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the first songbird #basalganglia #brain connectome: -8,500 automated neuron reconstructions -20 million synapses -16 cell types

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Alessandro Crimi 🧠🧬🔬🩺( @alecrimi.bsky.social )

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13,795 просмотров • 9 месяцев назад •via X (Twitter)

#basalganglia#brain
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Since the '50 largest neurons' #connectome render with Amy Robinson Sterling FlyWire has made it's way around the world, I'm sharing an animated version. Including: Information flow from the ocelli, 50 largest #neurons, and a LOT of #synapses on one MASSIVE neuron. #neuroscience
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Since the '50 largest neurons' #connectome render with Amy Robinson Sterling FlyWire has made it's way around the world, I'm sharing an animated version. Including: Information flow from the ocelli, 50 largest #neurons, and a LOT of #synapses on one MASSIVE neuron. #neuroscience

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Over 50,000 annotations have been added to the connectome by the FlyWire community! This APL neuron, tagged by M. W. Pleijzier Zhihao Zheng, is 20x longer than a fly's whole body and is the longest cell in the brain. Proofread by labs of Greg Jefferis Murthy Lab Sebastian Seung
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Over 50,000 annotations have been added to the connectome by the FlyWire community! This APL neuron, tagged by M. W. Pleijzier Zhihao Zheng, is 20x longer than a fly's whole body and is the longest cell in the brain. Proofread by labs of Greg Jefferis Murthy Lab Sebastian Seung

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This might make you think twice next time you reach for the fly swatter. The whole brain wiring diagram of the fly! All 140,000 neurons and their 50M synapses are available to explore in Codex, the Connectome Data Explorer: #sfn23
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This might make you think twice next time you reach for the fly swatter. The whole brain wiring diagram of the fly! All 140,000 neurons and their 50M synapses are available to explore in Codex, the Connectome Data Explorer: #sfn23

FlyWire

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I’ve made this video as an intuition pump for the density of #synapses in the #brain. This volume ~ grain of sand, has >3.2 million synapses (orange cubes). Peeling them away leaves only inputs on 2 #neurons. Zooming in, we see the synapses localized to the dendritic spines. #b3d
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I’ve made this video as an intuition pump for the density of #synapses in the #brain. This volume ~ grain of sand, has >3.2 million synapses (orange cubes). Peeling them away leaves only inputs on 2 #neurons. Zooming in, we see the synapses localized to the dendritic spines. #b3d

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4 years. 250 people. 2.7 million edits to proofread 127,000 neurons. The fly connectome is here! Preprint: Neuronal wiring diagram of an adult brain Explore it in Codex:
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4 years. 250 people. 2.7 million edits to proofread 127,000 neurons. The fly connectome is here! Preprint: Neuronal wiring diagram of an adult brain Explore it in Codex:

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Max Hodak envisions a brain-computer interface inspired by Avatar: a living, high-bandwidth “13th cranial nerve.” Instead of implants, his team is grafting stem cell–derived neurons into the brain via hydrogel. A biological USB cable -- 100,000 electrodes, a billion synapses.
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Max Hodak envisions a brain-computer interface inspired by Avatar: a living, high-bandwidth “13th cranial nerve.” Instead of implants, his team is grafting stem cell–derived neurons into the brain via hydrogel. A biological USB cable -- 100,000 electrodes, a billion synapses.

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How do different brain cell types connect with each other? We're mapping the brain to learn more. In this video from our #ElectronMicroscopy team, we see how complex brain cells can be. #BrainAwarenessWeek
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How do different brain cell types connect with each other? We're mapping the brain to learn more. In this video from our #ElectronMicroscopy team, we see how complex brain cells can be. #BrainAwarenessWeek

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This is the first brain map showing how decisions are made. Each colored dot represents a neuron that is firing during the process.
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This is the first brain map showing how decisions are made. Each colored dot represents a neuron that is firing during the process.

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For the first time, scientists analysed the connectome for part of the brain in the common octopus involved in long-term memory. Here, they use #ElectronMicroscopy to trace the length of an axon micron by micron.
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For the first time, scientists analysed the connectome for part of the brain in the common octopus involved in long-term memory. Here, they use #ElectronMicroscopy to trace the length of an axon micron by micron.

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We've uploaded a fruit fly. We took the FlyWire connectome of the fruit fly brain, applied a simple neuron model (Philip Shiu Nature 2024) and used it to control a MuJoCo physics-simulated body, closing the loop from neural activation to action. A few things I want to say about what this means and where we're going at eon. 🧵

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