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David Sinclair has spent decades reverse-engineering aging inside his Harvard lab. He proved aging is a disease, not an inevitability. He revealed 10 "normal" habits that are secretly speeding up how fast you age: 1. Eating breakfast every single day

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Dr. David Sinclair said something to Prof Andrew Huberman that left me thinking... "Your cells are forgetting who they are." That is not a metaphor. That is the biological mechanism behind aging itself. Dr. David Sinclair then explained how it works... Every cell in your body carries the same DNA. A nerve cell and a skin cell are genetically identical. What makes them different is which genes are switched on and which are kept silent. That system of switches is called the epigenome. Think of DNA as a music library. The epigenome is the playlist. Each cell plays a specific set of songs. As long as every cell plays the right playlist, the body works perfectly. Aging is what happens when the playlists get corrupted. Genes that should stay silent start activating in the wrong cells. The cell loses its identity. It forgets what it was built to do. And according to Dr. David Sinclair, that single process is the root cause of heart disease, Alzheimer's, and most cancers. Not separate problems. The same problem, showing up in different places. The part that stopped me cold was what comes after that. If aging is information loss, it can be reversed by restoring the information. Dr. David Sinclair's lab has already done this in animals. When they restored the epigenetic signals, the cells remembered what they were. The aging reversed. Huberman asked whether the diseases go away too. Dr. David Sinclair did not hedge. " If you turn the clock back in tissues, those diseases go away." Every generation inherits assumptions about what the body can and cannot do. This one just changed. Follow @YourDocGoku for the science rewriting what we thought was permanent. David Sinclair

Goku

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"we take 92-year old human skin cells back to a biological age of around 25 using OSK." David Sinclair says AI could help make age reversal a reality. 👀 - AI screened up to 1 trillion molecules in just a few months, a task that would have taken hundreds to thousands of years using traditional drug discovery. - AI narrowed 1 trillion molecules to around 200 promising drug candidates for laboratory testing. - Researchers used Google DeepMind's AlphaFold protein predictions to virtually test molecules against human proteins before entering the lab. - AI is also helping determine whether human cells have become biologically younger simply by analyzing images of the cells. - Sinclair says his lab can already reprogram 92-year-old human skin cells to a biological age of around 20-25 using OSK partial cellular reprogramming. - "All my students can do this." - "It's not hard at all to reverse aging in isolated human cells." - "The hard part over the last 10 years has been turning it into a safe and effective drug for people." - Biological age is measured using DNA methylation clocks, which Sinclair says are more informative than relying only on telomeres. - Sinclair believes that one day you may no longer be able to tell how old someone is just by looking at them. - Sinclair says his team has early evidence that lost memories can return after brain rejuvenation, adding that the work has not yet been published. - He believes Alzheimer's patients may still retain their memories but have difficulty accessing them. - He believes making the entire body biologically younger could one day cure diseases that are currently incurable. 🤯 - He also said, making the entire body biologically younger could enable it to heal diseases that are currently incurable. Sinclair's approach is simple: "Make the body young, and it will heal itself."

SciTech Era

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