrow lend, DATs, etc...) 2. Comprehensive data dashboards protocols 3. The ability to compare pricing and onchain data easily (coming soon) We're doing this because the industry still has a gigantic data problem. As investors get more sophisticated and fundamentals driven, basic high level facts are no longer sufficient. Investors need to be able to trust the data they are seeing and go much deeper than the surface level info that's available today. Additionally, because many data providers allow companies to essentially self report, you can't trust what you are seeing. This site is our contribution to fixing that problem and to ensuring clear, accurate data for investors. Blockworks is fully dedicated to becoming the most comprehensive data company in crypto in 2026. This is the first of many, many announcements like this this year, stay tuned.show more

The most detailed 3D reconstruction of a cell ever... created. Blows my mind every time. But what exactly are we looking at here? The average human cell contains: ~ 15-20 total distinct organelle types, totalling between ~1-10 million working together per cell. All these nano-machines in the cell are made up of proteins. ~ 8,000-10,000 distinct types of unique proteins, adding up to between 40 million - 10 trillion total proteins making up all those cellular systems. ~ 10,000 - 15,000 distinct types of RNA shuttling information around the cell, totalling up to ~10 million RNA molecules moving around the cell simultaneously. ~ Billions of Lipid molecules packed together into the cell membrane, which is also packed tightly with millions more protein-based nano-machines. And let's not forget billions of lines of DNA information to build and run it all. That's TRILLIONS of of individual molecular pieces working together to make a single cell function. That means there is more complexity in a single cell than humanity's largest cities. And people still believe this wasn't Divinely Designed. This is God's Glory on Display. But to make the point. A cell couldn't have evolved from some nebulous simpler "protocell" because even the simplest cells still require massive complexity. The "simplest" cell ever created was engineered by scientists knocking out pieces of a functional cell until it stopped functioning. Here is what they found is the absolute necessary minimal requirements of a cell to function: - Over ~531,000 lines of coded DNA information - 473 total genes to create hundreds of unique protein products (they later added 19 genes back in because the cell was so weak) - Hundreds of thousands of total proteins all working together - Extensive regulatory networks guiding all these interactions If the cell doesn't have all these systems in place, from the start... it doesn't live. Cell rely on an intricate network of complex systems, which are themselves built from complex interconnected pieces woven together into an incomprehensibly complex web of functionilty. Only intelligence has ever been observed creation vast interconnected systems like this. Life was clearly Created. It couldn't happen any other way.show more

🚨 Alert. Some drones have gone out of control... and are falling into the ocean and various areas around Male’, as seen in this video. Please take cover immediately. There’s a risk that one could fall on you. The airspace remains closed due to this situation. MACL is waiting for the remaining uncontrolled drones to run out of battery and fall. Stay indoors and stay safe. #minivan60show more

PHOTON COUNTING CT AND A NEW CONCEPT OF NORMAL... CORONARY ARTERIES For more than 2 decades we have been performing Cardiac CT with constant improvements in all parameters (spatial, temporal and contrast resolution). The improvements were progressive in certain fields and steep in other (e.g.: the introduction of Dual Source CT that completely changed the range of temporal resolution achievable basically overnight and still is the most important source of flexibility in Cardiac CT scanning after almost 20 years). Spatial resolution instead was improved in a slow and progressive way until the test EID CT generations that achieved a spatial resolution of 250 microns. This allowed us to assess a coronary artery tree and define it as normal when no apprentice changes were visibile up to that value. But we know that the normal thickness of coronary artery walls is quite below that threshold. It is more in the range of 80-200 microns. Therefore, the very early changes in coronary artery wall thickness could not be picked up by EID CT technology. With the introduction of PCCT we can constantly achieve 100 microns spatial resolution which means that we work extol in range in which coronary artery disease starts. It also means that we don't see any thickening of the the coronary artery walls we have a much higher specificity and reliability. This concept is a transformative one because it allows us to shift earlier and earlier the beginning of atherosclerosis in our patients and think even more precisely in terms of cardiovascular prevention and monitoring. Movie: example of normal coronary artery tree with PCCT. A new era is coming into practice and it is the age of Photon Counting CT which pushes this boundaries further away. PCCT is a NEW Imaging Modality. PCCT is changing the game, the field, the language, the priorities and in the end it will change the entire infrastructure of diagnostic medicine. PS: note that PCCT images have to be reduced in resolution when uploaded in social media. #CardiacImaging #MedicalInnovation #StentAssessment #Radiology #PCCT #photoncounting #QuantumHD #CT #computedtomography #yesCCT #coronaryarterydisease #ischemia #naeotomalpha #Peak #Pro #Prime #speed #cardiac #highresolution #siemenshealthinners #CardiacCT #PhotonCountingCT #MedicalImaging #HeartHealth #CardiovascularInnovation #Radiology #AIInMedicineshow more

This entire club at a public school in California... gave their lives to Jesus! Did you read that? Over 350 students during school hours said yes to the Lord. We are in the beginning stages of awakening in the United States of America. If you’re more aware of tucker Carlson and Candace Owens than you are the kingdom of our God it’s time for a reality check. We are living in one of the greatest moves of God on this side of eternity! Do you believe it?show more

HapdZi Birthday, Sam! As many of you are aware,... as part of this year's "Sam's Birthday Fundraiser" we have been raising funds for the dZi Foundation. The dZi foundation works along side communities in Nepal providing support, infrastructure, knowledge, education, and upskilling, whilst working towards sustainability and self-sufficiency. They are doing truly amazing work within these communities and I am so very glad that they are this year's recipient. Now for the exciting part! Drum roll, please... I am very proud to announce that we were able to raise $32, 290USD! Yes, you read that correctly! $32,290USD! Thank you to everyone who has donated, those who were cheerleaders, and those who were donators and cheerleaders. I am so incredibly proud of our community and I hope that you are too! You guys are fabulous! I would also like to extend my sincere thanks to Jake Norton for sharing his love of Nepal and its people with us. By sharing his memories, and parts of his recent trip with Sam, we were able to have a personal connection with both the people and the places that our donations will benefit. For that I will always be grateful to Jake. I would also like to thank Jake for his very, very generous donation match during the last week of the fundraiser. It was great to see Jake ensure that "Sam" finally made it to the top of "Everest." (Where there's a will, or in this case, a Jake, there's a way!) As always, it is lovely to hear from the organizations that we raise money for each year and this year is no different. Please take a moment to listen to this lovely message of thanks from Wende Valentine, Executive Director at dZi. It is reminder of just how important our philanthropy is, and, that wherever we are in this wonderful world of ours we can always make a difference in the lives of others. "It takes a village. Ours just happens to be sparkly." #SamHeughanshow more

WOW! This is the view from the The George... Washington bridge running from Manhattan, New York to New Jersey. - This is all stemming from Central Canada, where wildfires are burning in the provinces of Ontario and Quebec. - In total there are 211 reported wildfires burning in these two provinces, with 145 of them considered "out of control". - These fires started because of unseasonable hot and dry conditions, and have already forced 10,000 residents to evacuate their homes in Quebec. I think what this shows us is how fragile and interconnected the entire world really is environmentally. An event that takes place in another country can have major impacts and implications on our own. We are all in this thing together. Let's get along and work together to figure things out. The environment is a great place to start.show more

[Preview: Hood's Dynamic skin - Elegance Meant for One]... These garments are a part of my promise to you. The eternity we've spent side by side, and our vow that has weathered many a storm, are a most fitting match for the radiance of this ring. *Content is in development and may not reflect the final version. #AzurLane #Yostarshow more

🔬🤖Excited to share our new preprint on robust virtual... staining of key organelles! ✨ Virtual staining and segmentation of nuclei and cell membranes in phase images can significantly accelerate image-based screens and developmental studies. 🔍 Current virtual staining models often struggle with nuisance variations in label-free input and don't generalize well to new cell types. We’re releasing our training protocols that lead to robust models and enable few-shot generalization. 🔧 Stay tuned for our revamped codebase with weights and example data, coming soon! 👏🧫🐟 Huge shoutout to Ziwen Liu, Eduardo Hirata-Miyasaki, my team Chan Zuckerberg Biohub Network (Soorya, Johanna, Christian, Talon Chandler, Ivan Ivanov), and the teams of Manuel Leonetti, Carolina Arias, and Adrian Jacobo for this fun collaboration! #VirtualStaining #DL #CellBiology #Zebrafishshow more