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⚡🎉 We are thrilled to introduce VORTEX, an AI-powered computational framework for predicting 3D Spatial Transcriptomics (ST) using 3D tissue images and minimal 2D ST! 🧬 By combining cutting-edge 3D non-destructive tissue imaging with AI, VORTEX imputes the 3D molecular landscape of large tissue samples in a cost-effective and...

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Faisal Mahmood

6,989 subscribers

17,991 次观看 • 1 年前 •via X (Twitter)

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Joe Yeong 的头像
Joe Yeong1 年前

hi Faisal, welcome to Asia in June. :) texted u in both twitter and Linkedin. :)

SCAI 的头像
SCAI1 年前

💡 Take your interventional cardiology career to the next level at SCAI 2025 Scientific Sessions. Join us on May 1-3, in Washington, D.C. Three days of innovative science, practical education, and world-class networking await you.🌟 Secure your spot today.

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DrNeil1 年前

I think there should be a artificial general intelligence medicine ai or branched or field based ai system which learn and self imporve.

相关视频

⚡️📣👇Tremendously excited to share our new Cell article, where we develop TriPath, a method for analyzing 3D pathology samples using weakly supervised AI. Article: TriPath enables 3D computational pathology via 3D multiple instance learning allowing AI models to capture intricate morphological details from pathology volumes. Code: Blog post: Tested on two different imaging modalities, and patient cohorts from two institutions. Our superstar Andrew H. Song put in a monumental effort of leading the study, in a fantastic collaboration with Jonathan Liu at University of Washington . Interesting aspects: - Utilizing the whole tissue volume and leveraging 3D deep learning enable superior risk prediction performance compared to 2D deep learning baselines based on a few sampled tissue sections that emulate standard clinical practice. This indicates TriPath can harness additional information provided by 3D tissue morphology. - The performance is also superior to clinical baselines from a reader study that involved six expert pathologists. - The morphologically heterogeneous tissue volume could lead to opposing patient-level outcome predictions, dependent on which portion of the tissue volume is used. This concurs with current clinical literature warning that tissue sampling bias can lead to misdiagnosis. Some limitations: - While the 3D pathology cohort size is unprecedented, it is smaller than typical 2D pathology cohorts. Further large-scale studies will be required for validation. Nevertheless, we believe that this study will initiate a positive cycle, encouraging academic institutions and pharmaceutical companies to contribute large banks of human tissue blocks with paired clinical outcomes, thus speeding up advancements in 3D computational pathology. Concluding insights: We believe that 3D pathology is just around the corner - It has the huge potential to not only augment/improve the current clinical practice centered around 2D examination of human tissue, but also help reveal novel biomarkers for prognosis and therapeutic response.. Harvard Medical School Harvard Data Science Initiative Mass General Brigham Broad Institute
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⚡️📣👇Tremendously excited to share our new Cell article, where we develop TriPath, a method for analyzing 3D pathology samples using weakly supervised AI. Article: TriPath enables 3D computational pathology via 3D multiple instance learning allowing AI models to capture intricate morphological details from pathology volumes. Code: Blog post: Tested on two different imaging modalities, and patient cohorts from two institutions. Our superstar Andrew H. Song put in a monumental effort of leading the study, in a fantastic collaboration with Jonathan Liu at University of Washington . Interesting aspects: - Utilizing the whole tissue volume and leveraging 3D deep learning enable superior risk prediction performance compared to 2D deep learning baselines based on a few sampled tissue sections that emulate standard clinical practice. This indicates TriPath can harness additional information provided by 3D tissue morphology. - The performance is also superior to clinical baselines from a reader study that involved six expert pathologists. - The morphologically heterogeneous tissue volume could lead to opposing patient-level outcome predictions, dependent on which portion of the tissue volume is used. This concurs with current clinical literature warning that tissue sampling bias can lead to misdiagnosis. Some limitations: - While the 3D pathology cohort size is unprecedented, it is smaller than typical 2D pathology cohorts. Further large-scale studies will be required for validation. Nevertheless, we believe that this study will initiate a positive cycle, encouraging academic institutions and pharmaceutical companies to contribute large banks of human tissue blocks with paired clinical outcomes, thus speeding up advancements in 3D computational pathology. Concluding insights: We believe that 3D pathology is just around the corner - It has the huge potential to not only augment/improve the current clinical practice centered around 2D examination of human tissue, but also help reveal novel biomarkers for prognosis and therapeutic response.. Harvard Medical School Harvard Data Science Initiative Mass General Brigham Broad Institute

Faisal Mahmood

65,520 次观看 • 2 年前

LLaVA-3D A Simple yet Effective Pathway to Empowering LMMs with 3D-awareness Recent advancements in Large Multimodal Models (LMMs) have greatly enhanced their proficiency in 2D visual understanding tasks, enabling them to effectively process and understand images and videos. However, the development of LMMs with 3D-awareness for 3D scene understanding has been hindered by the lack of large-scale 3D vision-language datasets and powerful 3D encoders. In this paper, we introduce a simple yet effective framework called LLaVA-3D. Leveraging the strong 2D understanding priors from LLaVA, our LLaVA-3D efficiently adapts LLaVA for 3D scene understanding without compromising 2D understanding capabilities. To achieve this, we employ a simple yet effective representation, 3D Patch, which connects 2D CLIP patch features with their corresponding positions in 3D space. By integrating the 3D Patches into 2D LMMs and employing joint 2D and 3D vision-language instruction tuning, we establish a unified architecture for both 2D image understanding and 3D scene understanding. Experimental results show that LLaVA-3D converges 3.5x faster than existing 3D LMMs when trained on 3D vision-language datasets. Moreover, LLaVA-3D not only achieves state-of-the-art performance across various 3D tasks but also maintains comparable 2D image understanding and vision-language conversation capabilities with LLaVA.
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LLaVA-3D A Simple yet Effective Pathway to Empowering LMMs with 3D-awareness Recent advancements in Large Multimodal Models (LMMs) have greatly enhanced their proficiency in 2D visual understanding tasks, enabling them to effectively process and understand images and videos. However, the development of LMMs with 3D-awareness for 3D scene understanding has been hindered by the lack of large-scale 3D vision-language datasets and powerful 3D encoders. In this paper, we introduce a simple yet effective framework called LLaVA-3D. Leveraging the strong 2D understanding priors from LLaVA, our LLaVA-3D efficiently adapts LLaVA for 3D scene understanding without compromising 2D understanding capabilities. To achieve this, we employ a simple yet effective representation, 3D Patch, which connects 2D CLIP patch features with their corresponding positions in 3D space. By integrating the 3D Patches into 2D LMMs and employing joint 2D and 3D vision-language instruction tuning, we establish a unified architecture for both 2D image understanding and 3D scene understanding. Experimental results show that LLaVA-3D converges 3.5x faster than existing 3D LMMs when trained on 3D vision-language datasets. Moreover, LLaVA-3D not only achieves state-of-the-art performance across various 3D tasks but also maintains comparable 2D image understanding and vision-language conversation capabilities with LLaVA.

AK

41,713 次观看 • 1 年前

3D-LLM: Injecting the 3D World into Large Language Models paper page: Large language models (LLMs) and Vision-Language Models (VLMs) have been proven to excel at multiple tasks, such as commonsense reasoning. Powerful as these models can be, they are not grounded in the 3D physical world, which involves richer concepts such as spatial relationships, affordances, physics, layout, and so on. In this work, we propose to inject the 3D world into large language models and introduce a whole new family of 3D-LLMs. Specifically, 3D-LLMs can take 3D point clouds and their features as input and perform a diverse set of 3D-related tasks, including captioning, dense captioning, 3D question answering, task decomposition, 3D grounding, 3D-assisted dialog, navigation, and so on. Using three types of prompting mechanisms that we design, we are able to collect over 300k 3D-language data covering these tasks. To efficiently train 3D-LLMs, we first utilize a 3D feature extractor that obtains 3D features from rendered multi- view images. Then, we use 2D VLMs as our backbones to train our 3D-LLMs. By introducing a 3D localization mechanism, 3D-LLMs can better capture 3D spatial information. Experiments on ScanQA show that our model outperforms state-of-the-art baselines by a large margin (e.g., the BLEU-1 score surpasses state-of-the-art score by 9%). Furthermore, experiments on our held-in datasets for 3D captioning, task composition, and 3D-assisted dialogue show that our model outperforms 2D VLMs. Qualitative examples also show that our model could perform more tasks beyond the scope of existing LLMs and VLMs.
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3D-LLM: Injecting the 3D World into Large Language Models paper page: Large language models (LLMs) and Vision-Language Models (VLMs) have been proven to excel at multiple tasks, such as commonsense reasoning. Powerful as these models can be, they are not grounded in the 3D physical world, which involves richer concepts such as spatial relationships, affordances, physics, layout, and so on. In this work, we propose to inject the 3D world into large language models and introduce a whole new family of 3D-LLMs. Specifically, 3D-LLMs can take 3D point clouds and their features as input and perform a diverse set of 3D-related tasks, including captioning, dense captioning, 3D question answering, task decomposition, 3D grounding, 3D-assisted dialog, navigation, and so on. Using three types of prompting mechanisms that we design, we are able to collect over 300k 3D-language data covering these tasks. To efficiently train 3D-LLMs, we first utilize a 3D feature extractor that obtains 3D features from rendered multi- view images. Then, we use 2D VLMs as our backbones to train our 3D-LLMs. By introducing a 3D localization mechanism, 3D-LLMs can better capture 3D spatial information. Experiments on ScanQA show that our model outperforms state-of-the-art baselines by a large margin (e.g., the BLEU-1 score surpasses state-of-the-art score by 9%). Furthermore, experiments on our held-in datasets for 3D captioning, task composition, and 3D-assisted dialogue show that our model outperforms 2D VLMs. Qualitative examples also show that our model could perform more tasks beyond the scope of existing LLMs and VLMs.

AK

249,572 次观看 • 2 年前

Magic123: One Image to High-Quality 3D Object Generation Using Both 2D and 3D Diffusion Priors paper page: present Magic123, a two-stage coarse-to-fine approach for high-quality, textured 3D meshes generation from a single unposed image in the wild using both2D and 3D priors. In the first stage, we optimize a neural radiance field to produce a coarse geometry. In the second stage, we adopt a memory-efficient differentiable mesh representation to yield a high-resolution mesh with a visually appealing texture. In both stages, the 3D content is learned through reference view supervision and novel views guided by a combination of 2D and 3D diffusion priors. We introduce a single trade-off parameter between the 2D and 3D priors to control exploration (more imaginative) and exploitation (more precise) of the generated geometry. Additionally, we employ textual inversion and monocular depth regularization to encourage consistent appearances across views and to prevent degenerate solutions, respectively. Magic123 demonstrates a significant improvement over previous image-to-3D techniques, as validated through extensive experiments on synthetic benchmarks and diverse real-world images.
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Magic123: One Image to High-Quality 3D Object Generation Using Both 2D and 3D Diffusion Priors paper page: present Magic123, a two-stage coarse-to-fine approach for high-quality, textured 3D meshes generation from a single unposed image in the wild using both2D and 3D priors. In the first stage, we optimize a neural radiance field to produce a coarse geometry. In the second stage, we adopt a memory-efficient differentiable mesh representation to yield a high-resolution mesh with a visually appealing texture. In both stages, the 3D content is learned through reference view supervision and novel views guided by a combination of 2D and 3D diffusion priors. We introduce a single trade-off parameter between the 2D and 3D priors to control exploration (more imaginative) and exploitation (more precise) of the generated geometry. Additionally, we employ textual inversion and monocular depth regularization to encourage consistent appearances across views and to prevent degenerate solutions, respectively. Magic123 demonstrates a significant improvement over previous image-to-3D techniques, as validated through extensive experiments on synthetic benchmarks and diverse real-world images.

AK

305,643 次观看 • 3 年前

CODA day! The CODA team at Johns Hopkins University maps pancreatic precursor lesions in 3D and at single-cell level. First 3D spatial genomic maps of large tissue samples. A human pancreas contains a staggering ~1000 lesions, some showing multifocality. Here:
0:47

CODA day! The CODA team at Johns Hopkins University maps pancreatic precursor lesions in 3D and at single-cell level. First 3D spatial genomic maps of large tissue samples. A human pancreas contains a staggering ~1000 lesions, some showing multifocality. Here:

Denis Wirtz

74,271 次观看 • 2 年前

🧬 Take a look inside a 3D tissue bioprinting lab! NIH postdoctoral fellow Dr. Cristina Antich Acedo demonstrates how cutting-edge bioprinting can recreate human tissue structure. By combining different cell types and biomaterials, researchers can mimic real biological environments with precision. 🔬 This technology helps accelerate the path from discovery to treatment: • More predictive preclinical models • Reduced reliance on animal testing • Faster, more accurate drug development
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🧬 Take a look inside a 3D tissue bioprinting lab! NIH postdoctoral fellow Dr. Cristina Antich Acedo demonstrates how cutting-edge bioprinting can recreate human tissue structure. By combining different cell types and biomaterials, researchers can mimic real biological environments with precision. 🔬 This technology helps accelerate the path from discovery to treatment: • More predictive preclinical models • Reduced reliance on animal testing • Faster, more accurate drug development

NIH

14,475 次观看 • 1 个月前

The challenge of creating this scene was from a 3D environment to a 2D painted environment. We used the character to bait-and-switch out the backgrounds. #2d #3d #animation
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The challenge of creating this scene was from a 3D environment to a 2D painted environment. We used the character to bait-and-switch out the backgrounds. #2d #3d #animation

THE LINE

696,502 次观看 • 3 年前

Discover the future of 3D-omics! Our perspective aritcle explores how tissue clearing and AI with single-cell omics could revolutionize understanding of entire organs & organisms. Read the full article:
0:58

Discover the future of 3D-omics! Our perspective aritcle explores how tissue clearing and AI with single-cell omics could revolutionize understanding of entire organs & organisms. Read the full article:

Ali Max Erturk

38,253 次观看 • 1 年前

Semantically annotating 3D gaussian splats on the fly using gemini 3.1 + sparkjs 1. Load any 3D scene and hit scan 2. Get 2D detections from VLM 3. Cluster outputs & project into 3D world space 4. Save as a persistent 3D semantic layer Inspired by Alexander Chen's experiments with gemini visual intelligence. Just had to try to lift it from 2D to 3D!
0:21

Semantically annotating 3D gaussian splats on the fly using gemini 3.1 + sparkjs 1. Load any 3D scene and hit scan 2. Get 2D detections from VLM 3. Cluster outputs & project into 3D world space 4. Save as a persistent 3D semantic layer Inspired by Alexander Chen's experiments with gemini visual intelligence. Just had to try to lift it from 2D to 3D!

Bilawal Sidhu

56,642 次观看 • 1 个月前

Combining 2D and 3D in After Effects. In Foldspace, not every surface needs to be bent. Keep one flat for 2D artwork, and let the others exist in 3D space. This allows you to combine 2D and 3D objects in a single animation with no masks or tricks needed.
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Combining 2D and 3D in After Effects. In Foldspace, not every surface needs to be bent. Keep one flat for 2D artwork, and let the others exist in 3D space. This allows you to combine 2D and 3D objects in a single animation with no masks or tricks needed.

Motion Princess

21,666 次观看 • 3 个月前

🚀 Our NeurIPS '24 work, Large Spatial Model (LSM), is here! LSM performs semantic 3D reconstruction in just 0.1s, processing unposed data via feed-forward 3D reconstruction. 👉It leverages large-scale 3D datasets with minimal annotations, defining a 3D latent space. We are continuously exploring how this explicit 3D representation can further enhance reasoning and robotic learning. 🔗 Try our online Gradio demo with your own data at #NeurIPS2024 #3DReconstruction
0:23

🚀 Our NeurIPS '24 work, Large Spatial Model (LSM), is here! LSM performs semantic 3D reconstruction in just 0.1s, processing unposed data via feed-forward 3D reconstruction. 👉It leverages large-scale 3D datasets with minimal annotations, defining a 3D latent space. We are continuously exploring how this explicit 3D representation can further enhance reasoning and robotic learning. 🔗 Try our online Gradio demo with your own data at #NeurIPS2024 #3DReconstruction

Zhiwen(Aaron) Fan

43,871 次观看 • 1 年前

We are thrilled to share that our first paper from my new lab, Spateo ( for spatiotemporal modeling of molecular holograms, is now online in Cell: Spateo is a comprehensive analytical framework for 3D whole-embryo spatiotemporal modeling. Its advanced features include: • 3D alignment and reconstruction at the whole-mouse-embryo scale (see the animation). • 3D spatial domain digitization and cell-cell communication analysis to understand spatial gene expression gradients and both inter- and intracellular communication. • 3D morphometric and volumetric analyses along with 3D morphogenesis vector field modeling to quantify dynamics such as surface area, volume, and cell density across organs, and to dissect the interplay between morphogenesis factors and cell migration. • A “Google Earth”-like browser, Spateo-viewer ( and for interactive and intuitive exploration of 3D spatial data. • Additional features, such as RNA signal-based single-cell segmentation. We are also honored that Nature “News and Views” has highlighted this work as well: This is really an amazing outcome after two years' heroic revision process that rewrite the entire paper using a new data ( for whole mouse embryos.
1:24

We are thrilled to share that our first paper from my new lab, Spateo ( for spatiotemporal modeling of molecular holograms, is now online in Cell: Spateo is a comprehensive analytical framework for 3D whole-embryo spatiotemporal modeling. Its advanced features include: • 3D alignment and reconstruction at the whole-mouse-embryo scale (see the animation). • 3D spatial domain digitization and cell-cell communication analysis to understand spatial gene expression gradients and both inter- and intracellular communication. • 3D morphometric and volumetric analyses along with 3D morphogenesis vector field modeling to quantify dynamics such as surface area, volume, and cell density across organs, and to dissect the interplay between morphogenesis factors and cell migration. • A “Google Earth”-like browser, Spateo-viewer ( and for interactive and intuitive exploration of 3D spatial data. • Additional features, such as RNA signal-based single-cell segmentation. We are also honored that Nature “News and Views” has highlighted this work as well: This is really an amazing outcome after two years' heroic revision process that rewrite the entire paper using a new data ( for whole mouse embryos.

evo-devo

58,300 次观看 • 1 年前

📢WorldAgents: 3D worlds only from 2D image models - without any training! We propose an agentic approach with a Director (VLM) to plan the scene, a Generator (Flux or NanoBanana) for new views, and a Verifier (VLM) for selection / 3D consistency. -> High-fidelity 3D worlds from a single text prompt. What's remarkable: our agents find consistent views from 2D image models to obtain 3D-consistent worlds; this shows that image models contain world priors - agents just need to find them! Great work by Ziya Erkoç Angela Dai
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📢WorldAgents: 3D worlds only from 2D image models - without any training! We propose an agentic approach with a Director (VLM) to plan the scene, a Generator (Flux or NanoBanana) for new views, and a Verifier (VLM) for selection / 3D consistency. -> High-fidelity 3D worlds from a single text prompt. What's remarkable: our agents find consistent views from 2D image models to obtain 3D-consistent worlds; this shows that image models contain world priors - agents just need to find them! Great work by Ziya Erkoç Angela Dai

Matthias Niessner

18,923 次观看 • 3 个月前

I dramatically shifted my stream's perspective from 2D to 3D. Chat thought we were starting the stream in our standard 2D overlay, until I zoomed out to reveal my new 3D vtuber model.
1:16

I dramatically shifted my stream's perspective from 2D to 3D. Chat thought we were starting the stream in our standard 2D overlay, until I zoomed out to reveal my new 3D vtuber model.

shindigs

89,867 次观看 • 1 年前

3D for Hana is here. The first canvas that combines 3D and 2D in real-time. Convert any shape to a 3D model in a non-destructive process. All systems (vectors, booleans, layouts, events, etc.) work together.
1:08

3D for Hana is here. The first canvas that combines 3D and 2D in real-time. Convert any shape to a 3D model in a non-destructive process. All systems (vectors, booleans, layouts, events, etc.) work together.

Spline

114,457 次观看 • 6 个月前

You can build your 3D models directly from a prompt into Claude code. All thanks to this beautiful python project, build123 a parametric modeling framework for 2D and 3D CAD. It is built on the Open Cascade geometric kernel and it is suitable for 3D printing.
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You can build your 3D models directly from a prompt into Claude code. All thanks to this beautiful python project, build123 a parametric modeling framework for 2D and 3D CAD. It is built on the Open Cascade geometric kernel and it is suitable for 3D printing.

Marco Franzon

20,777 次观看 • 3 个月前

🔥 Introducing MVLift: Generate realistic 3D motion without any 3D training data - just using 2D poses from monocular videos! Applicable to human motion, human-object interaction & animal motion. Joint work w/ Jiajun Wu & Karen 💡 How? We reformulate 3D motion estimation as generating consistent multi-view 2D pose sequences. Our framework uses 2D motion diffusion to progressively establish multi-view consistency, requiring only single-view 2D pose sequences for training. Project: Video with demonstration: Paper:
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🔥 Introducing MVLift: Generate realistic 3D motion without any 3D training data - just using 2D poses from monocular videos! Applicable to human motion, human-object interaction & animal motion. Joint work w/ Jiajun Wu & Karen 💡 How? We reformulate 3D motion estimation as generating consistent multi-view 2D pose sequences. Our framework uses 2D motion diffusion to progressively establish multi-view consistency, requiring only single-view 2D pose sequences for training. Project: Video with demonstration: Paper:

Jiaman Li

15,875 次观看 • 1 年前

New preprint from our group, led by Lissa Ventura Antunes, explores structural changes in arterioles with cerebral amyloid angiopathy. Lissa is a master of quantitative 3D microscopy. In this clip, healthy tissue is first, then two cases with CAA. @VUMCneurology Vanderbilt University Medical Center
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New preprint from our group, led by Lissa Ventura Antunes, explores structural changes in arterioles with cerebral amyloid angiopathy. Lissa is a master of quantitative 3D microscopy. In this clip, healthy tissue is first, then two cases with CAA. @VUMCneurology Vanderbilt University Medical Center

Matthew Schrag

11,966 次观看 • 2 年前

Another AI Experiment. Using SHARP, Apple's ML framework - magical stuff. 2D Images to 3D Gaussian splats. Plotted and flown in Three.js
0:57

Another AI Experiment. Using SHARP, Apple's ML framework - magical stuff. 2D Images to 3D Gaussian splats. Plotted and flown in Three.js

M. Ali Kapadia

26,886 次观看 • 4 个月前

Polishing my shader to auto-convert 2D images to 3D (Texture + 3D entirely created from scratch in 5 minutes) #Midjourney #AIart #AIイラスト #gamedev #StableDiffussion
0:22

Polishing my shader to auto-convert 2D images to 3D (Texture + 3D entirely created from scratch in 5 minutes) #Midjourney #AIart #AIイラスト #gamedev #StableDiffussion

Cristian Peñas ░░░░░░░░

469,546 次观看 • 3 年前