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Just finished making this to relate with the low cortisol meme 😆 #meme #cortisol #vrchat This gimmick helps lower your cortisol when you move or dance. It goes back up when you stop having fun Get it now for free:

34,642 Aufrufe • vor 4 Monaten •via X (Twitter)

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Ray Peat on diabetes, cortisol, sugar, and protein: "I saw that several of the amino acids in proteins are powerful insulin stimulants. When you eat protein by itself, you stimulate insulin secretion, which is needed to metabolize the amino acids. In reaction to the insulin, your liver has to put out glucose to keep your blood sugar going, so your brain, blood cells, kidneys, and so on can keep working. If your liver is somewhat low on glycogen, then every time you eat protein and have an insulin secretion, your body secretes a compensating amount of cortisol to bring your blood sugar back up. However, the cortisol brings your blood sugar up at the expense of protein. Cortisol first breaks down tissues like the thymus gland, immune cells, and muscles. If you eat lots of protein, despite the high cortisol, you can maintain a balance by replacing your muscles and thymus gland, but you are running on constantly high cortisol secretion. In my previous interest in diabetes, I saw that doctors often neglected to measure hormones related to blood sugar when prescribing insulin. Doctors would call a person diabetic and say they needed to take insulin for life. But by testing cortisol in some of these individuals, we saw that many so-called diabetics just had very high cortisol. Sugar happens to be the best thing for lowering cortisol to normal. Since high cortisol can give the impression of diabetes by causing high blood sugar, you get the unexpected effect of lowering cortisol when you eat sugar. Some of these people had a very quick recovery from their so-called diabetes."

Master Metabolism

50,214 Aufrufe • vor 1 Jahr

Your 8pm workout is shrinking your brain. It's also building belly fat and more than doubling your odds of dying in the next decade. Andrew Huberman is naming the mechanism. Cortisol is supposed to peak when you wake up and crash by 11pm. Hard training after 7pm spikes it back up at the worst possible window. Four nights a week of evening workouts and the daily curve flattens. The morning peak softens. The evening trough inflates. The shape inverts. A 2017 meta-analysis of 80 studies and 23,000 participants found that flatter cortisol curves predict higher mortality, more inflammation, worse cognition, and greater visceral fat. The hazard ratio for early death was 2.40. Total daily cortisol output didn't predict any of it. Curve shape carried the variance. Whitehall II followed 4,000 British civil servants for six years and got the same answer. Flatter slope, hazard ratio 1.30 for all-cause death, 1.87 for cardiovascular death. Independent of every covariate they measured. Robert Sapolsky's primate work shows what happens next. Subordinate baboons getting harassed daily show lower morning peaks and higher evening troughs than dominant baboons. The flattening comes first. Hippocampal atrophy follows. Cushing's patients show the same loss. PTSD veterans show the same. Three different pathways into chronic glucocorticoid exposure, one consistent brain effect, partially reversible when the curve gets restored. There's another loop running underneath. Visceral belly fat manufactures cortisol locally. The enzyme is 11β-HSD1. It converts inactive cortisone to active cortisol inside the fat cell. Mice with adipose-specific overexpression of this enzyme develop visceral obesity, insulin resistance, and metabolic syndrome on completely normal blood cortisol. The systemic level looks fine. The local tissue is bathed in glucocorticoid signaling. That's why "meditate to lower cortisol" doesn't shrink the belly. The belly is making its own. What rebuilds the curve is cheap. Train hard before late afternoon. Keep the four hours before bed for walks and stretching. Get morning sunlight in the first hour after waking. Anchor sleep timing within a 30-minute window. Each one steepens the morning peak and deepens the evening trough. Total daily cortisol barely moves. The curve gets sharper. Make the morning loud. Make the night quiet.

Aakash Gupta

2,143,843 Aufrufe • vor 4 Monaten