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David Sinclair does one meal a day at 6pm, and feels sharper, less bloated, sleeps better, and concentrates more clearly. No breakfast. No lunch. Just coffee, tea, and water. He says a little hunger stress flips on your body’s ancient anti-aging defenses. Give it two weeks and your system... show more

Camus

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65,568 views • 2 months ago •via X (Twitter)

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David Sinclair’s #1 anti-aging hack: Skip a meal or two every day. He’s on one-meal-a-day and says he got his 20-year-old body back, feels sharper, sleeps better, and has steady energy. Fasting flips on the same longevity genes (like sirtuins) our ancestors used to survive hard times. His tip: Don’t go cold turkey. Give it at least two weeks, your body adapts and the hunger fades. Multiple studies (including human trials) show time-restricted eating and intermittent fasting improve metabolic health, insulin sensitivity, reduce inflammation, and activate cellular repair (autophagy). Animal studies link it to longer lifespan, while human data supports better markers of biological age. What’s your take, could skipping one meal a day be one of the highest-leverage things you can do for longevity?

David Sinclair’s #1 anti-aging hack: Skip a meal or two every day. He’s on one-meal-a-day and says he got his 20-year-old body back, feels sharper, sleeps better, and has steady energy. Fasting flips on the same longevity genes (like sirtuins) our ancestors used to survive hard times. His tip: Don’t go cold turkey. Give it at least two weeks, your body adapts and the hunger fades. Multiple studies (including human trials) show time-restricted eating and intermittent fasting improve metabolic health, insulin sensitivity, reduce inflammation, and activate cellular repair (autophagy). Animal studies link it to longer lifespan, while human data supports better markers of biological age. What’s your take, could skipping one meal a day be one of the highest-leverage things you can do for longevity?

Camus

42,824 views • 2 months ago

David Sinclair explained why one meal a day might beat constant snacking. Our bodies evolved for periods of hunger in the wild. Constant eating tells your system “everything’s fine, no need to fight aging.” But going longer without food flips on longevity genes that repair and protect you. It’s one of those simple ideas that feels counterintuitive at first but makes a lot of sense when you think about human history. In a world of endless food availability, strategically building in hunger could be one of the most powerful tools we have for long-term health and resilience. What’s your experience with one meal a day or extended fasting?

David Sinclair explained why one meal a day might beat constant snacking. Our bodies evolved for periods of hunger in the wild. Constant eating tells your system “everything’s fine, no need to fight aging.” But going longer without food flips on longevity genes that repair and protect you. It’s one of those simple ideas that feels counterintuitive at first but makes a lot of sense when you think about human history. In a world of endless food availability, strategically building in hunger could be one of the most powerful tools we have for long-term health and resilience. What’s your experience with one meal a day or extended fasting?

Camus

81,497 views • 2 months ago

David Sinclair’s 43-second longevity hack (no breakfast, no lunch): The secret isn’t starving — it’s hormesis: A little controlled stress (hunger, cold, heat, exercise) tricks your body into thinking “I might die” → activates powerful anti-aging defenses that have been hardwired for thousands of years. Eating less (without malnutrition) flips the switch. 43-sec clip — why skipping meals might be the ultimate longevity cheat code 👇 Who’s already practicing intermittent fasting / hormesis?

David Sinclair’s 43-second longevity hack (no breakfast, no lunch): The secret isn’t starving — it’s hormesis: A little controlled stress (hunger, cold, heat, exercise) tricks your body into thinking “I might die” → activates powerful anti-aging defenses that have been hardwired for thousands of years. Eating less (without malnutrition) flips the switch. 43-sec clip — why skipping meals might be the ultimate longevity cheat code 👇 Who’s already practicing intermittent fasting / hormesis?

Camus

33,348 views • 7 months ago

Joe Rogan asked David Sinclair: If one meal a day is so effective, why not just eat smaller meals multiple times instead? Sinclair’s answer cuts deep: Our bodies evolved over millions of years in environments full of adversity — hunger, scarcity, survival. We’ve removed that stress because it feels good, but we actually need it. When you fast, even briefly, your body flips on “adversity response” genes — what Sinclair calls longevity genes. These ramp up repair, resilience, and disease defense. Eat constantly (breakfast as the “most important meal,” snacks all day), and your body thinks: “I just killed a mammoth. No threats here. Time to reproduce, not invest in long-term survival.” Constant eating signals safety. Periodic hunger signals: fight harder, repair better, age slower. A concise, science-backed reminder that comfort might be quietly working against us. What part of this evolutionary perspective on fasting and longevity hits you hardest — the role of hormesis/adversity, or how modern eating habits might be quietly undermining resilience?

Joe Rogan asked David Sinclair: If one meal a day is so effective, why not just eat smaller meals multiple times instead? Sinclair’s answer cuts deep: Our bodies evolved over millions of years in environments full of adversity — hunger, scarcity, survival. We’ve removed that stress because it feels good, but we actually need it. When you fast, even briefly, your body flips on “adversity response” genes — what Sinclair calls longevity genes. These ramp up repair, resilience, and disease defense. Eat constantly (breakfast as the “most important meal,” snacks all day), and your body thinks: “I just killed a mammoth. No threats here. Time to reproduce, not invest in long-term survival.” Constant eating signals safety. Periodic hunger signals: fight harder, repair better, age slower. A concise, science-backed reminder that comfort might be quietly working against us. What part of this evolutionary perspective on fasting and longevity hits you hardest — the role of hormesis/adversity, or how modern eating habits might be quietly undermining resilience?

Camus

484,467 views • 4 months ago

A Harvard professor who's studied aging for 30 years says one of the most powerful longevity tools on Earth is free. Fasting. David Sinclair explained what happens at the cellular level when you stop eating food for long periods of time: Your body has proteins called sirtuins. They're the conductors of your cellular orchestra - telling each gene when to turn on and off, keeping every cell's identity intact. But sirtuins need fuel called NAD to function. By age 50, your NAD levels drop by HALF. Your conductors are running on empty. Your cells start losing their identity. Fasting raises NAD back up. It reactivates the sirtuins and preserves the epigenome. Sinclair mentions it's only useful if you're already meeting nutrient and micronutrient intake as well. He himself skips breakfast daily and tries to go until late afternoon before eating. Once a month, he fasts for 3 full days because deep cellular recycling - called chaperone-mediated autophagy - only kicks in after about 2 and a half to 3 days. He called three meals a day "craziness" and said the idea that breakfast is the most important meal of the day was "marketing from the early 20th century" by cereal companies. Fasting is just one of the strategies he uses for optimal health. — David Sinclair

A Harvard professor who's studied aging for 30 years says one of the most powerful longevity tools on Earth is free. Fasting. David Sinclair explained what happens at the cellular level when you stop eating food for long periods of time: Your body has proteins called sirtuins. They're the conductors of your cellular orchestra - telling each gene when to turn on and off, keeping every cell's identity intact. But sirtuins need fuel called NAD to function. By age 50, your NAD levels drop by HALF. Your conductors are running on empty. Your cells start losing their identity. Fasting raises NAD back up. It reactivates the sirtuins and preserves the epigenome. Sinclair mentions it's only useful if you're already meeting nutrient and micronutrient intake as well. He himself skips breakfast daily and tries to go until late afternoon before eating. Once a month, he fasts for 3 full days because deep cellular recycling - called chaperone-mediated autophagy - only kicks in after about 2 and a half to 3 days. He called three meals a day "craziness" and said the idea that breakfast is the most important meal of the day was "marketing from the early 20th century" by cereal companies. Fasting is just one of the strategies he uses for optimal health. — David Sinclair

John Cumbers

231,590 views • 4 months ago

David Sinclair said: "You can reverse aging by 75% in 6 weeks… by reinstalling the "software" of the body so that it's young again." This idea sprouted when he proved in his first experiment that you can accelerate aging in mice: "We took two mice born on the same day—same age, same genetics. We 'scratched the CD' of one mouse, corrupting its software and accelerating its aging. The result was dramatic. One looked far older than its brother." He believed if you can give aging, you can also take it away. Tomorrow, I'll share his experiment on how he reversed aging in mice (and then Monkeys). — David Sinclair

David Sinclair said: "You can reverse aging by 75% in 6 weeks… by reinstalling the "software" of the body so that it's young again." This idea sprouted when he proved in his first experiment that you can accelerate aging in mice: "We took two mice born on the same day—same age, same genetics. We 'scratched the CD' of one mouse, corrupting its software and accelerating its aging. The result was dramatic. One looked far older than its brother." He believed if you can give aging, you can also take it away. Tomorrow, I'll share his experiment on how he reversed aging in mice (and then Monkeys). — David Sinclair

Goku

985,946 views • 5 months ago

David Sinclair said: "You can reverse aging by 75% in 6 weeks… by reinstalling the "software" of the body so that it's young again." This idea sprouted when he proved in his first experiment that you can accelerate aging in mice: "We took two mice born on the same day—same age, same genetics. We "scratched the CD" of one mouse, corrupting its software and accelerating its aging. The result was dramatic. One looked far older than its brother." He believed if you can give aging, you can also take it away. Tomorrow, I'll share his experiment on how he reversed aging in mice (and then Monkeys). — David Sinclair

David Sinclair said: "You can reverse aging by 75% in 6 weeks… by reinstalling the "software" of the body so that it's young again." This idea sprouted when he proved in his first experiment that you can accelerate aging in mice: "We took two mice born on the same day—same age, same genetics. We "scratched the CD" of one mouse, corrupting its software and accelerating its aging. The result was dramatic. One looked far older than its brother." He believed if you can give aging, you can also take it away. Tomorrow, I'll share his experiment on how he reversed aging in mice (and then Monkeys). — David Sinclair

John Cumbers

417,802 views • 5 months ago

Walmart is selling a whole rotisserie chicken plus two large sides for just $9.97. It comes with a full chicken, a big portion of mac and cheese, and mashed potatoes — all packaged and ready to heat up. For under $10, this is one of the better complete meal deals I’ve seen in a while. I would totally grab this meal, would you?

Walmart is selling a whole rotisserie chicken plus two large sides for just $9.97. It comes with a full chicken, a big portion of mac and cheese, and mashed potatoes — all packaged and ready to heat up. For under $10, this is one of the better complete meal deals I’ve seen in a while. I would totally grab this meal, would you?

End3of6Days9 (Helen) 🇺🇸

21,264 views • 2 months ago

Tim Robbins reveals he went 14 straight days without a single bite of food, lost 25 pounds, and unlocked total mental clarity "I just did a cleanse... one of those master cleanses. I just did 14 days on where you don't eat a thing for 14 days, and it's amazing how great you feel at the end of it." "14 whole days. No food at all?" "No food at all. No... It's lemon juice, cayenne pepper, and maple syrup, and that'll get you through the day. And then every morning you're doing a purge, right? So you're cleaning all the poisons out." "14 days is a long time with no food." "It is." "What was the first thing you ate when it was over?" "You got to ease your way back in. Like clear broth first, then soups, then vegetables... about a week re-entry." "Do you experience mental clarity when you do that?" "Total mental clarity. First three days are tough, but once you get past the third day, your energy level is constant throughout the day and you can work. I play sports with it..." "How do you decide when to do it?" "Usually when you've been a little indulgent and you're not feeling too good... and you put on a little weight." "You must lose a ton of weight doing that. How much have you lost doing 14 days?" "25 pounds. About two a day." "And then your body's running completely on ketones, right? Because your body's running on fat... your mental clarity is just so much better. Everything just runs smooth. Flat energy throughout the day, no crashing after a big meal." "And you sleep less, too. You need less sleep for some reason." "Also, I think it's probably good to give your digestive system a little break, too. Just let it relax."

Tim Robbins reveals he went 14 straight days without a single bite of food, lost 25 pounds, and unlocked total mental clarity "I just did a cleanse... one of those master cleanses. I just did 14 days on where you don't eat a thing for 14 days, and it's amazing how great you feel at the end of it." "14 whole days. No food at all?" "No food at all. No... It's lemon juice, cayenne pepper, and maple syrup, and that'll get you through the day. And then every morning you're doing a purge, right? So you're cleaning all the poisons out." "14 days is a long time with no food." "It is." "What was the first thing you ate when it was over?" "You got to ease your way back in. Like clear broth first, then soups, then vegetables... about a week re-entry." "Do you experience mental clarity when you do that?" "Total mental clarity. First three days are tough, but once you get past the third day, your energy level is constant throughout the day and you can work. I play sports with it..." "How do you decide when to do it?" "Usually when you've been a little indulgent and you're not feeling too good... and you put on a little weight." "You must lose a ton of weight doing that. How much have you lost doing 14 days?" "25 pounds. About two a day." "And then your body's running completely on ketones, right? Because your body's running on fat... your mental clarity is just so much better. Everything just runs smooth. Flat energy throughout the day, no crashing after a big meal." "And you sleep less, too. You need less sleep for some reason." "Also, I think it's probably good to give your digestive system a little break, too. Just let it relax."

Nichole

2,664,181 views • 25 days ago

A teacher pulled a parent aside after just two weeks of clean school lunches and said, "I have never, ever had the kids with this amount of attention in the afternoon after lunch." Two weeks. That's all it took to see the difference. 400,000 people signed a petition and showed up at Kellogg's front door to deliver it. Parents are testing their kids' food. Researchers are connecting the dots between what's on the plate and what's happening in the classroom, the doctor's office, and the gut. 85 chemicals still in the American food supply have already been banned everywhere else. The gaslighting campaign is ending. One meal at a time, one family at a time, one generation at a time. Go back to what your great-great-grandmother was serving for dinner. You are creating your culture and your legacy by the foods you choose to eat. Part II of Jefferey Jaxen Investigates: The Great American Food Fight is streaming NOW on HighWire+. Don't miss it.

A teacher pulled a parent aside after just two weeks of clean school lunches and said, "I have never, ever had the kids with this amount of attention in the afternoon after lunch." Two weeks. That's all it took to see the difference. 400,000 people signed a petition and showed up at Kellogg's front door to deliver it. Parents are testing their kids' food. Researchers are connecting the dots between what's on the plate and what's happening in the classroom, the doctor's office, and the gut. 85 chemicals still in the American food supply have already been banned everywhere else. The gaslighting campaign is ending. One meal at a time, one family at a time, one generation at a time. Go back to what your great-great-grandmother was serving for dinner. You are creating your culture and your legacy by the foods you choose to eat. Part II of Jefferey Jaxen Investigates: The Great American Food Fight is streaming NOW on HighWire+. Don't miss it.

The HighWire

13,427 views • 5 months ago

Bryan Johnson explains why cheat meal is the WORST idea in history “Food is the most complicated. Food is where we go to soothe ourselves, to do a kind of self therapy. Try to start by having a bit more of the good things for you and a few less of the bad things. Slowly work your way into it, because radical change is hard for a lot of people” “Have in the back of your mind a rule that you will never eat fast food ever again. None is better than some. The idea of a cheat meal is the worst idea in history. Don’t do cheat days, don’t do cheat meals, don’t do cheat weeks. Don’t cheat on anything”

Bryan Johnson explains why cheat meal is the WORST idea in history “Food is the most complicated. Food is where we go to soothe ourselves, to do a kind of self therapy. Try to start by having a bit more of the good things for you and a few less of the bad things. Slowly work your way into it, because radical change is hard for a lot of people” “Have in the back of your mind a rule that you will never eat fast food ever again. None is better than some. The idea of a cheat meal is the worst idea in history. Don’t do cheat days, don’t do cheat meals, don’t do cheat weeks. Don’t cheat on anything”

Mikli

90,736 views • 5 months ago

He likes going on little walks. He sleeps for 23 hours a day. His body is decompressing after years of poor health and no human touch. You can see him taking it all in and really enjoying it. (6/7)

He likes going on little walks. He sleeps for 23 hours a day. His body is decompressing after years of poor health and no human touch. You can see him taking it all in and really enjoying it. (6/7)

Niall Harbison

123,008 views • 1 year ago

$David Sinclair just revealed one of the biggest studies on nattokinase. A comprehensive Chinese study of 1,067 people found that nattokinase reversed cardiovascular disease by removing up to 95% of arterial plaque in one year. This supplement is an enzyme from fermented soybeans and costs almost nothing. Sinclair has been taking it daily for a couple of years. He measures his carotid artery with ultrasound and says there's no plaque buildup at all. Peter Diamandis takes it too. He believes you need at least 6,000 fibrinolytic units per day to reap the benefits. For context: • Statins cost hundreds per month and come with side effects. • Surgical interventions can cost thousands of dollars Nattokinase costs a fraction of both. Sinclair's caveat: "Do this with the knowledge of your physician." But the data exists. A study of over 1,000 people and up to 95% plaque removal in just 12 months. And the man whose lab is reversing aging takes it every day. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. Grab your ticket in the comments below.$

David Sinclair just revealed one of the biggest studies on nattokinase. A comprehensive Chinese study of 1,067 people found that nattokinase reversed cardiovascular disease by removing up to 95% of arterial plaque in one year. This supplement is an enzyme from fermented soybeans and costs almost nothing. Sinclair has been taking it daily for a couple of years. He measures his carotid artery with ultrasound and says there's no plaque buildup at all. Peter Diamandis takes it too. He believes you need at least 6,000 fibrinolytic units per day to reap the benefits. For context: • Statins cost hundreds per month and come with side effects. • Surgical interventions can cost thousands of dollars Nattokinase costs a fraction of both. Sinclair's caveat: "Do this with the knowledge of your physician." But the data exists. A study of over 1,000 people and up to 95% plaque removal in just 12 months. And the man whose lab is reversing aging takes it every day. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. Grab your ticket in the comments below.

John Cumbers

841,064 views • 4 months ago

Say goodbye to meal prep stress and boring dinners! Forget complicated recipes, today we're showcasing just a few of the surprising ways Addme can turn a simple meal into an extraordinary one. Will you try your hands at any of these mouth watering recipes like margaret_kades? Let us know in the comments! #Addme #Addmie #TheAddmeWay #TheFinalTouchDone

Say goodbye to meal prep stress and boring dinners! Forget complicated recipes, today we're showcasing just a few of the surprising ways Addme can turn a simple meal into an extraordinary one. Will you try your hands at any of these mouth watering recipes like margaret_kades? Let us know in the comments! #Addme #Addmie #TheAddmeWay #TheFinalTouchDone

Addme

122,383 views • 1 year ago

Junior Carson, it's your third year. After two years with high expectations and limited play, day one of camp is crucial. You have to establish dominance and be the headline. No more excuses, just show up and be a menace. #NFL #Football

Junior Carson, it's your third year. After two years with high expectations and limited play, day one of camp is crucial. You have to establish dominance and be the headline. No more excuses, just show up and be a menace. #NFL #Football

Lsbolts15

15,970 views • 6 months ago

Instead of going back and forth with your agent saying "hmm little more, no a little less" just ask it to build you a control to tweak it yourself, then give it the params you like.

Instead of going back and forth with your agent saying "hmm little more, no a little less" just ask it to build you a control to tweak it yourself, then give it the params you like.

Aaron Francis

295,560 views • 3 months ago

When Andrew Huberman asked about the root cause of aging, Dr. David Sinclair gave a surprisingly simple answer: "Aging is a loss of information in the same way you try to copy a cassette tape, or even if you send information across the internet, some of it will get lost." There are two types of information our bodies carry: "There is the genetic information, which is digital — A, T, C, G, the chemical letters of DNA. But there's this other part of the information in the body that's just as important, it's essential, in fact, and that's the systems that control which genes are switched on and off." And when it comes to which one matters more for how long and how well you live, the answer isn't even close: — David Sinclair

When Andrew Huberman asked about the root cause of aging, Dr. David Sinclair gave a surprisingly simple answer: "Aging is a loss of information in the same way you try to copy a cassette tape, or even if you send information across the internet, some of it will get lost." There are two types of information our bodies carry: "There is the genetic information, which is digital — A, T, C, G, the chemical letters of DNA. But there's this other part of the information in the body that's just as important, it's essential, in fact, and that's the systems that control which genes are switched on and off." And when it comes to which one matters more for how long and how well you live, the answer isn't even close: — David Sinclair

John Cumbers

305,874 views • 5 months ago

Tim Dillon: “The government has become 24-hour reality TV.” “It’s a game show called: try to not go insane, we dare you.” “You have less money than you did the year before.” “Your kids have bleaker prospects than they did two years ago.” “You’ll have less money and less job security than you do two years from now.” “You’re not gonna be able to help your kids buy a house.” “You’ve lost healthcare.” “All of this is happening at once, and your job is to try to not go insane.” “All of these news stories just float in and out.” “Assassination attempt one and two, no one understood, they’re done.” “Epstein’s done.” “Hypersonic Dark Eagle missiles going to Iran.” “Demons in the Earth.” “Gas is going up.” “Everything just moves on.” “In a couple of weeks, they’re just gonna go: yeah, there’s aliens.” “There’s no focus. There’s no attention span.” “And you’re supposed to sit there, and you passively watch it.” “Try not to lose your mind, we dare you.” Tim Dillon

Tim Dillon: “The government has become 24-hour reality TV.” “It’s a game show called: try to not go insane, we dare you.” “You have less money than you did the year before.” “Your kids have bleaker prospects than they did two years ago.” “You’ll have less money and less job security than you do two years from now.” “You’re not gonna be able to help your kids buy a house.” “You’ve lost healthcare.” “All of this is happening at once, and your job is to try to not go insane.” “All of these news stories just float in and out.” “Assassination attempt one and two, no one understood, they’re done.” “Epstein’s done.” “Hypersonic Dark Eagle missiles going to Iran.” “Demons in the Earth.” “Gas is going up.” “Everything just moves on.” “In a couple of weeks, they’re just gonna go: yeah, there’s aliens.” “There’s no focus. There’s no attention span.” “And you’re supposed to sit there, and you passively watch it.” “Try not to lose your mind, we dare you.” Tim Dillon

Holden Culotta

113,823 views • 3 months ago