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🚨🚨🚨BREAKING🚨🚨🚨 #LMHRstudy / KETO-CTA published! 100 lean, metabolically healthy #keto: 🔥 No association of #ApoB with #plaque ↗️ 🔥 No association of #LDL #cholesterol with #plaque ↗️ 🫀What is association? Existing plaque Read and share 👇👇👇

Dave Feldman

88,049 subscribers

438,239 Aufrufe • vor 1 Jahr •via X (Twitter)

Nachrichten & Politik Gesundheit & Wellness Wissenschaft & Technologie #LMHRstudy #keto #ApoB #plaque #LDL #cholesterol #plaque

Anya Rossi• Live Now

Private livecam show

11 Kommentare

Profilbild von ⭐Fernando Martel García, PhD

⭐Fernando Martel García, PhDvor 1 Jahr

That "plaque begets plaque" is a very unsatisfying explanation. So what starts the plaque in the first place?

Profilbild von Dave Feldman

Dave Feldmanvor 1 Jahr

A crucial question -- but these data are more about looking to our cohort and whether the association of LDL/ApoB is present...

Profilbild von Hungryroot

Hungryrootvor 1 Jahr

"My cholesterol is 1/3 of what it was, I have lost 20 lbs and I feel amazing every day!" - Jessica K, Customer Review

Profilbild von Iain Campbell, Ph.D.

Iain Campbell, Ph.D.vor 1 Jahr

Congratulations Dave, @nicknorwitz, @AdrianSotoMota! 👏 What an incredible journey to bring this from personal experience to published research. Looking forward to the documentary!

Profilbild von Twyla Honey

Twyla Honeyvor 1 Jahr

Congrats 🎉 My cholesterol 325 LDL 215 Triglycerides 64 (Do you want my other lipid panel results?) MD said statins. I said following you and requested CT Calcium Scoring Scan. Results 1 (one). 7 years lc Keto. Thank you for saving me from statins. Will give paper to my MD.

Profilbild von Metabolic Mind

Metabolic Mindvor 1 Jahr

Congrats on the publication @realDaveFeldman; this research is a game-changer for so many people out there!

Profilbild von Dave Feldman

Dave Feldmanvor 1 Jahr

🙏 🙏 🙏

Profilbild von Vatsal G. Thakkar MD

Vatsal G. Thakkar MDvor 1 Jahr

Thanks for your work on this!

Profilbild von Dave Feldman

Dave Feldmanvor 1 Jahr

Can't even believe how long I've waited for this -- and now the day has arrived.

Profilbild von Dr. Stephen Hussey, DC

Dr. Stephen Hussey, DCvor 1 Jahr

Good stuff, Dave. I'd posit that the presence of plaque leads to plaque progression because it changes blood flow dynamics.

Profilbild von Eric Rodgers

Eric Rodgersvor 1 Jahr

Fantastic summary in your video above 😀 Amazing milestone in your epic journey towards helping others.

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🚨🚨🚨🚨🚨🚨🚨🚨 BREAKING: Matthew Budoff MD has now presented the matched analysis for: KETO (#LMHRstudy) vs Control (#MiHeart) -🙏Please RT🙏- METHODS – 80 Participants of #LMHRstudy fell within #MiHeart age range and were then matched 1:1 for age, gender, race, diabetes mellitus, hyperlipidemia, hypertension, and past smoking to asymptomatic subjects from the #MiHeart cohort. PRIMARY ANALYSIS – High resolution heart scans (#CCTA) allowing for primary analysis of Total Plaque Score (TPS), Total Stenosis Score (TSS) and Segment Involvement Score (SIS) RESULTS The matched mean age was 55.5 years, with mean #LDL cholesterol of 272 mg/dL (max LDL-C 591) mg/dl and mean 4.7 years duration on a ketogenic diet. 🚨 There was no significant difference in coronary plaque burden of #LMHRstudy (mean LDL-C 272) cohort as compared to #MiHeart controls (mean LDL 123 mg/dl); nb: pre-KETO LDL-C in KETO group was 122 mg/dl 🚨 There was no significant difference in CAC (median and IQR) [0 (0,56)] versus [1 (0, 49)], p = 0.520 🚨 No relationship of LDL-C elevations and plaque ⚠️ This analysis is on baseline scans and the study is still ongoing for second CCTA completion in our cohort by February of 2024. And as always, please continue to work with your doctor. - I will have my own video reaction and thoughts in the coming hours. 🙏🙏🙏 to everyone -- and I mean everyone -- who helped us get to this pivotal milestone. 🙏🙏🙏

🚨🚨🚨🚨🚨🚨🚨🚨 BREAKING: Matthew Budoff MD has now presented the matched analysis for: KETO (#LMHRstudy) vs Control (#MiHeart) -🙏Please RT🙏- METHODS – 80 Participants of #LMHRstudy fell within #MiHeart age range and were then matched 1:1 for age, gender, race, diabetes mellitus, hyperlipidemia, hypertension, and past smoking to asymptomatic subjects from the #MiHeart cohort. PRIMARY ANALYSIS – High resolution heart scans (#CCTA) allowing for primary analysis of Total Plaque Score (TPS), Total Stenosis Score (TSS) and Segment Involvement Score (SIS) RESULTS The matched mean age was 55.5 years, with mean #LDL cholesterol of 272 mg/dL (max LDL-C 591) mg/dl and mean 4.7 years duration on a ketogenic diet. 🚨 There was no significant difference in coronary plaque burden of #LMHRstudy (mean LDL-C 272) cohort as compared to #MiHeart controls (mean LDL 123 mg/dl); nb: pre-KETO LDL-C in KETO group was 122 mg/dl 🚨 There was no significant difference in CAC (median and IQR) [0 (0,56)] versus [1 (0, 49)], p = 0.520 🚨 No relationship of LDL-C elevations and plaque ⚠️ This analysis is on baseline scans and the study is still ongoing for second CCTA completion in our cohort by February of 2024. And as always, please continue to work with your doctor. - I will have my own video reaction and thoughts in the coming hours. 🙏🙏🙏 to everyone -- and I mean everyone -- who helped us get to this pivotal milestone. 🙏🙏🙏

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💥🫀#LMHRstudy DATA DROP🫀💥 👉 KETO (#LMHR) group had mean LDL-C 272 mg/dl (max 591 mg/dl), age ~55 👉NO INCREASED PLAQUE on CCTA after 4.7 years on #ketodiet vs. to matched control group 👉NO ASSOCIATION between LDL-C and Plaque 👇Clip from vid: More resources: PI, Matt Budoff MD, presentation: Dave's commentary: SELECTED PAST PAPERS Lipid Energy Model: LMHR, first paper: JCL LMHR editorial: RT' Share Widely! More to come... cc' Dave Feldman

💥🫀#LMHRstudy DATA DROP🫀💥 👉 KETO (#LMHR) group had mean LDL-C 272 mg/dl (max 591 mg/dl), age ~55 👉NO INCREASED PLAQUE on CCTA after 4.7 years on #ketodiet vs. to matched control group 👉NO ASSOCIATION between LDL-C and Plaque 👇Clip from vid: More resources: PI, Matt Budoff MD, presentation: Dave's commentary: SELECTED PAST PAPERS Lipid Energy Model: LMHR, first paper: JCL LMHR editorial: RT' Share Widely! More to come... cc' Dave Feldman

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💥The response to yesterday's paper has been UNREAL! My phone hasn't stopped buzzing. If you've been under a rock, here are some highlights in <90 sec 👇 🫀Most participants showed no or minimal progression of coronary plaque 🫀Neither ApoB nor LDL exposure predicted plaque progression 🫀But plaque predicted plaque progression What does this mean, in a phrase: "While this paper doesn't disprove the lipid heart hypothesis, it does help expose a major blindspot." There will be a LOT more coming soon... I promise you that... #Cholesterol #LDL #KetoDiet #ApoB #CAC #CCTA #LMHR #LEM #SaturatedFat #HeartHealth #MetabolicHealth cc Dave Feldman Dr Aseem Malhotra Joseph Everett (WIL) Jan Ellison Baszucki Metabolic Mind Also not, this is not a one off. There have been 10+ papers leading to this moment... and we are just getting warmed up... PMID: 40192608, Plaque Begets Plaque. ApoB does not: Longitudinal data from the KETO-CTA trial PMID: 39372369, Carbohydrate restriction-induced elevations in LDL-cholesterol and atherosclerosis: The KETO trial PMID: 38237807, Increased LDL cholesterol in adults with normal but not high body weight: a meta-analysis PMID: 35629964, The Lipid Energy Model: reimagining lipoprotein function in the context of carbohydrate-restricted diets PMID: 35106434, Elevated LDL-cholesterol with a carbohydrate-restricted diet: evidence for a “lean mass hyper-responder” phenotype

💥The response to yesterday's paper has been UNREAL! My phone hasn't stopped buzzing. If you've been under a rock, here are some highlights in <90 sec 👇 🫀Most participants showed no or minimal progression of coronary plaque 🫀Neither ApoB nor LDL exposure predicted plaque progression 🫀But plaque predicted plaque progression What does this mean, in a phrase: "While this paper doesn't disprove the lipid heart hypothesis, it does help expose a major blindspot." There will be a LOT more coming soon... I promise you that... #Cholesterol #LDL #KetoDiet #ApoB #CAC #CCTA #LMHR #LEM #SaturatedFat #HeartHealth #MetabolicHealth cc Dave Feldman Dr Aseem Malhotra Joseph Everett (WIL) Jan Ellison Baszucki Metabolic Mind Also not, this is not a one off. There have been 10+ papers leading to this moment... and we are just getting warmed up... PMID: 40192608, Plaque Begets Plaque. ApoB does not: Longitudinal data from the KETO-CTA trial PMID: 39372369, Carbohydrate restriction-induced elevations in LDL-cholesterol and atherosclerosis: The KETO trial PMID: 38237807, Increased LDL cholesterol in adults with normal but not high body weight: a meta-analysis PMID: 35629964, The Lipid Energy Model: reimagining lipoprotein function in the context of carbohydrate-restricted diets PMID: 35106434, Elevated LDL-cholesterol with a carbohydrate-restricted diet: evidence for a “lean mass hyper-responder” phenotype

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