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One protein, two opposing roles: This ‘compelling’ study shows how the same signalling molecule can drive either protrusion or retraction in migrating cells depending on its concentration and activation dynamics.

eLife - the journal

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This footage shows a jaguar and a puma using the same trail, but not at the same time. These two big cats were filmed days apart in the Osa Peninsula, Costa Rica, and their movements were combined into one video to highlight how they navigate the same environment

This footage shows a jaguar and a puma using the same trail, but not at the same time. These two big cats were filmed days apart in the Osa Peninsula, Costa Rica, and their movements were combined into one video to highlight how they navigate the same environment

Nature Unedited

47,893 görüntüleme • 4 ay önce

You’re gonna remember this one!! This is a case w/either the most crazy or most predictable ending—depending on how you look at it! It’s in the “I’ve never seen that in my 15 year career” column Patient who had a mesenchymal stem implantation for a remote spinal cord injury. Can you see what happened? Did something go wrong or go right? Watch to the end to find out!!!

You’re gonna remember this one!! This is a case w/either the most crazy or most predictable ending—depending on how you look at it! It’s in the “I’ve never seen that in my 15 year career” column Patient who had a mesenchymal stem implantation for a remote spinal cord injury. Can you see what happened? Did something go wrong or go right? Watch to the end to find out!!!

Lea Alhilali, MD

13,619 görüntüleme • 2 yıl önce

A single E. coli cell, placed on a dish, will become 70 billion cells in just 12 hours. That’s exponential growth. But a new preprint shows that it's possible to engineer E. coli to grow linearly instead, where only one daughter cell continues dividing and the other stops. First, some context. In nature, there is a bacterium called Mycobacterium smegmatis (initially discovered in 1884 in ulcers scraped from syphilis patients.) M. smegmatis is weird because it divides asymmetrically. These cells grow only from one end, and all their cell wall biosynthesis machinery is located on that one end. So when the cell divides, one daughter gets this machinery and the other gets nothing. The daughter that gets the machinery can keep dividing immediately, but the other daughter has to remake all that machinery from scratch, so its growth is delayed. E. coli doesn’t grow like this. When it divides, it pinches in the middle and splits everything evenly. Enzymes, metabolites, and proteins get partitioned more or less randomly between the two daughters. For the new preprint, though, researchers engineered E. coli to behave more like M. smegmatis. Here is how they did it: First, they deleted a gene called cyaA, which encodes an enzyme (adenylate cyclase) that makes a molecule called cAMP. cAMP is SUPER IMPORTANT! It is a nutrient sensor that instructs E. coli to switch on genes that help it digest non-glucose carbon sources when glucose is scarce. Without cAMP, E. coli cells growing on alternative carbon sources will starve; they won’t know how to eat the food. Next, they added back a “split” version of the cyaA gene into the cells. In other words, they split the gene in two so that each half of the enzyme is made separately. Cells can only make cAMP, and thus eat non-glucose carbon sources, if these two halves come together. To facilitate that “coming together,” the researchers also fused the split cyaA proteins to sticky proteins that clump together, and to a fluorescent protein (to make it easy to track these molecules in the cell.) So now some interesting things start to happen if you grow E. coli on a growth medium lacking glucose. As the cell grows, its cyaA “halves” start clumping together into a giant ball. Inside the aggregate, the two enzyme halves come together and make cAMP. And when the cell gets big enough and divides, the clump of cyaA RANDOMLY goes to either daughter cell #1 or #2. The daughter that gets the aggregate (called PA+ in this paper) can keep dividing. The daughter that doesn’t (PA–) cannot. It still grows a few times — about four divisions — because it inherits some leftover cAMP from its mother. But after that, the metabolite is diluted away, and the cell stops growing. PA+ cells went through about 23 divisions on average before their aggregate decayed. And the population of cells, as a whole, grew linearly. This paper is cool because there are many applications where exponential growth is too unpredictable and, perhaps, unsafe. If you want to engineer bacteria to deliver drugs, clean up waste, or live in the gut, you don’t want them to double uncontrollably. This paper shows you can make them expand in a controlled, linear way. Alas, mutations could break this whole engineered system. A mutation that restores cyaA, for example, would give cells a new way to make cAMP. Mutations that make the aggregates split between daughters would break the asymmetry, too. But still, I really enjoy proof-of-concept engineering papers like this.

A single E. coli cell, placed on a dish, will become 70 billion cells in just 12 hours. That’s exponential growth. But a new preprint shows that it's possible to engineer E. coli to grow linearly instead, where only one daughter cell continues dividing and the other stops. First, some context. In nature, there is a bacterium called Mycobacterium smegmatis (initially discovered in 1884 in ulcers scraped from syphilis patients.) M. smegmatis is weird because it divides asymmetrically. These cells grow only from one end, and all their cell wall biosynthesis machinery is located on that one end. So when the cell divides, one daughter gets this machinery and the other gets nothing. The daughter that gets the machinery can keep dividing immediately, but the other daughter has to remake all that machinery from scratch, so its growth is delayed. E. coli doesn’t grow like this. When it divides, it pinches in the middle and splits everything evenly. Enzymes, metabolites, and proteins get partitioned more or less randomly between the two daughters. For the new preprint, though, researchers engineered E. coli to behave more like M. smegmatis. Here is how they did it: First, they deleted a gene called cyaA, which encodes an enzyme (adenylate cyclase) that makes a molecule called cAMP. cAMP is SUPER IMPORTANT! It is a nutrient sensor that instructs E. coli to switch on genes that help it digest non-glucose carbon sources when glucose is scarce. Without cAMP, E. coli cells growing on alternative carbon sources will starve; they won’t know how to eat the food. Next, they added back a “split” version of the cyaA gene into the cells. In other words, they split the gene in two so that each half of the enzyme is made separately. Cells can only make cAMP, and thus eat non-glucose carbon sources, if these two halves come together. To facilitate that “coming together,” the researchers also fused the split cyaA proteins to sticky proteins that clump together, and to a fluorescent protein (to make it easy to track these molecules in the cell.) So now some interesting things start to happen if you grow E. coli on a growth medium lacking glucose. As the cell grows, its cyaA “halves” start clumping together into a giant ball. Inside the aggregate, the two enzyme halves come together and make cAMP. And when the cell gets big enough and divides, the clump of cyaA RANDOMLY goes to either daughter cell #1 or #2. The daughter that gets the aggregate (called PA+ in this paper) can keep dividing. The daughter that doesn’t (PA–) cannot. It still grows a few times — about four divisions — because it inherits some leftover cAMP from its mother. But after that, the metabolite is diluted away, and the cell stops growing. PA+ cells went through about 23 divisions on average before their aggregate decayed. And the population of cells, as a whole, grew linearly. This paper is cool because there are many applications where exponential growth is too unpredictable and, perhaps, unsafe. If you want to engineer bacteria to deliver drugs, clean up waste, or live in the gut, you don’t want them to double uncontrollably. This paper shows you can make them expand in a controlled, linear way. Alas, mutations could break this whole engineered system. A mutation that restores cyaA, for example, would give cells a new way to make cAMP. Mutations that make the aggregates split between daughters would break the asymmetry, too. But still, I really enjoy proof-of-concept engineering papers like this.

Niko McCarty.

58,019 görüntüleme • 10 ay önce

The Dottore we saw in the 6.2 AQ is absolutely NOT Omega - A mini 🧵I suppose YES THIS CONTAINS LEAKS AND SPOILERS We know the VA likes to play with his voice depending on the segment, I can't help but think the one that we saw recently is either OG Dottore or a new segment 1/5

The Dottore we saw in the 6.2 AQ is absolutely NOT Omega - A mini 🧵I suppose YES THIS CONTAINS LEAKS AND SPOILERS We know the VA likes to play with his voice depending on the segment, I can't help but think the one that we saw recently is either OG Dottore or a new segment 1/5

Daily Fatui 🃏

99,041 görüntüleme • 7 ay önce

‼️🇺🇸 Two Turnin, Two Burnin – USS Milius in Action 🔥 The sea is rolling and this destroyer is cutting through the waves as DDG 69 USS Milius shows its power. It is a guided missile destroyer with the Aegis system that can track air and missile threats with high accuracy. It carries vertical launch cells for Tomahawk and Standard Missiles and also uses a five inch naval gun for surface targets. Its sensors and sonar give it strong capability against submarines, making it a complete multi mission warship.

‼️🇺🇸 Two Turnin, Two Burnin – USS Milius in Action 🔥 The sea is rolling and this destroyer is cutting through the waves as DDG 69 USS Milius shows its power. It is a guided missile destroyer with the Aegis system that can track air and missile threats with high accuracy. It carries vertical launch cells for Tomahawk and Standard Missiles and also uses a five inch naval gun for surface targets. Its sensors and sonar give it strong capability against submarines, making it a complete multi mission warship.

Defense Intelligence

153,579 görüntüleme • 7 ay önce

Inside every cell, there is a transport system that determines how materials move, signals propagate, and structure is maintained. This video captures that system in motion. The glowing streaks mark the growing ends of microtubules (protein polymers that constantly assemble and disassemble through a process called dynamic instability). Rather than forming permanent tracks, microtubules are rebuilt continuously, allowing cells to reorganize their internal layout in real time. This behavior is essential for life. Cells rely on microtubule dynamics to divide accurately, migrate during development and repair, and maintain long-distance transport in neurons that may span over a meter in length. When this system is altered, the consequences are significant. Certain cancer therapies work by locking microtubules in place, preventing cell division. In contrast, failures in microtubule transport are linked to neurodegenerative conditions (like Alzheimer's) where intracellular delivery breaks down. What appears as abstract motion under a microscope is actually one of the core systems that keeps cells functional, adaptable, and alive. Video Credit: Andy Moore

Inside every cell, there is a transport system that determines how materials move, signals propagate, and structure is maintained. This video captures that system in motion. The glowing streaks mark the growing ends of microtubules (protein polymers that constantly assemble and disassemble through a process called dynamic instability). Rather than forming permanent tracks, microtubules are rebuilt continuously, allowing cells to reorganize their internal layout in real time. This behavior is essential for life. Cells rely on microtubule dynamics to divide accurately, migrate during development and repair, and maintain long-distance transport in neurons that may span over a meter in length. When this system is altered, the consequences are significant. Certain cancer therapies work by locking microtubules in place, preventing cell division. In contrast, failures in microtubule transport are linked to neurodegenerative conditions (like Alzheimer's) where intracellular delivery breaks down. What appears as abstract motion under a microscope is actually one of the core systems that keeps cells functional, adaptable, and alive. Video Credit: Andy Moore

William A. Wallace, Ph.D.

18,469 görüntüleme • 5 ay önce

World modeling and imitation learning have largely been considered two disparate worlds. In our recent work, Unified World Models, just accepted to #RSS2025, Chuning Zhu provides a dead-simple unifying solution: just train a joint diffusion model over actions and future states, but with *decoupled* diffusion time steps across these modalities. Manipulating these decoupled time steps then allows for marginalization or conditioning on actions or states; a single model can serve as a policy, forward dynamics model, video prediction model, or inverse dynamics model by simply setting diffusion timesteps carefully. The resulting model can leverage video datasets along with robot training data much more effectively, and shows improved robustness, generalization, and flexibility. This is exciting because it is frustratingly simple, scalable, and shows strong improvement on real-world robotics problems. Please refer to Chuning Zhu 's excellent thread for more details! More details/code can be found on our website and in the paper -

World modeling and imitation learning have largely been considered two disparate worlds. In our recent work, Unified World Models, just accepted to #RSS2025, Chuning Zhu provides a dead-simple unifying solution: just train a joint diffusion model over actions and future states, but with decoupled diffusion time steps across these modalities. Manipulating these decoupled time steps then allows for marginalization or conditioning on actions or states; a single model can serve as a policy, forward dynamics model, video prediction model, or inverse dynamics model by simply setting diffusion timesteps carefully. The resulting model can leverage video datasets along with robot training data much more effectively, and shows improved robustness, generalization, and flexibility. This is exciting because it is frustratingly simple, scalable, and shows strong improvement on real-world robotics problems. Please refer to Chuning Zhu 's excellent thread for more details! More details/code can be found on our website and in the paper -

Abhishek Gupta

11,430 görüntüleme • 1 yıl önce

How can Britain be “Judeo-Christian” if Jews were expelled from Britain for four centuries and they have always been <1% of the population? Everyone who uses this term is either a propagandist or a sheep. This is one of the obvious tells about whether someone is on our side.

How can Britain be “Judeo-Christian” if Jews were expelled from Britain for four centuries and they have always been <1% of the population? Everyone who uses this term is either a propagandist or a sheep. This is one of the obvious tells about whether someone is on our side.

Wolf 🐺

43,000 görüntüleme • 2 ay önce

Creed Humphrey on how the team will attack the rest of the season: "It sucks, but we have three games left. You can take it one of two ways: You can mope around, cry about it, or you can come in ready to work and get ready for these next three weeks." #ChiefsKingdom

Creed Humphrey on how the team will attack the rest of the season: "It sucks, but we have three games left. You can take it one of two ways: You can mope around, cry about it, or you can come in ready to work and get ready for these next three weeks." #ChiefsKingdom

Mark Poulose

118,441 görüntüleme • 7 ay önce

Plants don’t have nerves. But when they’re injured, they send an electrical “SOS” that looks very familiar. When a leaf is cut or bitten, glutamate (the same amino acid that acts as a neurotransmitter in humans) spills out of the damaged cells. In plants, that glutamate flips on a series of glutamate-gated receptors, triggering a rapid calcium wave that races through the stem and leaves. It’s not pain. It’s not consciousness. But it is a long-distance danger signal. And what happens next is biology at its best: • Distant leaves ramp up their defenses • Genes for protection and repair switch on • Chemical pathways shift to heal tissue and deter future damage Humans use glutamate to communicate between neurons. Plants use it to communicate between cells and tissues. Two completely different systems, one molecule playing messenger in both. A reminder that living things often solve survival problems using the same biochemical tools… even when evolution sends them down very different paths. From: Gatsby Plant Science Education Program

Plants don’t have nerves. But when they’re injured, they send an electrical “SOS” that looks very familiar. When a leaf is cut or bitten, glutamate (the same amino acid that acts as a neurotransmitter in humans) spills out of the damaged cells. In plants, that glutamate flips on a series of glutamate-gated receptors, triggering a rapid calcium wave that races through the stem and leaves. It’s not pain. It’s not consciousness. But it is a long-distance danger signal. And what happens next is biology at its best: • Distant leaves ramp up their defenses • Genes for protection and repair switch on • Chemical pathways shift to heal tissue and deter future damage Humans use glutamate to communicate between neurons. Plants use it to communicate between cells and tissues. Two completely different systems, one molecule playing messenger in both. A reminder that living things often solve survival problems using the same biochemical tools… even when evolution sends them down very different paths. From: Gatsby Plant Science Education Program

William A. Wallace, Ph.D.

49,974 görüntüleme • 7 ay önce

crazy.. photoshop but for video is here seedance 2.0 now can edit video in layers like ground, sky, bg or objects separately on arcads AI.. and keeps camera and character motion perfectly the same.. this is revolution for film industry here's how to do:

crazy.. photoshop but for video is here seedance 2.0 now can edit video in layers like ground, sky, bg or objects separately on arcads AI.. and keeps camera and character motion perfectly the same.. this is revolution for film industry here's how to do:

el.cine

151,462 görüntüleme • 3 ay önce

If you have Cancer, this is your visualization. That is a cancerous cell reaching Apoptosis and Necrosis—they are gone. — Natural Killer (NK) cells play a the primary role in the immune system's defense against cancer. They induce cancer cell death primarily through two mechanisms: Apoptosis Necrosis Apoptosis is a programmed, non-inflammatory form of cell death, while necrosis is a more abrupt and inflammatory process. In many cases, NK cells can trigger a combination of both, leading to mixed forms of cell death. This dual capability allows NK cells to effectively target and destroy all tumor cells. Their ability to act without prior sensitization makes them vital for early cancer surveillance and curing existing cancer. One of the only ways cancer never starts or stops entirely is NK cells. They are the guerrilla warfare troops that never sleep. This is why it is vital for BioShield by to be approved, NOW for every cancer, not just a single cancer type. With the rest needing years and years of tests. Cancer is cancer, unregulated cell division and NK cells are NK cells. The ONLY thing that stops BioShield is government betrayal, and organized corruption disguised as following the “regulations” designed by the entrenched gatekeepers of corporate protection. Everyone knows it works that has even a molecule of biological understanding. Now you know.

If you have Cancer, this is your visualization. That is a cancerous cell reaching Apoptosis and Necrosis—they are gone. — Natural Killer (NK) cells play a the primary role in the immune system's defense against cancer. They induce cancer cell death primarily through two mechanisms: Apoptosis Necrosis Apoptosis is a programmed, non-inflammatory form of cell death, while necrosis is a more abrupt and inflammatory process. In many cases, NK cells can trigger a combination of both, leading to mixed forms of cell death. This dual capability allows NK cells to effectively target and destroy all tumor cells. Their ability to act without prior sensitization makes them vital for early cancer surveillance and curing existing cancer. One of the only ways cancer never starts or stops entirely is NK cells. They are the guerrilla warfare troops that never sleep. This is why it is vital for BioShield by to be approved, NOW for every cancer, not just a single cancer type. With the rest needing years and years of tests. Cancer is cancer, unregulated cell division and NK cells are NK cells. The ONLY thing that stops BioShield is government betrayal, and organized corruption disguised as following the “regulations” designed by the entrenched gatekeepers of corporate protection. Everyone knows it works that has even a molecule of biological understanding. Now you know.

Brian Roemmele

191,436 görüntüleme • 7 ay önce

Here’s a video of a McDonald's pneumatic ketchup/mustard dispenser that never made it to restaurants (post below). For decades we had two separate dispensers: one for ketchup and one for mustard. We’re looking to make our kitchens faster, one second at a time. They’re pretty efficient, but you had to pick up two different dispensers. Now there’s a single dual-purpose version. It dispenses both at once or either one, depending on how you move the black handle (left for mustard, center for both, right for ketchup). Yes, it’s probably over-engineered. Yes, it works. Yes, it saves time.

Here’s a video of a McDonald's pneumatic ketchup/mustard dispenser that never made it to restaurants (post below). For decades we had two separate dispensers: one for ketchup and one for mustard. We’re looking to make our kitchens faster, one second at a time. They’re pretty efficient, but you had to pick up two different dispensers. Now there’s a single dual-purpose version. It dispenses both at once or either one, depending on how you move the black handle (left for mustard, center for both, right for ketchup). Yes, it’s probably over-engineered. Yes, it works. Yes, it saves time.

McFranchisee

54,382 görüntüleme • 5 ay önce

One of the most intense experiences I remember in a movie theater was watching the Normandy landing in Saving Private Ryan. I wanted to recreate the moment of the landing crafts with Kling AI 3.0, and while it’s obviously not on the same level as Spielberg’s film, this clip shows how AI is getting closer and closer to true cinematic excellence.

One of the most intense experiences I remember in a movie theater was watching the Normandy landing in Saving Private Ryan. I wanted to recreate the moment of the landing crafts with Kling AI 3.0, and while it’s obviously not on the same level as Spielberg’s film, this clip shows how AI is getting closer and closer to true cinematic excellence.

OscarAI

13,304 görüntüleme • 5 ay önce

🔋 One more push ahead, and even the safe and cozy Yaniv can already be seen. Some starving howls are following along, closer and louder every second. The backpack is full of precious habar from a foray, though no breath to keep it further. Whoever was there knows… In moments like this, you should start to say goodbyes to the habar or your life, depending on one’s values. For that kind of mishap, experienced stalkers got an ace in the can, the same as 16 years ago. Reliable. Tasty. And refreshing, how it should be. Be NON STOP by nature, but keep a few in your stash. Non Stop🤝S.T.A.L.K.E.R. OFFICIAL — just like on the first journey, officially together again! #Stalker2 x #NonStopEnergy x #NonStoppable

🔋 One more push ahead, and even the safe and cozy Yaniv can already be seen. Some starving howls are following along, closer and louder every second. The backpack is full of precious habar from a foray, though no breath to keep it further. Whoever was there knows… In moments like this, you should start to say goodbyes to the habar or your life, depending on one’s values. For that kind of mishap, experienced stalkers got an ace in the can, the same as 16 years ago. Reliable. Tasty. And refreshing, how it should be. Be NON STOP by nature, but keep a few in your stash. Non Stop🤝S.T.A.L.K.E.R. OFFICIAL — just like on the first journey, officially together again! #Stalker2 x #NonStopEnergy x #NonStoppable

S.T.A.L.K.E.R. OFFICIAL

988,645 görüntüleme • 3 yıl önce

‼️🇺🇸 Two Turnin Two Burnin. USS Milius in Motion 🔥 The waves are rough yet this destroyer moves with steady force as DDG 69 USS Milius shows what it can do. It is a guided missile destroyer equipped with the Aegis system that tracks aircraft and missile threats with remarkable precision. It carries vertical launch cells for Tomahawk and Standard Missiles and uses a powerful five inch naval gun for surface engagements. Its advanced sensors and sonar give it strong reach against submarines, making it a fully capable multi mission warship.

‼️🇺🇸 Two Turnin Two Burnin. USS Milius in Motion 🔥 The waves are rough yet this destroyer moves with steady force as DDG 69 USS Milius shows what it can do. It is a guided missile destroyer equipped with the Aegis system that tracks aircraft and missile threats with remarkable precision. It carries vertical launch cells for Tomahawk and Standard Missiles and uses a powerful five inch naval gun for surface engagements. Its advanced sensors and sonar give it strong reach against submarines, making it a fully capable multi mission warship.

WAR

41,062 görüntüleme • 7 ay önce

Uranium, a silvery-gray radioactive metal, is found in Zamfara State, Nigeria, though no large-scale mining is currently in operation. In its natural form, uranium ore can appear black, yellow, or green, depending on its mineral composition. While weakly radioactive, uranium poses significant risks if inhaled, ingested, or improperly handled, as it emits alpha radiation and is chemically toxic to the kidneys. The greatest dangers come from uranium dust, radon gas exposure, and improper waste disposal, which can lead to environmental contamination and health hazards like lung cancer. Shockingly, in this a recent video, allegedly from Zamfara mines, it can be seen and heard how people handle uranium, completely unaware of the grave risks involved. In the video, it can be heard that one person recording was telling another called Yushau in Hausa about the quantity of the metal available (8 to 10 kilograms), further exposing the dangerous ignorance surrounding its handling. This reckless exposure highlights the urgent need for government intervention. This further highlights why the authorities must manage and handle the mining crisis in those locations to avoid exposing people to dangerous gasses that would continue to damage their organs. NB: As of February 20, 2025, the market price of uranium is roughly $143 (₦214, 500) per kilogram. (Source:

Uranium, a silvery-gray radioactive metal, is found in Zamfara State, Nigeria, though no large-scale mining is currently in operation. In its natural form, uranium ore can appear black, yellow, or green, depending on its mineral composition. While weakly radioactive, uranium poses significant risks if inhaled, ingested, or improperly handled, as it emits alpha radiation and is chemically toxic to the kidneys. The greatest dangers come from uranium dust, radon gas exposure, and improper waste disposal, which can lead to environmental contamination and health hazards like lung cancer. Shockingly, in this a recent video, allegedly from Zamfara mines, it can be seen and heard how people handle uranium, completely unaware of the grave risks involved. In the video, it can be heard that one person recording was telling another called Yushau in Hausa about the quantity of the metal available (8 to 10 kilograms), further exposing the dangerous ignorance surrounding its handling. This reckless exposure highlights the urgent need for government intervention. This further highlights why the authorities must manage and handle the mining crisis in those locations to avoid exposing people to dangerous gasses that would continue to damage their organs. NB: As of February 20, 2025, the market price of uranium is roughly $143 (₦214, 500) per kilogram. (Source:

Dr. Hidima

23,495 görüntüleme • 1 yıl önce