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A new study found VITAMIN C + GRAPE SEED EXTRACT shrunk cancerous tumors BETTER than one of the strongest chemotherapies in existence WITHOUT destroying the body. In animal models: ✅Vit C + GSE (non-toxic): 77% tumor reduction 🚫Doxorubicin ("RED DEVIL"): 69% tumor reduction

21,995 次观看 • 1 个月前 •via X (Twitter)

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"Biopsies Spread Cancer...Biopsies Are The Kiss Of Death. The Needle Punches A Hole In The Tumor, Dragging Cancer Cells & Spreading Them." Dr Ben Johnson Doctors Finally Admit That The Very Test Being Pushed On Patients Is Causing Cancer To Metastasize All Throughout The Body. The body self-contains a tumor within a fibrin sheath. A needle biopsy breaks the seal of the tumor that kept it contained & allows the pathogenic toxins &/or parasites to be unleashed. When a hornet's nest is poked, it doesn't calm the hive...it angers & scatters. That’s what happens when a needle pierces a tumor. Cancer cells are dragged into new territory, inflammation flares, the immune system gets distracted, and the “nest” gets angrier. Cells are dragged along the needle tract. Local inflammation activates tumor growth. The immune system is suppressed & cancer cells invade tissue, blood & lymph. Biopsies trigger metastasis, inflammation & tumor seeding: "Biopsy of primary tumors resulted in significantly increased incidence & number of lung metastasis."(PMID 25061543) "Biopsies promote intraperitoneal tumor dissemination & progression." (PMID 23258276) "Core needle biopsy of breast tumors increases distant metastases. (PMID 25425969) "Biopsies lead to tumor cell dissemination & seeding of malignant tumors." (PMID 22686607) "Human breast cancer biopsies enhance adjacent cancer cell proliferation." (PMID 27249999) Top Doctors Are Now Admitting 'That Standard Of Care' Is Killing Patients: "Manipulation of an intact tumor...is associated with an increase in the incidence of sentinel node metastasis." (John Wayne Cancer Institute 2022) "Cutting out a section...endangered the person's life by aggravating the malignant growth." (Dr Perry Nichols) "Biopsies spread early cancers." (Dr Jonathan Wright) "Biopsies introduce cancer cells into the bloodstream." (Dr Leonard Gomella) "Biopsies cause cancer cells to spread & the risk is higher in certain types of cancers like prostate & kidney cancers." (Dr Hal Schofield) "Biopsies cause cancer to disseminate further into the body & this has serious implications to patient outcomes." (Dr Robert Nagourney) Alternative Tests That Do Not Disturb Fibrin Sheath Of The Encapsulated Tumor: 1⃣ Multiparametric MRI (pmMRI): Non-invasive. No ionizing radiation. Detects structure & function in high resolution. 2⃣ Color Doppler Ultrasound: Maps tumor blood flow in real time. No radiation. No compression damage. 3⃣ Liquid Biopsy (ctDNA /CTC Testing): Blood test for cancer DNA or cells. No mechanical disruption of tumors. 4⃣ Thermography: Non-radiation, non-invasive technique that uses infrared cameras to detect heat patterns in tumors. Information is anti-fear. Knowledge is power. It gives you choices. It gives you power. If you’ve been diagnosed, please don’t rush. Research. Ask questions. Trust your intuition. Sometimes slowing down is the most urgent thing you can do. The cancer industrial complex is a powerful profit model & needs a massive overhaul. Too many patients blindly walk into these procedures without informed consent, never being told the risks. You can choose to not disturb the tumor at all & instead implement a protocol to shrink & enable the body to eradicate the tumor all together. Many cases of cancer tumors are actually parasitic eggs sacs misdiagnosed as cancer. There are ways to diagnose cancer without the risk of spread & acceleration. And ways to prevent & treat cancer without the harm of Chemotherapy & Radiation. There is a groundbreaking protocol by Dr William Makis, Dr Paul Marik & others that uses Ivermectin, Fenbendazole, Methylene Blue, Fasting, Ketogenic Diet & other proven cancer remission strategies that addresses cancer & parasites simultaneously. ⏩ ⏪ 👇Seeding Tumor Cells Into Metastasis👇 👇Needle Biopsy Promotes Metastasis👇 👇Needle Biopsy Accelerates Cancer👇 Speaker: Justin Stellman

Valerie Anne Smith

770,876 次观看 • 11 个月前

"Your Vitamin C Supplement Has A Dirty Little Secret...Synthetic Ascorbic Acid Is Made From GMO Corn Sprayed With Glyphosate." Dr Paul Saladino, MD Mass Produced In China Thru Fermentation With Black Mold A. Niger. Final Product Isolation Uses Acetone, Ethanol & Sulfuric Acid. Production of synthetic ascorbic acid... "Synthetic ascorbic acid is produced in a lab using Aspergillus Niger, a filamentous black mold fungus & a glucose substrate derived from GMO corn. This method is the common industrial approach for producing large quantities of vitamin C." Research shows synthetic ascorbic acid to be harmful... From the Jun 15, 2001 issue of Science: showed that “synthetic vitamin C contributes to the formation of genotoxins that lead to cancer.” A second study presented to the American Heart Association showed "a link between consumption of only 500mg of synthetic vitamin C per day & a causation for thickening of the arteries." And thirdly, "athletes taking 1000mg of synthetic vitamin C per day showed reduced endurance capacity from interference with antioxidant enzymes" (American Journal of Clinical Nutrition, Jan 2008). Further, synthetic Ascorbic Acid depletes copper reserves, converts to Oxalic Acid to form Calcium Oxalate kidney stones & drives ferritin to toxic levels causing iron overload. 4 synthetic ascorbic acids on ingredient labels... Ascorbic Acid: synthetic Ascorbic Acid from GMO corn & Aspergillus Niger black mold. Mineral Ascorbates: Ascorbic Acid with an attached mineral. Liposomal-C: Ascorbic Acid attached to vegetable seed oils. Bioflavonoid-C: Ascorbic Acid with bioflavonoids added. It is best to get whole food Vitamin C complex from whole fruits & vegetables. When a supplement is necessary, many whole food vitamin C compounds are available for purchase. The ingredient label will say...'Whole Food Vitamin C' from acerola cherries, camu camu berries, rose hips, amla berries, berries, lemons, oranges, limes, etc. Whole food vitamin C is a complex of components that occur naturally. These components work together in the body & isolated synthetic ascorbic acid is not the same as the natural, whole vitamin complex. Whole Food Vitamin C Complex Contains... 14 Flavonoids Rutin Tyrosinase Factor P Factor K Factor J Natural Ascorbic Acid All of these work synergistically to restore & maintain levels of your master antioxidant GLUTATHIONE, crucial for the immune system to fight off bacteria, toxins & pathogens. 90% of all whole compound Vitamin C is stored in the Adrenals for one main reason...it is used to counter & down regulate the stress hormone Cortisol. Whole natural Vitamin C is a vital nutrient for collagen synthesis. Vitamin C converts proline & lysine, two vital amino acids—into collagen. Whole compound natural Vitamin C also plays a critical role in the production of copper rich antioxidants such as SOD(superoxide dismutase) & Catalase that benefit the oxygen carry capacity of Red Blood Cells, Copper Metabolism, energy production & iron recycling. 👇Ascorbic Acid Increases Cardiovascular Risk👇 👇Ascorbic Acid Has No Antioxidant Benefit👇 👇Ascorbic Acid Damages DNA👇 👇Camu Camu Berries vs Synthetic Ascorbic Acid👇 Speaker: Dr Paul Saladino, MD

Valerie Anne Smith

326,437 次观看 • 10 个月前

ASCORBIC ACID Is Not Vitamin C...It Is A Synthetic Lab Created Isolate Chemical Made From GMO Corn & The Black Mold Aspergillus Niger. 99% Of Vitamin C Supplements Are Synthetic, Using Sulfuric Acid & Acetone In Production. Black Mold A. Niger Is Known To Be A Severe Allergen. Over 80% of Ascorbic Acid is made in Chinese Laboratories & fermentation tanks while the remaining 20% is made in the US using the same process: GMO Corn as a Source: Synthetic ascorbic acid is manufactured in bulk using fermented corn syrup, which is derived from GMO corn. A. Niger in Fermentation: Aspergillus Niger black mold is employed in the industrial fermentation process that converts corn-derived dextrose into ascorbic acid. The Process: The process involves refining GMO corn into a sugary syrup, which is then fermented using A. Niger black mold in fermentation tanks to produce ascorbic acid. Solvents & other chemicals like acetone, sulfuric acid, ethanol & methanol are used in the processing steps. Ingredient Labels: If the ingredient label says 'Ascorbic Acid'...you can be 100% certain that what you are consuming IS synthetic Ascorbic Acid from A. Niger black mold. This also includes these 3 additional forms: Mineral Ascorbates: which is ascorbic acid with an attached mineral. Liposomal-C: which is ascorbic acid attached to vegetable seed oils. Bioflavonoid-C: which is ascorbic acid with bioflavonoids added. It's always best to obtain whole food Vitamin C from actual whole foods. If you are not consuming whole foods for your Vitamin C, then these are the supplements you want to look for to purchase: If the ingredient label says 'Whole Food Vitamin C' from acerola cherries, camu camu berries, rose hips, amla berries, berries, lemons, etc...then your Vitamin C supplement contains the whole food compound of natural Vitamin C. Why your body doesn’t like synthetic Ascorbic Acid: Ascorbic acid is a human-made chemical created as a cost-effective additive. 100% synthetic from GMO corn with almost no bioavailability because it is not Vitamin C Compound. Naturally-occurring vitamin C found in food contains the whole compounds & minerals, including rutin, bioflavonoids, K-factor, J-factor, P-factor, tyrosinase (a copper-containing enzyme) & ascorbinogen. If any of these parts are missing, there is no vitamin C & no vitamin activity. You need the whole food to receive the full vitamin, & thus, all of the benefits it yields. Detrimental Effects From Ascorbic Acid: Our bodies do not recognize synthetic ascorbic acid as Vitamin C. Inflammation & health issues will occur. Ascorbic Acid depletes the adrenals & our copper reserves, drives ferritin to toxic levels causing iron overload. Ascorbic Acid also converts to Oxalate within the body & further causes insult to injury with the formation of Calcium Oxalate stones & crystals in the kidneys & other Oxalic Acid illnesses in the body. Synthetic Ascorbic Acid, because it is made by black mold A. Niger fermentation, causes an allergic inflammatory cascade. Ingestion of foods, beverages or supplements containing synthetic ascorbic acid leads to increased inflammation, which then affects the respiratory, gastrointestinal, neurological, urinary & musculoskeletal systems. 👇Ascorbic Acid Increases Cardiovascular Risk👇 👇Ascorbic Acid Has No Antioxidant Benefit👇 👇Ascorbic Acid Damages DNA👇 Speaker: Andy Jay

Valerie Anne Smith

150,650 次观看 • 1 年前

High dose vitamin D supplementation might be doing more harm than good. Stephanie Seneff, MIT researcher: Vitamin D is a signalling molecule, not a nutrient to megadose. It mobilizes calcium — but doesn't control where calcium goes. High dose vitamin D drives calcium into the arteries, leaching it from bones. A 3-year study comparing 400 IU/day, 4,000 IU/day and 10,000 IU/day found the highest dose group had statistically significantly worse bone mineral density. A 2006 study found that calcitriol supplementation (the active form of vitamin D) in young adults with kidney disease increased artery calcification — because calcitriol is taken up directly by cells in the artery wall. Artery calcification is one of the strongest risk factors for cardiovascular disease. An Indian study compared vitamin D supplementation to 20 minutes of daily sunlight in 100 men with severe deficiency. Remarkably — the supplement group had a larger increase in serum vitamin D than the sunlight group. Yet opposite effects on cholesterol: Sunlight group — cholesterol dropped. Supplement group — cholesterol increased. Why? Sunlight and vitamin D supplements take completely different routes through your body. Vitamin D supplements are fat-soluble. The liver has to synthesize cholesterol and release LDL particles just to transport them through the blood. Sunlight stimulates cholesterol sulfate synthesis directly in the skin. The sulfate component makes the molecule water-soluble — transported freely in the blood without being packaged inside an LDL particle. Because cholesterol sulfate is both water-soluble and fat-soluble, it can transfer from skin cell membranes to HDL particles or red blood cells and deliver cholesterol directly to tissues that need it. No LDL carrier required. When you get vitamin D from a supplement instead of the sun, you don't get the simultaneous increase in cholesterol sulfate. The pill doesn't just fail to replicate sunlight. It uses a completely different biological pathway. Seneff: "Vitamin D wants to be subtle. Get out in the sun." "People answer: oh yeah I know, vitamin D is important." "No. Not vitamin D. The sun.” Vitamin D is a proxy for sunlight exposure. The proxy isn't the mechanism.

no.mind

243,668 次观看 • 4 个月前

"Misdiagnosed Cancerous Tumors & Polyps That Are Actually Parasitic Egg Sacs." Dr Bryan Ardis "There's Always An Underlying Parasitic Cause." "Every Research Study On Ivermectin Curing Cancer Is Because It's Actually Parasites." "There Is A Huge Misdiagnosis Of Cancer For Parasites." "70% of all autoimmune diseases such as Rheumatoid Arthritis, Lupus, Fibromyalgia, Sjogren's, MS...there's always an underlying parasitic cause." "50% of all the cancerous tumors & polyps that I was seeing in my patients actually weren't cancer, they were parasitic egg sacs misdiagnosed as cancerous tumors." "Ivermectin is an anti-parasitic drug specifically, but it's being used around the world to combat & cure all types of cancers." Why does that work? Because most of them are parasites. If knowing they are parasites & easily treated, no one would be pressured to do toxic chemotherapy & radiation in cancer treatment centers. If the Oncologists are not taught to look for parasites as the cause or that the cancerous tumor or mass is actually parasitic eggs sacs...If you never got that training you wouldn't even know that was a possibility. If Oncologists never acknowledge this, you would never know there are cheap alternatives to kill parasites & remove them from the human body, all naturally even, versus having to use chemotherapy & radiation to try to kill ALL CELLS in the human body hoping you don't kill the person. Common Parasites & What Organ They Inhabit: Schistosomiasis (Blood Fluke)...reside in the bladder. Opisthorchis viverrini & Clonorchis sinensis (Liver Flukes)...reside in the liver & bile ducts. Toxoplasmosis...causes ocular tumors, meningioma, leukemia & lymphomas. Cryptosporidium parvum...reside in the digestive tract, mainly colorectal. Trichomonas Vaginalis...resides in the cervix & prostate. 🪱Some parasites consume your food from the inside of the body, leaving you hungry & weak even after eating well, unable to gain healthy weight. 🪱Other parasites feed off of your red blood cells, leading to ANEMIA. Some parasites lay eggs, causing ITCHING, IRRITABILITY & even INSOMNIA. A Parasite protocol is important & also heavy metal detox simultaneously because parasites are attracted to a host with heavy metal toxicity. Also important is eliminating the parasites fuel source, which is sugar. A low carbohydrate animal based diet devoid of glucose, sucrose & fructose...starves the parasites of their preferred fuel. Nationally recognized cancer/parasite protocol linked below: If you don't want to use any pharmaceuticals, I can also recommend natural drug free herbal/mineral products that will kill parasites also if anyone asks in replies or DM. 👇Ivermectin, Fenben, Keto, Fasting Protocol👇 👇Ivermectin: Cancer Tumor Cure👇 👇Ivermectin: Anti Parasitic Therapy👇 Speaker: Bryan Ardis

Valerie Anne Smith

649,425 次观看 • 1 年前

SEED OILS Are Poison In A Bottle...Industrialized Seed Oils Are The Most Egregious Assault On Health & Nutrition In The Modern World. Shocking Suppressed Research Reveals These Toxic Seed Oils Touted As 'Heart Healthy' Cause Heart Disease, Cancer, Stroke & Early Death. The half-life of Seed Oils is 680 days. This means that on a cellular level, it takes approximately six years to replace 95% of the toxic seed oils in the body with healthy fats. 100 yrs ago, vegetable oils & seed oils were nonexistent in the daily diet. Today they account for 30% of the daily diet & have made their way into almost every packaged food & restaurant meal we eat. “Vegetable oils” in this context refer to oils extracted from seeds, grains & legumes including but not an exhaustive list: soybean oil, corn oil, sunflower oil, safflower oil, canola oil, rapeseed oil, peanut oil, rice bran oil, grape seed oil, palm oil, linseed oil, sesame oil & cottonseed oil. These oils are all commonly referred to as seed oils. As vegetable oil consumption has grown, rates of obesity, cancer & diabetes–among other chronic illnesses–have surged to unprecedented levels. 6 in 10 adults have a chronic disease & 4 in 10 adults have two or more. Research Showing Direct Disease Causation From Seed Oils: Death: In the Sydney Diet Heart Study: Group #1 consumed butter & Group #2 consumed vegetable oil & margarine. The group consuming oil & margarine had 62% higher death rate over a 7yr period. Heart Disease: In the Minnesota Coronary Experiment, participants who increased their consumption of corn oil & margarine had 86% more heart attacks. Stroke: In the MARGARIN Study, after two years, the number of strokes, heart attacks & cardiovascular deaths was seven times higher in the group eating vegetable oil margarine. Heart Attack: In the Rose Corn Oil Trial, tested replacing butter with corn oil. The result was a 92% increase in heart attacks & a 364% increased risk of death in the group consuming corn oil. Cancer: In the Los Angeles Veterans Administration Study, the group of participants who increased fat from vegetable oil–while keeping total fat the same–were 82% higher rates of cancer. The Tortured Journey Of A Seed To Make Industrial Oil: 1. Chemical extraction via petroleum based solvent (or hexane) 2. Acid wash process (heated to 80°C = 176°F) High Heat = oxidation 3. Neutralization process (heated to 95°C = 203°F) High Heat = oxidation 4. Bleaching process (heated to 110°C = 230°F) High Heat = oxidation 5. Deodorants (heated to 260°C = 500°F) = trans fats → need to use chemical to deodorize because they’ve oxidized so much from the above process that they are colorless & smell awful if consumed as is. 6. Color enhancement After the refining process, what remains is toxic sludge. It Is Time To Return To Real 'Heart Healthy Fats' That Carry No Risk Of Metabolic Dysfunction Or Chronic Disease: Animal Sourced Fats: Butter, Ghee, Tallow, Suet, Lard & Duck Fat. Fruit Oil Saturated Fats: Unrefined Cold Pressed Virgin 100% Coconut & Avocado Oils. 👇Sydney Diet Heart Study👇 👇Minnesota Coronary Experiment👇 👇Los Angeles Veterans Administration Study👇 Video: @LongevityXLab

Valerie Anne Smith

35,051 次观看 • 1 年前

“Ulcers Healed with Vitamin C? The 30% Eradication Rate No One Talks About” Dr. Sarah Myhill dropped a gut health bombshell that deserves way more attention: In a fascinating 1998 Polish trial, researchers gave patients with confirmed Helicobacter pylori infection (the main driver of gastric and duodenal ulcers) nothing but 5 grams of vitamin C daily for 4 weeks. No antibiotics. No proton-pump inhibitors. Just high-dose vitamin C. The result? A full 30% of the treatment group completely eradicated H. pylori. Zero eradications in the control group. (Jarosz et al., Eur J Gastroenterol Hepatol 1998 – small study, but statistically significant and still unreplicated) Dr. Myhill points out something crucial: H. pylori is an upper-gut fermenter that thrives on carbs. Feed it sugar and starch → ulcers worsen. Starve it with strict keto while flooding the stomach with antioxidants and anti-inflammatories? She’s now watched multiple patients clear stubborn H. pylori (and heal their ulcers) using exactly this nutrition-first protocol: - High-dose vitamin C - Ketogenic diet - Targeted iodine + MSM All without the usual antibiotic cocktail that nukes the microbiome. “Nutrition can act like precision medicine when we understand gut ecology,” says Dr. Myhill. 30% ulcer-causing infection clearance from a vitamin alone is not noise — it’s a screaming signal we’ve ignored for over 25 years. Important caveats from Dr. Myhill: - Study was small (n=60) and old — needs modern replication - Won’t work for every case, especially severe or long-standing infections - Always confirm eradication with urea breath test or stool antigen - Bleeding/perforated ulcers are emergencies — seek immediate care if symptoms are severe - This is educational only, not personal medical advice But when 1 in 3 people ditch their ulcer bug with nothing more than vitamin C… isn’t it time we stopped defaulting to antibiotics first?

Camus

15,790 次观看 • 9 个月前

🧬 The Recipe: How One Ovarian Cancer Trial Rebuilds the Immune System the Disease Switched Off A node-by-node case for durable immunity in the cancer that has resisted checkpoint blockade $NWBO and its #DCVax dendritic-cell platform sit at the heart of a new front-line #OvarianCancer trial, the same instructor-cell technology now aimed at the cancer that checkpoint blockade has barely touched. Advanced ovarian cancer kills more women than any other gynecologic malignancy, and it has shrugged off the #immunotherapy revolution almost entirely. Checkpoint blockade on its own reaches an objective response rate near eight percent in this disease, the figure from the $MRK #KEYNOTE-100 trial. The tumors are cold, the mutational burden is low, and the peritoneal cavity is a suppressive field that shuts an immune attack down before it can start. Two decades of single-agent vaccines and single-agent checkpoint drugs have not changed the survival math. Most patients respond to first-line chemotherapy and then relapse, and once the disease returns, the odds turn hard against them. For the patient living that diagnosis, a durable response is the only outcome that counts, and that is the one thing the field has not delivered. A Phase 2 trial opening at #UPMC Hillman in the second half of 2026, #NCT07634094, takes a different route. It does not add one more drug to the pile and hope. It treats ovarian cancer as one clinical face of a single, definable failure, and it rebuilds the broken machinery one node at a time. The sponsors are Pawel Kalinski MD PhD, $NWBO and $AIM. Here is the full logic, and why it is built to produce a response that lasts. 🔒 The hidden lesion: a silencing cascade Ovarian tumors run a self-reinforcing program that switches off the immune system's command center. It starts with chronic inflammation. Senescence-associated secretions and prostaglandin E2, the product of the COX-2 enzyme, keep the signaling protein STAT3 locked on. Persistent STAT3 pulls the silencing enzymes DNMT1 and EZH2 onto a single master gene, IRF8. That gene is the identity switch for the type 1 conventional dendritic cell, the cDC1, the one cell that licenses killer T cells with bioactive Silence IRF8 and the instructor disappears. With it gone, the tumor secretes decoy chemokines that recruit regulatory T cells, killer cells never receive their orders, and the disease grows in immunological darkness. This is not a quirk of ovarian cancer. The same cascade shows up in chronic infection and in aging tissue. Ovarian cancer is one face of a convergent mechanism, which is why a fix that works here points well beyond it. 🔄 The recipe: the cascade run in reverse Every component of the regimen corrects one node of that cascade. Pull out any single arm and the suppression reasserts itself through the others. That is what separates this from a kitchen sink: each part is load-bearing. · Celecoxib lifts the upstream PGE2 brake that keeps the silencing signal switched on. · Autologous, tumor-loaded alpha-DC1 supplies the instructor function from outside the silencing field, loaded with the whole tumor. This is the rebuilt command center the disease erased. · #rintatolimod, the selective TLR3 agonist marketed as #Ampligen, plus interferon-alpha flips the chemokine code tumor-selectively, from the CCL22 that recruits regulatory cells to the CXCL10 and CCL5 that pull in killers. #Bioferon · The alpha-DC1 program imprints CXCR3 and CCR5 homing receptors on the instructed CD8 cells, so they reach the tumor instead of circulating uselessly. · Cisplatin raises stress ligands so the killers can destroy low-antigen escape variants through the DNAM-1 and NKG2D receptors, closing the door on the engine of recurrence. · Paclitaxel plus the interferons repolarize suppressive M2 macrophages back to the supportive M1 state. · $MRK #Keytruda, releases the PD-1 brake last, only after the tumor has been made hot. The order is not cosmetic. The checkpoint comes last for a reason that most combination trials get wrong. 🔗 Why the combination is required, not additive Checkpoint blockade does not activate killer T cells by itself. Published work shows that anti-PD-1 efficacy depends on dendritic cells producing IL-12 inside the tumor (Garris, Immunity 2018). If the instructor is silenced and no IL-12 is being made, pembrolizumab has nothing to set loose. It is releasing a brake on a car with no engine. So restoring the IL-12 signal is the precondition for the checkpoint to do anything in this disease, not an optional add-on to it. The alpha-DC1 vaccine rebuilds the engine. Pembrolizumab takes the brake off. Neither delivers without the other. The relationship is causal, and that is the single idea the whole regimen is organized around. ⏳ Why the response should last A response that fades is not a cure, and durability is engineered here on four fronts at once. · Breadth. The vaccine is loaded with the whole tumor, not a single antigen, so the immune system learns the entire target and the tumor cannot escape by dropping one marker. · A lowered killing threshold. The DNAM-1 and NKG2D signals let killers finish variants that have shed antigen, while the requirement for true tumor recognition is preserved, so normal tissue is passed over. · Memory programming. Bioactive IL-12p70 does what ordinary dendritic-cell expansion cannot. It programs a self-renewing, TCF1-positive stem-like CD8 reservoir, the very population that predicts lasting benefit from checkpoint blockade (Goswami, Clinical Cancer Research 2025). · A self-reinforcing organ. Restored type 1 signaling matures tertiary lymphoid structures inside the tumor, the local factories from which durable immunity is rebuilt long after the last dose. 📊 Already partly de-risked This is not a first guess. The chemokine-and-checkpoint backbone was already tested in recurrent platinum-sensitive ovarian cancer in trial NCT03734692: intraperitoneal cisplatin plus rintatolimod plus pembrolizumab. That study produced an objective response rate near fifty percent, several times the roughly eight percent checkpoint blockade reaches alone in $MRK #KEYNOTE-100, accompanied by the exact chemokine shift the model predicts, the rise in CXCL9, CXCL10, and CXCL11 that a restored type 1 program produces. $MRK collaborated on it and supported it, and the final primary endpoint reported in May 2026. #SITC26 #ASCO26 The new trial adds the missing piece, the alpha-DC1 instructor whose intellectual property traces to #RoswellPark, and moves the whole regimen to the front line, where the tumor is largest and the antigen supply is richest. It is the same spine, established in recurrent disease, now armed with the one component that was absent. 🔬 A trial built to be read, not just won NCT07634094 enrolls twenty-eight patients with Stage III to IV epithelial ovarian, tubal, or peritoneal cancer, chemo-naive, in the neoadjuvant #neoadjuvant setting. #OvarianCancerAwareness #gyncsm #BRCA Treating before surgery buys the cleanest possible readout: the resected tumor itself. The co-primary endpoints are the safety of the full combination and pathologic complete response at debulking. A pathologic complete response, meaning no viable tumor left in the surgical specimen, is one of the most demanding endpoints in solid-tumor #oncology and a recognized marker of long-term benefit. The design also reads the mechanism directly. It looks for the chemokine switch, the rise in intratumoral CD8 cells with a favorable ratio to regulatory cells and a TCF1-positive phenotype, the falling inflammatory tone, and the specific signature of restored pulsed IL-12p70 against preserved bulk IL-12. The study is built to show whether the mechanism engaged, not only whether tumors shrank. Enrollment is expected to begin in the second half of 2026, and because the central readout is the surgical specimen rather than years of follow-up, the first mechanistic signals should arrive relatively early. 🏭 Why this is a platform, not a one-off The instructor cell at the center of this regimen is the same dendritic-cell platform Northwest Biotherapeutics has built its company around. #DCVax extended survival in Phase 3 glioblastoma (JAMA Oncology, 2023), and a UK marketing application is pending with MHRAgovuk. The same approach has already worked in ovarian cancer. At the University of Pennsylvania, a personalized whole-tumor dendritic-cell vaccine in recurrent ovarian cancer was well tolerated and induced broad antitumor T-cell responses that tracked with significantly longer survival, with two-year survival of one hundred percent in the immune responders against twenty-five percent in non-responders (Tanyi et al., Science Translational Medicine, 2018). Those dendritic cells were loaded with the patient's own whole tumor and activated toward the same type 1 program this regimen rebuilds. That is the proof of principle, and this trial is the more complete version of it. The dendritic cell here is engineered for higher, sustained IL-12p70. It is given in the front line, where the antigen supply is richest, rather than in heavily pretreated relapse. The suppressive microenvironment is reprogrammed in parallel rather than left intact, and the checkpoint is released at the end. The Penn vaccine carried the immune response largely on its own. This regimen clears the field for it first, then takes the brake off. The historical knock on personalized cell therapy was manufacturing: bespoke, hand-built, hard to scale. Northwest Biotherapeutics has been answering that directly. #Flaskworks #EDEN, the closed, automated manufacturing system the company acquired, standardizes production and removes the single-site hand manufacturing that limited earlier programs. The Sawston facility #Sawston in the UK, operated by #AdventBioServices, a wholly owned Northwest Biotherapeutics subsidiary, under MHRA good-manufacturing standards, is bringing its first Grade C suite online in 2026, a step anticipated to more than double capacity, with a dedicated leukapheresis clinic already running. The company has also added senior leadership to drive the platform, naming the biopharmaceutical veteran Dr. Annalisa Jenkins as a strategic adviser. The consequence is concrete. If the mechanism reads out in the resected tumor, the system that delivers it is already being built to scale, across the many solid tumors that run the same silencing cascade. One trial, read correctly, does not validate a single drug. It tests a repeatable way of rebuilding antitumor immunity. That reach is the point. The same instructor sits at the center of the silencing cascade across most solid tumors, which is why the dendritic-cell platform is framed around the approach itself rather than a single indication. A front-line ovarian readout that confirms the mechanism would be evidence for the method, not for one tumor type alone. The needle moves on the tissue, not on the thesis, and no paragraph substitutes for the pathology report. What the design offers is a complete, testable mechanism for durable immunity in ovarian cancer, paired with a manufacturing system already capable of producing it at scale. The readout in the resected tumor will speak for itself. Not financial advice. Do your own research. #DCVaxForBraelyn

Andrew Caravello, DO

10,389 次观看 • 2 个月前