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David Sinclair has spent decades reverse-engineering aging inside his Harvard lab. He proved aging is a disease, not an inevitability. He revealed 6 “normal” habits that quietly speed up how fast you age: 1. Replaying a five-minute conversation for five hours.

Lorwen Harris Nagle, PhD

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31,604 просмотров • 2 месяцев назад •via X (Twitter)

Наука и технологии Образование Здоровье и велнес

Anya Rossi• Live Now

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David Sinclair has spent decades reverse-engineering aging inside his Harvard lab. He proved aging is a disease, not an inevitability. He revealed 10 "normal" habits that are secretly speeding up how fast you age: 1. Eating breakfast every single day

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David Sinclair said: "You can reverse aging by 75% in 6 weeks… by reinstalling the "software" of the body so that it's young again." This idea sprouted when he proved in his first experiment that you can accelerate aging in mice: "We took two mice born on the same day—same age, same genetics. We "scratched the CD" of one mouse, corrupting its software and accelerating its aging. The result was dramatic. One looked far older than its brother." He believed if you can give aging, you can also take it away. Tomorrow, I'll share his experiment on how he reversed aging in mice (and then Monkeys). — David Sinclair

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Dr. David Sinclair, a Harvard aging researcher, tested his own biological age and got a number that terrified him. At 48, his blood test came back reading 58. Ten years older than he actually was. He started metformin first. His age barely moved, down to 56. Then he began taking an NAD-boosting molecule his lab had been testing in mice, the same one that reversed mitochondrial aging in old animals within a week. Months later, he retested. His biological age had dropped to 31.4. He wasn't just younger than before. He was younger than his real age by nearly two decades. His nurse called his latest labs "better than perfect." — Dr. David Sinclair on Dr. Mark Hyman's (@markhymanmd) podcast

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Dr. David Sinclair says his lab at Harvard grew a miniature human brain in a dish. Then two small black dots appeared on its surface. They were eyes. These brains are grown from single human cells. They develop the same structures found in a full human brain... They even have measurable brain waves... And under a microscope, you can see calcium signals firing like fireworks. This indicates neurons are communicating with each other in the same way neurons in your brain are firing right now as you read this. After about a year, the firing fades and the brain loses function. Sinclair says when his team treats these aging brains with three "longevity" genes called OSK, the firing comes back on. They have also introduced Alzheimer's disease into these brains. Using the same three genes, it reverses. He says this technology is not limited to brains. His lab has reversed aging in the eye, liver, kidney, and skin. Every tissue responds to the same treatment. Now the first human trial is coming. — David Sinclair (David Sinclair) on Tom Bilyeu's (Tom Bilyeu) podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. Tickets available in the comments below.

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Caught up with David Sinclair on the pod, our best conversation to date. We covered: -- progress on a pill to reverse aging -- gene therapy breakthroughs and AI's role in reprogramming life -- when trials to reverse epigenetic aging in humans will begin -- controversial molecules: NMN, NAD+, rapamycin, and more -- Sinclair’s personal protocol: fasting, fitness, and what actually works -- women's health, economic implications, and ethical landmines -- the truth about age reversal and where we go next

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🚨David Sinclair: “The first potential human age-reversal technology is in people right now.” ROGAN: “What is the current state of science as applied to longevity treatments?” SINCLAIR: “We have a human clinical trial.” ROGAN: “If people get old and we understand the mechanism, why couldn’t we reverse it?” SINCLAIR: “My colleagues and I found that aging has a root cause that’s the same in pretty much every cell in the body, and that we could control that.” “In 2020, we had a big publication that showed we could actually safely, for the first time, reverse that process, like reinstalling software in the cell to make it work again.” ---- The treatment is ER-100, an experimental epigenetic reprogramming gene therapy being developed by Life Biosciences, a company co-founded by Harvard geneticist Dr. David Sinclair. In the current FDA clinical trial, the therapy is delivered by injection into the eye. If this works in humans, it could be a major step toward actually reversing aspects of biological aging rather than simply slowing them down. Joe Rogan David Sinclair

🚨David Sinclair: “The first potential human age-reversal technology is in people right now.” ROGAN: “What is the current state of science as applied to longevity treatments?” SINCLAIR: “We have a human clinical trial.” ROGAN: “If people get old and we understand the mechanism, why couldn’t we reverse it?” SINCLAIR: “My colleagues and I found that aging has a root cause that’s the same in pretty much every cell in the body, and that we could control that.” “In 2020, we had a big publication that showed we could actually safely, for the first time, reverse that process, like reinstalling software in the cell to make it work again.” ---- The treatment is ER-100, an experimental epigenetic reprogramming gene therapy being developed by Life Biosciences, a company co-founded by Harvard geneticist Dr. David Sinclair. In the current FDA clinical trial, the therapy is delivered by injection into the eye. If this works in humans, it could be a major step toward actually reversing aspects of biological aging rather than simply slowing them down. Joe Rogan David Sinclair

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Joe Rogan just had the biggest breakthrough moment ever on his show when anti-aging genius David Sinclair explains how he will be able to create a society where 92 year olds can date 25 year olds: SINCLAIR: “If a 92 year old could be 25 again, would you have sex with them?” ROGAN: “Hell yeah.” “For some reason people get sooo mad when they see an old guy with a young hot wife.” SINCLAIR: “You will not be able to tell how old somebody is by looking at them.” ROGAN: “Is there a way to stop them from turning you into a baby? Because that’s what I would worry about.” SINCLAIR: “We take 92 year old cells and they stop around 25 years old.” ROGAN: “I don’t want to be a baby again.” SINCLAIR: “It’s not hard at all to reverse aging.” ROGAN: “Wowww.” SINCLAIR: “We could use this to rapidly age a mouse.” ROGAN: “Could a Russian spy inject something in your coffee and you would turn 99 overnight?” SINCLAIR: “We know how to do that.” ROGAN: “Whoa. That’s the dark side of this.” “Do you think people will still lie about their age if everyone looks young?” SINCLAIR: “When we live for hundreds of years, people will be proud of their age.”

Joe Rogan just had the biggest breakthrough moment ever on his show when anti-aging genius David Sinclair explains how he will be able to create a society where 92 year olds can date 25 year olds: SINCLAIR: “If a 92 year old could be 25 again, would you have sex with them?” ROGAN: “Hell yeah.” “For some reason people get sooo mad when they see an old guy with a young hot wife.” SINCLAIR: “You will not be able to tell how old somebody is by looking at them.” ROGAN: “Is there a way to stop them from turning you into a baby? Because that’s what I would worry about.” SINCLAIR: “We take 92 year old cells and they stop around 25 years old.” ROGAN: “I don’t want to be a baby again.” SINCLAIR: “It’s not hard at all to reverse aging.” ROGAN: “Wowww.” SINCLAIR: “We could use this to rapidly age a mouse.” ROGAN: “Could a Russian spy inject something in your coffee and you would turn 99 overnight?” SINCLAIR: “We know how to do that.” ROGAN: “Whoa. That’s the dark side of this.” “Do you think people will still lie about their age if everyone looks young?” SINCLAIR: “When we live for hundreds of years, people will be proud of their age.”

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This is insane 🔥 The FDA cleared the first human age-reversal trial A Harvard professor proved you can reverse aging by 75% in 6 weeks in mice cured blindness, reversed Alzheimer's, MS, ALS, kidney and liver disease then confirmed it works in monkeys Now humans are next. Life Biosciences raised $80M to make it happen His words "The eye is just the beginning. We believe we can treat every tissue. A whole body reset"

This is insane 🔥 The FDA cleared the first human age-reversal trial A Harvard professor proved you can reverse aging by 75% in 6 weeks in mice cured blindness, reversed Alzheimer's, MS, ALS, kidney and liver disease then confirmed it works in monkeys Now humans are next. Life Biosciences raised $80M to make it happen His words "The eye is just the beginning. We believe we can treat every tissue. A whole body reset"

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