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Massive new vitamin D study just dropped — and it’s getting zero mainstream attention A 4-year trial with 25,000 adults across the US (led by 140 researchers) found: Vitamin D3 supplementation significantly preserved telomere length (only 1 year of aging in 4 years). This follows a 10-year Canadian study...

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Vitamin D supplementation was associated with a 40% lower risk of dementia over a decade. After five years, 84% of supplement users were dementia-free compared to just 68% of non-users in a study of over 12,000 people. Vitamin D reduced dementia risk by 33% in adults with mild cognitive impairment or APOE e4, a key genetic risk factor for neurodegenerative diseases. Vitamin D isn’t just a vitamin—it's a steroid hormone regulating over 2,000 genes critical for brain development, neuroplasticity, and inflammation control. Its roles include clearing amyloid beta plaques and tau buildup, boosting neuron survival via neurotrophic factors like BDNF, and enhancing brain connectivity, particularly when paired with exercise. It’s no surprise, then, that higher vitamin D levels are associated with better cognition, larger hippocampal volume, and lower Alzheimer’s risk. Multiple lines of evidence support this. More than 30 large studies have consistently linked low vitamin D levels to a 50–150% increased dementia risk. People genetically prone to low vitamin D—those with genetic variations affecting vitamin D production or metabolism—have a 54% higher dementia risk. Furthermore, supplementing with 800 IU/day of vitamin D improves memory and cognitive function in people with mild cognitive impairment and more serious forms of dementia. To learn more about optimizing vitamin D levels for cognitive health, including underlying brain-protective mechanisms and practical supplementation protocols, see the latest FoundMyFitness video. Link in comments.

Dr. Rhonda Patrick

245,165 Aufrufe • vor 1 Jahr

High dose vitamin D supplementation might be doing more harm than good. Stephanie Seneff, MIT researcher: Vitamin D is a signalling molecule, not a nutrient to megadose. It mobilizes calcium — but doesn't control where calcium goes. High dose vitamin D drives calcium into the arteries, leaching it from bones. A 3-year study comparing 400 IU/day, 4,000 IU/day and 10,000 IU/day found the highest dose group had statistically significantly worse bone mineral density. A 2006 study found that calcitriol supplementation (the active form of vitamin D) in young adults with kidney disease increased artery calcification — because calcitriol is taken up directly by cells in the artery wall. Artery calcification is one of the strongest risk factors for cardiovascular disease. An Indian study compared vitamin D supplementation to 20 minutes of daily sunlight in 100 men with severe deficiency. Remarkably — the supplement group had a larger increase in serum vitamin D than the sunlight group. Yet opposite effects on cholesterol: Sunlight group — cholesterol dropped. Supplement group — cholesterol increased. Why? Sunlight and vitamin D supplements take completely different routes through your body. Vitamin D supplements are fat-soluble. The liver has to synthesize cholesterol and release LDL particles just to transport them through the blood. Sunlight stimulates cholesterol sulfate synthesis directly in the skin. The sulfate component makes the molecule water-soluble — transported freely in the blood without being packaged inside an LDL particle. Because cholesterol sulfate is both water-soluble and fat-soluble, it can transfer from skin cell membranes to HDL particles or red blood cells and deliver cholesterol directly to tissues that need it. No LDL carrier required. When you get vitamin D from a supplement instead of the sun, you don't get the simultaneous increase in cholesterol sulfate. The pill doesn't just fail to replicate sunlight. It uses a completely different biological pathway. Seneff: "Vitamin D wants to be subtle. Get out in the sun." "People answer: oh yeah I know, vitamin D is important." "No. Not vitamin D. The sun.” Vitamin D is a proxy for sunlight exposure. The proxy isn't the mechanism.

no.mind

240,565 Aufrufe • vor 3 Monaten